Chronic myeloid leukemia with e19a2 (c3a2) BCR/ABL fusion junction – is it truly a benign disease?

The e19a2 BCR/ABL fusion transcript with additional chromosomal aberrations on a new case of chronic myeloid leukemia (CML) of mild type

“…Two cases 3,4 had clinical features similar to our patient. The other three 7,8,10 presented a rapid disease progression. Additional chromosomal abnormalities typical of blast crisis characterized two of them 7,8 while the other 10 presented the t(8;21), typical of AML.…”

“…The other three 7,8,10 presented a rapid disease progression. Additional chromosomal abnormalities typical of blast crisis characterized two of them 7,8 while the other 10 presented the t(8;21), typical of AML. Due to the benign clinical course of the disease, a pre-existing silent phase could be advanced in the first two cases, but the rapid evolution in the latter one seems related to a different molecular alteration.…”

“…To date, an e19a2 transcript has been observed in nine patients with CML in the chronic phase, [1][2][3][4][5][6] but also in four with CML rapidly evolving to the blastic phase, [7][8][9][10] and in one with acute myeloid leukemia (AML). 11 Moreover, patients in the chronic phase also presented characteristics of the classical type, such as pronounced leukocytosis and splenomegaly.…”

An accelerrated-phase CML patient with e19a2 junction of BCR/ABL gene - the first case of transplanted CML with micro bcr

“…She is another case of 'classic' CML with micro bcr BCR/ABL gene documenting that patients with this variant of BCR/ABL gene are not only those with a mild course of the disease. The referred patient, with other patients published so far, [2][3][4][5][6][7][8][9] show that the micro bcr CML patients having the e19a2 junction can be in mild, average and high risk stages of the disease. Consequently, the decision about correct treatment of these patients is not easy at present.…”

“…1 The micro bcr gene was originally reported in six cases of CML with a mild course of the disease, which were classified as chronic neutrophilic leukemia (CNL). [2][3][4][5] One case of myeloid blast crisis of CML, 6 another case of putative myeloid blast crisis of CML 7 and two cases of 'classical' CML 8,9 were also reported with this type of the BCR/ABL gene. We report here a CML patient with the micro bcr gene who went into an accelerated phase in which she was transplanted.…”