Chronic myeloid leukemia with isolated central nervous system blast crisis a rare case presentation

Kichloo, Amit; Poddar, Jyoti; Mankada, Sakina; Suryanarayana, U

doi:10.4103/oji.oji_42_19

Cited by 1 publication

(1 citation statement)

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“…Infiltration of the CNS by blast cells is highly uncommon. 14 CNS blast crisis is often associated with meningitis- or encephalitis-related clinical and radiological characteristics, including headache, ataxia, apahasia, seizures, and meningismus, and localized neurological symptoms and signs like. 13 , 21 Myeloid or lymphoid blasts are detected in the cerebrospinal fluid (CSF) and, in certain cases, molecular testing of the CSF reveals typical BCR-ABL oncogenes.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural Hearing Loss in Juvenile CML: A Rare Case Report in Surabaya, Indonesia

Syamsuddin¹,

Notopuro²

2022

IMCRJ

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Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN) in which granulocytes are the primary proliferating cells. CML in pediatric patients (juvenile CML) is an uncommon MPN, representing 2–3% of children newly diagnosed with leukemia. Sensorineural hearing loss that progresses rapidly is an uncommon early sign of a hematological disorder in patients with CML. This article presents the case of a 10-year-old patient with complaints of bilateral hearing loss for 2 weeks. Pure-tone audiometry indicated sensorineural hearing loss of the left ear and mixed hearing loss of the right ear. After an in-depth evaluation of a bone marrow smear and positivity for the BCR-ABL fusion gene, it was concluded that the patient had chronic-phase juvenile CML. However, hearing loss recovery after hydroxyurea therapy could not be observed because the patient died after suffering an uncontrolled seizure on day 14 of hospitalization.

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Section: Discussionmentioning

confidence: 99%