Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum
Rashmi Gamage,
Ilaria Rossetti,
Garry Niedermayer
et al.
Abstract:Background
Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer’s disease (AD). The basal forebrain cholinergic neurons (BFCN) provide the primary source of cholinergic innervation of the human cerebral cortex and may be differentially vulnerable in various neurodegenerative diseases. However, the impact of chronic neuroinflammation on the cholinergic function is … Show more
Ergothioneine (EGT) is a sulfur-containing amino acid with strong antioxidant activity. In this study, a d-galactose induced mice aging model was used to investigate the anti-aging effects of EGT. EGT intervention could significantly improve the...
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