Chronic Neutropenia in Childhood: Laboratory and Clinical Features

Nepesov, Serdar; Yaman, Yöntem; Elli, Murat; Bayram, Nihan; Özdilli, Kürşat; Ayaz, Akif; Anak, Sema

doi:10.1007/s12098-022-04104-4

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Many drugs are recommended for the treatment of SCN, such as G-CSF, corticosteroids, androgens, prophylactic antibiotics or cytotoxic therapies. [ 23 , 24 ] The use of G-CSF is primarily used in patients with myelopoiesis defects and has been shown to be a life-saving intervention in patients with SCN. Treatment of SCN patients with G-CSF improves peripheral neutrophil counts and reduces the risk of infection.…”

Section: Discussionmentioning

confidence: 99%

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Tao,

Yao,

Dong

et al. 2024

Medicine

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Rationale: Severe congenital neutropenia (SCN) is a rare and heterogeneous genetic disease. By describing the diagnosis and treatment of a child with SCN and periodontitis, this case provides a reference for the oral health management of a child with SCN and periodontitis. Patient concerns: We describe a boy with clinical manifestations of oral bleeding, neutropenia, recurrent fever, and other recurrent infections. The absolute neutrophil count (ANC) was <0.50 × 109/L most of the time. Morphological examination of bone marrow cells showed active granulocyte hyperplasia and dysmaturation. Diagnoses: According to the clinical manifestations, hematological examination and gene detection results, the child was diagnosed as SCN with chronic periodontitis. Interventions: Periodontal treatment was performed after informed consent was obtained from the child guardian. These included supragingival and subgingival cleaning, hydrogen peroxide and saline irrigation, placement of iodoglycerin in the gingival sulcus, and oral hygiene instruction. Hematopoietic stem cell transplantation (HSCT) was performed later. Outcomes: One month after initial periodontal treatment, oral hygiene was well maintained and gingival swelling had subsided. Probing depth (PD) index on periodontal probing and bleeding was significantly reduced. However, there was no significant change in blood routine and other indicators before and after periodontal treatment. Conclusion: Once SCN is diagnosed, individualized treatment plans can be developed according to the characteristics of the disease and its impact on oral health, which can effectively control the interaction between SCN and periodontal disease and reduce the occurrence of serious infection.

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Section: Discussionmentioning

confidence: 99%

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Tao,

Yao,

Dong

et al. 2024

Medicine

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“…Autoimmune neutropenia is characterized by chronic neutropenia and the presence of antibodies against human neutrophil antigens. Chronic idiopathic neutropenia and autoimmune neutropenia are rare conditions, also referred to as "primary" or "isolated" because in some diseases, neutropenia is the primary hematological abnormality, both in children and in adults [30].…”

Section: Autoimmune Neutropeniamentioning

confidence: 99%

Neutropenia in Pediatric Oncological Patients

Rosales,

Uribe Rosales,

de Jesús Ramos-Nieto

et al. 2024

New Updates in Tumor Microenvironment [Working Title]

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In 2020, more than 275,000 children and adolescents from 0 to 19 years of age were diagnosed with cancer in the world. Acute myeloid leukemia or acute lymphoblastic leukemia are the most frequent types of cancer. Leukemia is a serious condition that is fatal in many cases. Since tumor cells are present in both, bone marrow and circulating blood, very aggressive therapeutic treatments are required to eliminate tumor cells. Neutrophils are white blood cells that first respond against microbial pathogens and are produced in the bone marrow. Several drugs used in leukemia cancer treatment can reduce the total neutrophil number causing neutropenia. In this chapter we will briefly describe neutrophil maturation and functions as well as the different types of neutropenia. We will also focus on neutropenia consequences and some clinical approaches for treating neutropenia in pediatric patients.

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Chronic Neutropenia in Childhood: Laboratory and Clinical Features

Cited by 2 publications

References 23 publications

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Neutropenia in Pediatric Oncological Patients

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