Chronic non malignant pain and nonsteroid antinflammatory drugs misuse: Nsaid misuse

Abstract

Background and Aims: The aim of this study was to evaluate potential of prognostic cardiac biomarkers by predicting fatal events during perioperative period and the significance of their increased values in all patients and with coronary artery disease (CAD). Methods: The study included 87 patients who underwent major abdominal and vascular surgery. Blood samples were taken from all patients prior to surgery and levels of high-sensitive troponin T (hsTnT) and N-Terminal Pro B-type natriuretic peptide (NT-proBNP) were measured. It was analyzed how their increased values (above the predefined cutoffs of > 14 ng/L and > 300 pg/mL respectively) was associated with perioperative mortality in both all subjects and in patients with CAD.

A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

“…In Serbia, a 17-year-old male presented with moderate low back pain. Haematuria, eosinophilia and decreased creatinine clearance were detected and attributed to NSAID toxicity [ 39 ]. In Australia, a 39-year-old man presented after a 3-day binge of ibuprofen + codeine combination tablets and caffeinated energy drink with profound hypokalaemia attributed to ibuprofen-mediated type 2 renal acidosis combined with the effects of caffeine [ 62 ].…”

“…Current evidence as collated by this review is that nonmedical and extra-medical use of NSAIDs poses significant health risks for individuals. A range of adverse health consequences were described, including nephrotoxicity (acute renal failure and acute interstitial nephritis) [74]; damage to the renal system; asthma exacerbation; gastrointestinal problems [14,49,60,75]; hypertension and other cardiovascular diseases [38]; gastric erosions and ulceration; chronic gastritis; renal necrosis and disease; hepatocyte necrosis [54]; type 1 respiratory failure [5]; oliguria/anuria and gastric bleeds [15]; recurrent hypokalaemia episodes [57,73]; withdrawal symptoms [51]; haematuria, eosinophilia and decreased creatinine clearance [39]. The majority of NSAID overdoses are asymptomatic, which poses a serious risk to people who use NSAIDs excessively without experiencing any noticeable adverse outcomes [35].…”