Chronic obstructive pulmonary disease: an emerging comorbidity in HIV-infected patients in the HAART era?

Madeddu, Giordano; Fois, Alessandro Giuseppe; Calia, Giammario; Babudieri, Sergio; Soddu, Viviana; Becciu, Francesca; Fiori, ML; Spada, Valentina; Lovigu, C; Mannazzu, M.; Caddeo, Antonello; Piras, Bastiana; Pirina, Pietro; Mura, María Stella

doi:10.1007/s15010-012-0330-x

Cited by 88 publications

(76 citation statements)

References 24 publications

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“…28,29 With the introduction of HAART and subsequent immunological recovery of patients, pathology as cronical obstructive pulmonary diseases (COPD), a widely spread disease in the general population, caused most significantly by smoking, 30 will increase and will probably become a new and significant comorbidity for HIV patients, especially where there is airway colonization by PCP. 31 Hence, it would be advisable to conduct early diagnosis screening of COPD in HIV patients with predisposing risk factors, 32 aimed at taking preventive measures. In a future healthcare providers should be aware of the increased likelihood of airway obstruction among HIV patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

Perelló

Escoda

Camón

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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a b s t r a c tAim: To describe the, incidence, the changes in the etiology and the prognosis of lower respiratory tract infection (LRTI) in HIV infected patients, presenting by the first time to the Emergency Department (ED), during years 2000-2010. Study design: Prospective collection of data. Metbods: Data were collected on the first visit of HIV-infected patients at our ED due to a LRTI, (defined according to the criteria of the European Respiratory Society), between 1/1/2000 and 31/12/2010. A series of epidemiological and laboratory variables as well as the need for admission to the intensive care unit (ICU). LRTI etiology were also collected. The influence ofthe mentioned variables on 30-day mortality were analyzed. Results: One hundred thirty one patients were included. LRTI represented 27% of visits to the ED by HIV-infected patients. Mean age was 39±9 years. 72% of patients were males. 18% required admission to the ICU. The most frequent LRTI was pneumonia by P. jiroveci in 35 cases, bacterial penumonia in 27 and pulmonary tuberculosis in 20. LRTI incidence gradually reduced significantly over time from 6.13 × 1000 patients/year in year 2000 to 0.23 × 1000 patients/year in 2010 (p<0.05). Overall mortality was 14%. Logistic regression analysis showed that admission to ICU (p<0.004) and viral load (p<0.029) were independent variables predicting mortality. Conclusion: LRTI is a pathology with a decreasing incidence, probably related to the widespread utilization increased of HAART regimens. lts etiology has also been changing, but with a non negligible mortality, mostly when ICU admission was required.© 2014 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.Cambios en la etiología, incidencia y pronóstico de la infección respiratoria aguda de vías bajas en pacientes infectados por el virus de la inmunodeficiencia humana Infecc Microbiol Clin. 2014;xxx(xx):xxx-xxx así como la necesidad de ingreso en una unidad de cuidados intensivos (UCI). Se estudió la etiología de la IRVB y la incidencia. Finalmente se analizaron la influencia de las variables con la mortalidad a 30 días. Resultados: Se incluyeron un total de 131 pacientes. La edad media fue de 39 ± 9 años. El 72% de los pacientes eran varones y el 18% de los pacientes requirieron ingreso en la UCI. La IRVB más frecuente fue la neumonía por P. jirovecci, seguida de la neumonía bacteriana en 27 y la tuberculosis pulmonar en 20. La incidencia de IRVB se ha ido reduciendo gradualmente de forma significativa, 6,13 × 1.000 pacientes/año en 2000 a 0,23 × 1.000 pacientes/año en 2010 (p < 0,05). El análisis de regresión logística mostró que la única variable que predijo mortalidad fue el ingreso en UCI (p < 0,05; OR: 73,01). Conclusión: La IRVB es una enfermedad cuya incidencia y etiología han ido disminuyendo y cambiando respectivamente, probablemente en relación con la utilización generalizada del TAR. Sin embargo, todavía presenta una mortalidad nada despreciable, que es mayor cuando el paci...

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Section: Discussionmentioning

confidence: 99%

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

Perelló

Escoda

Camón

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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“…26 An interesting recent study has shown that the prevalence of smoking may be up to three times higher in HIV-positive patients than in the general population, 27 which is an alarming finding, particularly given the high risk for morbidity in this category of patients. The risk of chronic obstructive pulmonary disease 28 and that of local infections due to a baseline suppressive lung inflammatory environment 29 have been clearly described, but the cardiac involvement is still to be determined.…”

Section: Discussionmentioning

confidence: 99%

Cardiac involvement in HIV-positive patients

Daglan

Yamin

Manu

et al. 2013

GERMS

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“…11,12 COPD is an independent risk factor for high mortality in people living with HIV, and current cigarette smoking plays a significant role in its development irrespective of HAART use. 11 Therefore, smoking cessation is crucial to reduce the high mortality rate of the population. Nevertheless, people living with HIV smoke cigarettes substantially at higher rates than the general population, that is, 40%-80% vs. 19%.…”

Section: Kim Et Almentioning

confidence: 99%

A pilot study of a smoking cessation intervention for women living with HIV: study protocol

Kim¹,

Darwish²,

Lee³

et al. 2017

OAJCT

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Chronic obstructive pulmonary disease: an emerging comorbidity in HIV-infected patients in the HAART era?

Cited by 88 publications

References 24 publications

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

Cardiac involvement in HIV-positive patients

A pilot study of a smoking cessation intervention for women living with HIV: study protocol

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