Chronic obstructive pulmonary disease caused by inhalation of dust

Peng, Cong; Yan, Yulin; Li, Zhen; Jiang, Yuxin; Cai, Yu-Dong

doi:10.1097/md.0000000000021908

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Inhalation is a major route of airborne toxicant exposure, in which the lung epithelial barrier serves as the main portal of entry into the systemic circuit for the human body. This may lead to progressive and perpetual inflammation of the epithelium leading to development of chronic respiratory conditions such as asthma, COPD, ARDS and interstitial lung diseases (ILD) ( Baumgartner et al, 2000 ; Sokol et al, 2013 ; Assad et al, 2018 ; Zhao et al, 2019 ; Peng et al, 2020 ; Shima et al, 2022 ). Inhaled toxicants are ubiquitous across the globe and come from a variety of sources ranging from organic pollution to industrial chemicals and consumer-related products ( Adeola, 2021 ; Naidu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

et al. 2023

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Prolonged exposure to environmental respirable toxicants can lead to the development and worsening of severe respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD) and fibrosis. The limited number of FDA-approved inhaled drugs for these serious lung conditions has led to a shift from in vivo towards the use of alternative in vitro human-relevant models to better predict the toxicity of inhaled particles in preclinical research. While there are several inhalation exposure models for the upper airways, the fragile and dynamic nature of the alveolar microenvironment has limited the development of reproducible exposure models for the distal lung. Here, we present a mechanistic approach using a new generation of exposure systems, the Cloud α AX12. This novel in vitro inhalation tool consists of a cloud-based exposure chamber (VITROCELL) that integrates the breathing AXLung-on-chip system (AlveoliX). The ultrathin and porous membrane of the AX12 plate was used to create a complex multicellular model that enables key physiological culture conditions: the air-liquid interface (ALI) and the three-dimensional cyclic stretch (CS). Human-relevant cellular models were established for a) the distal alveolar-capillary interface using primary cell-derived immortalized alveolar epithelial cells (AXiAECs), macrophages (THP-1) and endothelial (HLMVEC) cells, and b) the upper-airways using Calu3 cells. Primary human alveolar epithelial cells (AXhAEpCs) were used to validate the toxicity results obtained from the immortalized cell lines. To mimic in vivo relevant aerosol exposures with the Cloud α AX12, three different models were established using: a) titanium dioxide (TiO2) and zinc oxide nanoparticles b) polyhexamethylene guanidine a toxic chemical and c) an anti-inflammatory inhaled corticosteroid, fluticasone propionate (FL). Our results suggest an important synergistic effect on the air-blood barrier sensitivity, cytotoxicity and inflammation, when air-liquid interface and cyclic stretch culture conditions are combined. To the best of our knowledge, this is the first time that an in vitro inhalation exposure system for the distal lung has been described with a breathing lung-on-chip technology. The Cloud α AX12 model thus represents a state-of-the-art pre-clinical tool to study inhalation toxicity risks, drug safety and efficacy.

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Section: Introductionmentioning

confidence: 99%

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

et al. 2023

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“…11 reviews identified occupational exposures associated with an increased risk of COPD [ 44 , 56 – 58 , 66 , 67 , 71 , 79 , 84 , 88 , 93 ]. Eight of those studies found that workers exposed to dust as compared to nonexposed had an increased risk of COPD [ 56 – 58 , 66 , 71 , 79 , 84 , 93 ], with found mORs ranging from 0.97 (95% CI 0.68–1.39) by B ellou et al . [ 79 ] to 1.79 (95% CI 1.15–2.79), found by Y ang et al .…”

Section: Resultsmentioning

confidence: 99%

“…This shows how efforts of prevention could take advantage of this protective effect by including lifestyle measures, beyond smoking cessation, and include nutritional counselling. Eight reviews [ 56 – 58 , 66 , 71 , 79 , 84 , 93 ] identified occupational dust as a risk factor, indicating efforts should be made to reduce dust exposure in the workplace and/or provide workers with protective equipment to mitigate the risk. Lastly, four reviews identified parental COPD as a risk factor independent of having specific genetic variations [ 57 , 65 , 72 , 85 ], possibly making it easier to identify people at risk early on.…”

Section: Discussionmentioning

confidence: 99%

Identifying risk factors for COPD and adult-onset asthma: an umbrella review

et al. 2023

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BackgroundCOPD and adult-onset asthma (AOA) are the most common noncommunicable respiratory diseases. To improve early identification and prevention, an overview of risk factors is needed. We therefore aimed to systematically summarise the nongenetic (exposome) risk factors for AOA and COPD. Additionally, we aimed to compare the risk factors for COPD and AOA.MethodsIn this umbrella review, we searched PubMed for articles from inception until 1 February 2023 and screened the references of relevant articles. We included systematic reviews and meta-analyses of observational epidemiological studies in humans that assessed a minimum of one lifestyle or environmental risk factor for AOA or COPD.ResultsIn total, 75 reviews were included, of which 45 focused on risk factors for COPD, 28 on AOA and two examined both. For asthma, 43 different risk factors were identified while 45 were identified for COPD. For AOA, smoking, a high body mass index (BMI), wood dust exposure and residential chemical exposures, such as formaldehyde exposure or exposure to volatile organic compounds, were amongst the risk factors found. For COPD, smoking, ambient air pollution including nitrogen dioxide, a low BMI, indoor biomass burning, childhood asthma, occupational dust exposure and diet were amongst the risk factors found.ConclusionsMany different factors for COPD and asthma have been found, highlighting the differences and similarities. The results of this systematic review can be used to target and identify people at high risk for COPD or AOA.

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“…It is a significant hazardous occupational hazard that pollutes the workplace environment and affects workers' health, contributing to the creation of different occupational lung diseases. Studies stated that occupational dust exposure may be causally associated with the pathogenesis of COPD [23]. Different literature on coal miners' airflow obstruction concluded that there was an obvious link between exposure to coal dust and the creation of chronic obstruction of airflow.…”

Section: Occupational Dust Exposure and Copdmentioning

confidence: 99%

“…Occupational exposures to dust, fumes, and gases are associated with increased prevalence of respiratory symptoms and impairment of lung function. Any part of the respiratory tract can be adversely affected by poor air quality from the nose to the alveoli [23,28] mechanisms, the inherent toxicity of particles, pattern of deposition, removal from the respiratory tract and the properties of the air contaminants (WHO, 2005).…”

Section: Effects Of Dust On the Respiratory Functionmentioning

confidence: 99%

Work - Related Chronic Obstructive Pulmonary Disease

Getahun¹,

Bekel²

2021

Chronic Obstructive Pulmonary Disease - A Current Conspectus

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Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by airflow obstruction and increasing breathlessness. COPD is increasing worldwide, both in developed and developing countries. The most important risk factor of developing COPD is cigarette smoking; however, occupational exposures such as vapors, gases, dusts and fumes present an important risk factor for the development of the disease, by itself and through interaction with other risk factors. The dusts from coal, stone quarries, wood, cereals and agricultural work, animal stables, textiles, and paper production that can arise in occupational environments have been regulated by the International Labor Organization and considered possible as contributors to COPD. A better understanding of these causes paves the way for effective interventions to reduce the future incidence of this unpleasant condition. Breathlessness and occupational exposures to vapors, gases, dusts and fumes were identified as the main modifiable factors associated with unemployment and poor work productivity in COPD patients.

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Chronic obstructive pulmonary disease caused by inhalation of dust

Cited by 16 publications

References 27 publications

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip

Identifying risk factors for COPD and adult-onset asthma: an umbrella review

Work - Related Chronic Obstructive Pulmonary Disease

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