Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD

Guiedem, Elise; Ikomey, George Mondinde; Nkenfou, Céline Nguefeu; Walter, Pefura-Yone Eric; Mesembe, Martha; Chegou, Novel N.; Jacobs, Graeme Brendon; Assoumou, Marie Claire Okomo

doi:10.1186/s13104-018-3309-6

Cited by 26 publications

(15 citation statements)

References 19 publications

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“…Studies report that myeloperoxidase and elastase released by activated neutrophils amplify the production of IL-8 [ 29 ], which would justify its high concentration in COPD/tobacco patients who have a higher number of neutrophils. Our recent study on the same population showed that the neutrophil count was higher in post-smoking COPD compared to the post-TB form [ 30 ]. GRO is an important chemotactic mediator of neutrophils, endothelial cell adhesion and degranulation.…”

Section: Discussionmentioning

confidence: 99%

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

et al. 2020

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Background Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction and tobacco-related COPD have the same functional pathway characterized by persistent airflow limitation. We sought to compare the profile of 29 cytokines in the sputum of subjects with post-TB airflow obstruction and those with COPD related to tobacco. Results The forced expiratory volume in the first second (FEV1) and forced expiratory volume/forced vital capacity (FEV/FVC) ratio were lower in the COPD patients with the history of smoking compared to the post-TB airflow obstruction subgroup. The stages of the disease were more advanced in COPD / tobacco patients. Among the cytokines, IL-1α, IL-1β, MIP-1β, sCD40L and VEGF levels were higher in COPD patients, compared to the controls with p values of 0.003, 0.0001, 0.03, 0.0001 and 0.02 respectively. When the two COPD subgroups were compared, IL-1α, IL-6, TNF-α and IL-8 levels were higher in the COPD patients with the history of tobacco compared to the COPD patients with the history of TB with p-values of 0.031, 0.05, 0.021 and 0.016, respectively. Conclusion COPD related to tobacco is more severe than post-TB airflow obstruction. The pathogenesis of post-TB airflow obstruction appears to involve the cytokines IL-1RA, IL-1α, IL-1β, IL-17, GRO and sCD40L, while COPD related to tobacco involves more cytokines.

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Section: Discussionmentioning

confidence: 99%

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

et al. 2020

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“…Neutrophils are also commonly found in airways of individuals with severe asthma [42] and cystic fibrosis [43]. A greater number of neutrophils in the lavage fluid of smokers, as well as the sputum of people with COPD, has also been reported [44, 45]. Neutrophils modify mucus properties and increase mucus viscosity through releasing DNA nets [46, 47].…”

Section: Gel-forming Mucinsmentioning

confidence: 99%

Strategies for measuring airway mucus and mucins

Atanasova

Reznikov

2019

Respir Res

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Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD). Studying mucus composition and its physical properties has therefore been of significant interest both clinically and scientifically. Yet, measuring mucus production, output, composition and transport presents several challenges. Here we summarize and discuss the advantages and limitations of several techniques from five broadly characterized strategies used to measure mucus secretion, composition and mucociliary transport, with an emphasis on the gel-forming mucins. Further, we summarize advances in the field, as well as suggest potential areas of improvement moving forward.

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“…In addition, studies report that myeloperoxidase and elastase released by activated neutrophils amplify the production of IL-8, which would justify its high concentration in COPD/tobacco patients who have a higher number of neutrophils. Our recent study on the same population showed that the neutrophil count was higher in post-smoking COPD compared to the post-TB form [31]. GRO is an important chemotactic mediator of neutrophils, endothelial cell adhesion and degranulation.…”

Section: Discussionmentioning

confidence: 87%

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

Guiedem

Pefura-Yone

Ikomey

et al. 2020

Preprint

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Background: Previous studies have shown that tuberculosis (TB) is a risk factor for chronic airflow limitation. Chronic obstructive pulmonary disease (COPD) is recognized as the result of chronic inflammation, usually related to noxious particles. Post-TB airflow obstruction (post-TB/AFO) and tobacco-related COPD (COPD/tobacco) have the same functional pathway characterized by persistent airflow limitation. We sought to compare the profile of 29 cytokines in the sputum of subjects with post-TB/AFO and those with COPD/tobacco. Results: The forced expiratory volume in the first second (FEV 1 ) and FEV1/forced vital capacity (FEV 1 /FVC) ratio were lower in the COPD/tobacco subgroup compared to the COPD/post-TB subgroup. The stages of the disease were more advanced in COPD / tobacco patients. Among the cytokines, IL-1α, IL-1β, MIP-1β, sCD40L and VEGF levels were higher in COPD patients, compared to the controls with p values of 0.003, 0.0001, 0.03, 0.0001 and 0.02 respectively. When the two COPD subgroups were compared, IL-1α, IL-6, TNF-α and IL-8 levels were higher in the COPD/tobacco subgroup compared to the COPD/post-TB subgroup with p-values of 0.031, 0.05, 0.021 and 0.016 respectively. Conclusion: COPD/tobacco is more severe than post-TB/AFO. The pathogenesis of post-TB/AFO appears to involve the cytokines IL-1RA, IL-1α, IL-1β, IL-17, GRO and sCD40L, while COPD/tobacco involves more cytokines.

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Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD

Cited by 26 publications

References 19 publications

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

Strategies for measuring airway mucus and mucins

Cytokine profile in the sputum of subjects with post-tuberculosis airflow obstruction and in those with tobacco related chronic obstructive pulmonary disease

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