Chronic occupational exposures to irritants and asthma in the CONSTANCES cohort

Sit, Guillaume; Orsi, Laurent; Iwatsubo, Yuriko; Dananché, Brigitte; Orsi, Florence; Goldberg, Marcel; Leynaert, Benedicte; Nadif, Rachel; Ribet, Céline; Roche, Nicolas; Roquelaure, Yves; Varraso, Raphäelle; Zins, Marie; Pilorget, Corinne; Le Moual, Nicole; Dumas, Orianne

doi:10.1136/oemed-2023-109100

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Exposure to certain substances in the workplace, such as irritants ( 47 ), chemicals, dust and fumes, can trigger asthma symptoms in adult life ( 48 ). The CONSTANCES cohort has shown that exposure to solvents and to irritants can trigger adult asthma ( 49 , 50 ).…”

Section: Other Risk Factors For Late Onset T2 Eosinophilic Asthmamentioning

confidence: 99%

Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

Scadding,

Gray,

Conti

et al. 2024

Front. Allergy

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The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in addition to the need to improve population health via multiple measures, including reduction of exposure to allergens and pollutants and avoidance of obesity, there are several possible specific means to reduce asthma development in those most at risk (pre- asthma). The most obvious is allergen immunotherapy (AIT), which when given for allergic rhinitis (AR) has reasonable evidence to support asthma prevention in children (2) but also needs further study as primary prevention. In this second paper we explore the possibilities for similar actions in late onset eosinophilic asthma.

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Section: Other Risk Factors For Late Onset T2 Eosinophilic Asthmamentioning

confidence: 99%

Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

Scadding,

Gray,

Conti

et al. 2024

Front. Allergy

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Development of a crosswalk to convert French PCS2003 into international ISCO88 occupational classifications. Application to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM)

Pilorget,

Dananché,

Garras

et al. 2024

Annals of Work Exposures and Health

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Introduction The problem of transcoding is recurrent when researchers wish to link occupational data from cohorts to Job-Exposure Matrices (JEMs) which were not set up in the same classifications. The Occupational Asthma-specific JEM (OAsJEM) is a JEM developed for assessing exposure to agents known at risk for asthma for jobs coded with ISCO88 occupation classification. To apply the OAsJEM in the CONSTANCES cohort, in which jobs and industries were coded with French PCS2003 and NAF2008 classifications respectively, we developed a crosswalk to convert jobs from PCS2003 into ISCO88 classification. Methods This work was carried out by 2 skilled coders and 1 novice coder who have worked independently by using different tools and transcoding strategies defined a priori. Consensus meetings were organized with skilled coders to define the final crosswalk. This work was elaborated in 2 steps: (i) for 38 ISCO88 codes classified as potentially exposed to cleaning and disinfection products by the OAsJEM, and (ii) for all jobs from the ISCO88 classification. A comparison between the 3 initial coder’s crosswalk proposals and the final crosswalk was made for the 38 ISCO codes in step (i). Results The final crosswalk provided 998 matches between the 482 4-digit PCS2003 codes, 308 4-digit ISCO88 codes, and 31 3-digit ISCO88 codes. Information regarding the NAF2008 industry classification was also used in some cases to improve the final crosswalk. For the selected 38 ISCO88 codes, the final crosswalk provided 110 combinations, but the number of proposed ISCO88–PCS2003 couples by each of the 3 coders varied greatly from 68 to 153. In addition, an important variability between the 3 coders were observed among the number of common combinations between the initial coder’s proposals and the final crosswalk (from 47% to 78%). Discussion We have developed a crosswalk specifically for an application of the OAsJEM in population-based surveys using the PCS2003 occupation classification. The development of this crosswalk is of great interest for the use of OAsJEM on the data of the CONSTANCES cohort and on any other survey with occupational data coded according to the French classifications. This OAsJEM crosswalk could be used by other teams to evaluate occupational exposures known to be at risk of asthma from occupational calendars coded with French classifications.

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Chronic occupational exposures to irritants and asthma in the CONSTANCES cohort

Cited by 2 publications

References 39 publications

Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma

Development of a crosswalk to convert French PCS2003 into international ISCO88 occupational classifications. Application to the Occupational Asthma-specific Job-Exposure Matrix (OAsJEM)

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