Chronic pain after colon cancer surgery: Translation and validation of a scoring system

Alharbi, Reem; Elfeki, Hossam; Emmertsen, Katrine Jøssing; Mortensen, A. R.; Drewes, Asbjørn Mohr; Christensen, Peter; Laurberg, Søren; Juul, Therese

doi:10.1111/codi.16339

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Disease-and treatment-related toxicity, such as pain, is common in patients with COAD and may lead to a reduction in their overall quality of life [19,20] . The incidence of chronic pain after surgical cancer treatment varies signi cantly with the type of cancer, treatment method, age, inherited variability, and psychiatric factors [21] .…”

Section: Introductionmentioning

confidence: 99%

Acquisition and validation of four painful subtypes of colon adenocarcinoma and prognostic analysis

Yao,

Lv,

et al. 2024

Preprint

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Background: Colon adenocarcinoma (COAD) is the most common type of colorectal cancer. Pain is a multidimensional unpleasant experience and various molecular and cellular pathways are implicated in pain signaling. Nevertheless, the exploration of pain-related genes related to colon adenocarcinoma is not clear yet. Methods: In this study, the pathways enriched for pain-related genes were analyzed by Metascape. Then, we obtained pain subtypes versus classical subtypes and explored the link between the two. Next, marker genes for different pain subtypes were identified, the enrichment pathways were explored and these marker genes were used to validate the pain subtypes. We then performed an investigation of survival differences between pain subtypes by selecting specific top pathways in each subtype, calculating top pathway scores, and calculating pathway differences by heatmap and Kruskal test. Finally, we predicted the response of different pain subtypes to immunotherapy. Results: A total of 146 pain-related genes were enrolled in this study and we finally obtained 4 painful subtypes and 4 stable subtypes. The marker genes for subtypes were validated by The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets and found to have a worse prognosis for CS1. The genes of CS1, CS2, CS3 and CS4 markers were mainly enriched in the pathways of Focal adhesion, Human T cell leukemia virus1 infection, Metabolic pathway, and Pertussis, respectively. CS1 and CS4 are more immunogenic. Moreover, CS1 is more sensitive to treatment with CTLA4 inhibitors, CS4 is sensitive to treatment with PD-1 inhibitors. Conclusions: Our study's identification of four pain subtypes of COAD provides new ideas for personalised therapy for patients with COAD.

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Section: Introductionmentioning

confidence: 99%

Acquisition and validation of four painful subtypes of colon adenocarcinoma and prognostic analysis

Yao,

Lv,

et al. 2024

Preprint

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“…It is currently unclear how chronic pain after colon cancer surgery develops. In particular, the lack of a validated technique for measuring chronic pain is a serious problem because it is essential for determining the incidence and risk factors [13]. The International Association for the Study of Pain (IASP) created a systematized taxonomy of chronic pain syndromes that distinguishes between chronic primary and chronic secondary pain syndromes.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Palliative Care on Mitigating Pain and Its Associated Effects in Determining Quality of Life among Colon Cancer Outpatients

Macharia,

Raposa,

Sipos

et al. 2023

Healthcare

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Pain continues to be a significant problem for cancer patients, and the impact of a population-based strategy on their experiences is not completely understood. Our study aimed to determine the impact of palliative care on mitigating pain and its associated effects in determining the quality of life (QoL) among colon cancer outpatients. Six collection databases were used to perform a structured systematic review of the available literature, considering all papers published between the year 2000 and February 2023. PRISMA guidelines were adopted in our study, and a total of 9792 papers were evaluated. However, only 126 articles met the inclusion criteria. A precise diagnosis of disruptive colorectal cancer (CRC) pain disorders among patients under palliative care is necessary to mitigate it and its associated effects, enhance health, promote life expectancy, increase therapeutic responsiveness, and decrease comorbidity complications. Physical activities, the use of validated pain assessment tools, remote outpatient education and monitoring, chemotherapeutic pain reduction strategies, music and massage therapies, and bridging social isolation gaps are essential in enhancing QoL. We recommend and place a strong emphasis on the adoption of online training/or coaching programs and the integration of formal and informal palliative care systems for maximum QoL benefits among CRC outpatients.

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Acquisition and validation of four pain subtypes of colon adenocarcinoma and prognostic analysis

Yao,

Lv,

et al. 2024

Journal of Anesthesia and Translational Medicine

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Chronic pain after colon cancer surgery: Translation and validation of a scoring system

Cited by 4 publications

References 19 publications

Acquisition and validation of four painful subtypes of colon adenocarcinoma and prognostic analysis

Acquisition and validation of four painful subtypes of colon adenocarcinoma and prognostic analysis

The Impact of Palliative Care on Mitigating Pain and Its Associated Effects in Determining Quality of Life among Colon Cancer Outpatients

Acquisition and validation of four pain subtypes of colon adenocarcinoma and prognostic analysis

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