Chronic Pain After Lung Transplantation and Its Impact on Quality of Life: A 4-Year Follow-up

Loxe, Samanta Coelho; Mello, Liliane Saraiva de; Câmara, Lígia; Teixeira, Ricardo Henrique de Oliveira Braga; Salveti, Marina de Góes; Galas, Filomena Barbosa Gomes; Júnior, José Otávio Costa Auler; Castro, Caio César Bianchi de; Pereira, Mara Helena Corso; Jardim, Jaquelline Maria

doi:10.1016/j.transproceed.2020.02.032

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…to be less painful compared with a regular thoracotomy because it is less invasive, however, incidence and severity of CPSP have been reported to be similar. 8 CPSP after thoracic surgery has been associated with a lower overall quality of life, [9][10][11][12][13] and chronic pain is associated with an increased utilisation of healthcare, increased absenteeism and decreased work-related effectiveness. [14][15][16] The direct health-related costs of chronic pain have been reported to be US$11 846 annually, 17 and the indirect work-related costs have been reported to be US$29 617 annually.…”

Section: Open Accessmentioning

confidence: 99%

Prognostic factors for chronic post-surgical pain after lung or pleural surgery: a protocol for a systematic review and meta-analysis

et al. 2021

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IntroductionChronic post-surgical pain (CPSP) after lung or pleural surgery is a common complication and associated with a decrease in quality of life, long-term use of pain medication and substantial economic costs. An abundant number of primary prognostic factor studies are published each year, but findings are often inconsistent, methods heterogeneous and the methodological quality questionable. Systematic reviews and meta-analyses are therefore needed to summarise the evidence.Methods and analysisThe reporting of this protocol adheres to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. We will include retrospective and prospective studies with a follow-up of at least 3 months reporting patient-related factors and surgery-related factors for any adult population. Randomised controlled trials will be included if they report on prognostic factors for CPSP after lung or pleural surgery. We will exclude case series, case reports, literature reviews, studies that do not report results for lung or pleural surgery separately and studies that modified the treatment or prognostic factor based on pain during the observation period. MEDLINE, Scopus, Web of Science, Embase, Cochrane, CINAHL, Google Scholar and relevant literature reviews will be searched. Independent pairs of two reviewers will assess studies in two stages based on the PICOTS criteria. We will use the Quality in Prognostic Studies tool for the quality assessment and the CHARMS-PF checklist for the data extraction of the included studies. The analyses will all be conducted separately for each identified prognostic factor. We will analyse adjusted and unadjusted estimated measures separately. When possible, evidence will be summarised with a meta-analysis and otherwise narratively. We will quantify heterogeneity by calculating the Q and I2 statistics. The heterogeneity will be further explored with meta-regression and subgroup analyses based on clinical knowledge. The quality of the evidence obtained will be evaluated according to the Grades of Recommendation Assessment, Development and Evaluation guideline 28.Ethics and disseminationEthical approval will not be necessary, as all data are already in the public domain. Results will be published in a peer-reviewed scientific journal.PROSPERO registration numberCRD42021227888.

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Section: Open Accessmentioning

confidence: 99%

Prognostic factors for chronic post-surgical pain after lung or pleural surgery: a protocol for a systematic review and meta-analysis

et al. 2021

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“…Due to the variability between patient presenting ESLD and diverse associated morbidities, postoperative pain management in the lung transplant population is challenging [33,34]. Poor analgesic control in these patients not only leads to perioperative morbidities, but can lead to long-term chronic pain resulting in decreased quality of life [35]. Therefore, it is imperative that a lung transplant anesthesiology program design a postoperative analgesic service that is based on the latest principles of multimodal analgesia to contribute optimal care to patients during recovery.…”

Section: Postoperative Role Of Anesthesiologists In Establishing An Analgesia Servicementioning

confidence: 99%

Practical considerations for developing a lung transplantation anesthesiology program

Fritz

Martin

Ramakrishna

2021

Indian J Thorac Cardiovasc Surg

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The advancement in lung transplantation outcomes has been secondary to ongoing improvements within multiple medical specialties. The recent emergence of literature describing the impact of anesthetic management on perioperative outcomes has led to the beginnings of formalized training fellowships within lung transplantation anesthesiology. Practical considerations for the development of a lung transplantation anesthesiology program, both clinical and educational, are herein described.

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“…The reported prevalence of PTPS after LTx is inconsistent; the various types of incisions and pain assessment tools among teams might account for this 13–15 . Overall, nearly half of patients experience PTPS 16–18 . In a recent prospective cohort study of 72 double LTx recipients, Laurent et al reported a high prevalence of chronic pain (68%).…”

Section: Introductionmentioning

confidence: 99%

“…[13][14][15] Overall, nearly half of patients experience PTPS. [16][17][18] In a recent prospective cohort study of 72 double LTx recipients, Laurent et al reported a high prevalence of chronic pain (68%). Indeed, it was primarily associated with mild pain intensity (83.3%) but has significantly affected patients' quality of life and mental well being.…”

Section: Introductionmentioning

confidence: 99%

Regional analgesia for lung transplantation

Azem

Mangoubi

Zribi

et al. 2023

European Journal of Anaesthesiology

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Lung transplantation (LTx) is the definitive treatment for end-stage pulmonary disease. About 4500 LTxs are performed annually worldwide.It is considered challenging and complex surgery regarding anaesthesia and pain management. While providing adequate analgesia is crucial for patient comfort, early mobilisation and prevention of postoperative pulmonary complications, standardising an analgesic protocol is challenging due to the diversity of aetiologies, surgical approaches and the potential use of extracorporeal life support (ECLS).Although thoracic epidural analgesia is commonly considered the gold standard, concerns regarding procedural safety and its potential for devastating consequences have led physicians to seek safer analgesic modalities such as thoracic nerve blocks.The advantages of thoracic nerve blocks for general thoracic surgery are well established. However, their utility in LTx remains unclear.Considering paucity of relevant literature, this review aims to raise awareness about the literature gap in the field and highlight the need for further high-quality studies determining the effectiveness of available techniques.

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Chronic Pain After Lung Transplantation and Its Impact on Quality of Life: A 4-Year Follow-up

Cited by 11 publications

References 19 publications

Prognostic factors for chronic post-surgical pain after lung or pleural surgery: a protocol for a systematic review and meta-analysis

Prognostic factors for chronic post-surgical pain after lung or pleural surgery: a protocol for a systematic review and meta-analysis

Practical considerations for developing a lung transplantation anesthesiology program

Regional analgesia for lung transplantation

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