Chronic pain alters spatiotemporal activation patterns of forearm muscle synergies during the development of grip force

Manickaraj, Nagarajan; Bisset, Leanne; Devanaboyina, Venkata S. P. T.; Kavanagh, Justin J.

doi:10.1152/jn.00210.2017

Cited by 14 publications

(30 citation statements)

References 47 publications

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“…Three studies used a clinical case-control, cross-sectional design [ 25 , 58 , 59 ], three studies used a repeated measures experimental pain design [ 24 , 43 , 60 ], and one study used a clinical case-control, with repeated measures design [ 61 ] ( Table 1 ). One study performed synergy analysis before and after treatment (surgery) in a clinical population, which explains the repeated measures design [ 61 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…One study performed synergy analysis before and after treatment (surgery) in a clinical population, which explains the repeated measures design [ 61 ] ( Table 1 ). Three studies investigated muscle synergies on the upper limb [ 25 , 58 , 60 ], one on the lower limb [ 59 ], two on the spinal region [ 24 , 61 ], and one on a combined spine-lower limb region [ 43 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

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The influence of musculoskeletal pain disorders on muscle synergies—A systematic review

2018

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BackgroundMusculoskeletal (MSK) pain disorders represent a group of highly prevalent and often disabling conditions. Investigating the structure of motor variability in response to pain may reveal novel motor impairment mechanisms that may lead to enhanced management of motor dysfunction associated with MSK pain disorders. This review aims to systematically synthesize the evidence on the influence of MSK pain disorders on muscle synergies.MethodsNine electronic databases were searched using Medical Subject Headings and keywords describing pain, electromyography and synergies. Relevant characteristics of included studies were extracted and assessed for generalizability and risk of bias. Due to the significant heterogeneity, a qualitative synthesis of the results was performed.ResultsThe search resulted in a total of 1312 hits, of which seven articles were deemed eligible. There was unclear consistency that pain reduced the number of muscle synergies. There were low consistencies of evidence that the synergy vector (W weights) and activation coefficient (C weights) differed in painful compared to asymptomatic conditions. There was a high consistency that muscle synergies were dissimilar between painful and asymptomatic conditions.ConclusionsMSK pain alters the structure of variability in muscle control, although its specific nature remains unclear. Greater consistency in muscle synergy analysis may be achieved with appropriate selection of muscles assessed and ensuring consistent achievement of motor task outcomes. Synergy analysis is a promising method to reveal novel understandings of altered motor control, which may facilitate the assessment and treatment of MSK pain disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The influence of musculoskeletal pain disorders on muscle synergies—A systematic review

2018

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“…Weiss and Flanders demonstrated approximately 3-4 synergies were needed to account for > 90% of the variance of EMG recorded from ve intrinsic and two extrinsic nger muscles during grasping or spelling tasks [43]. Manickaraj et al, identi ed 2-3 synergies from ve forearm muscles to account for > 90% of the variance during wrist movement tasks [51]. Zariffa et al, showed 5 synergies can be extracted from eight electrodes (> 85% variance explained) across inhand and forearm muscles during functional grasping tasks [42].…”

Section: Dimensionality Of Hand/wrist Muscle Contraction In Able-bodimentioning

confidence: 99%

“…The structure and activation of muscle synergies of upper limbs can be altered by impaired sensorimotor neural pathways, such as those found in stroke [36], spinal cord injury [42], dystonia [54], and pain [51].…”

Section: Dimensionality Of Hand/wrist Muscle Contraction In Transradimentioning

confidence: 99%

Dimensionality of forearm muscle activation in transradial amputees

McClanahan¹,

Moench²,

Fu³

2020

Preprint

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Background Establishing a natural communication interface between the user and the terminal device is one of the central challenges of hand neuroprosthetics research. Surface electromyography (EMG) is the most common source of neural signals for interpreting a user’s intent in these interfaces. However, how the capacity of EMG generation is affected by various clinical parameters remains largely unknown. Methods In this retrospective study using an open source database, we examined the EMG activity of forearm muscles recorded from 11 transradially amputated subjects and 40 able-bodied subjects who performed a wide range of movements. By using non-negative matrix factorization, we extracted the synergistic EMG patterns for each subject to estimate the dimensionality of muscle control, under the framework of motor synergies. Results We found that amputees exhibited less than four synergies (with substantial variability related to the length of remaining limb and age), whereas able-bodied subjects commonly demonstrate five or more synergies. Conclusions The results of this study provide novel insight into the muscle synergy framework and the design of natural myoelectric control interfaces.

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“…In the recent literature, dimensionality reduction techniques have been widely used to quantify muscle coordination and to detect changes in muscle coordination following a natural or experimental event or procedure, including in pathological conditions (e.g., stroke [ 4 – 16 ]), cerebral palsy [ 17 – 19 ], Parkinson's disease [ 20 , 21 ], spinal cord injury [ 22 – 24 ], pain [ 25 – 27 ], or practicing sports [ 28 – 33 ]). These techniques represent complicated, high-dimensional muscle activations using a small number of motor modules, effectively reducing muscle activation dimensionality.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm

Roh

Beer

Lai

et al. 2018

Applied Bionics and Biomechanics

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Despite the fundamental importance of muscle coordination in daily life, it is currently unclear how muscle coordination adapts when the musculoskeletal system is perturbed. In this study, we quantified the impact of selective muscle weakness on several metrics of muscle coordination. Seven healthy subjects performed 2D and 3D isometric force target matches, while electromyographic (EMG) signals were recorded from 13 elbow and shoulder muscles. Subsequently, muscle weakness was induced by a motor point block of brachialis muscle. Postblock subjects repeated the force generation tasks. We quantified muscle coordination pre- and postblock using three metrics: tuning curve preferred direction, tuning curve area, and motor modules analysis via nonnegative matrix factorization. For most muscles, the tuning direction for the 2D protocol was not substantially altered postblock, while tuning areas changed more drastically. Typically, five motor modules were identified from the 3D task, and four motor modules were identified in the 2D task; this result held across both pre- and postblock conditions. The composition of one or two motor modules, ones that involved mainly the activation of shoulder muscles, was altered postblock. Our results demonstrate that selective muscle weakness can induce nonintuitive alternations in muscle coordination in the mechanically redundant human arm.

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Chronic pain alters spatiotemporal activation patterns of forearm muscle synergies during the development of grip force

Cited by 14 publications

References 47 publications

The influence of musculoskeletal pain disorders on muscle synergies—A systematic review

The influence of musculoskeletal pain disorders on muscle synergies—A systematic review

Dimensionality of forearm muscle activation in transradial amputees

The Effects of Selective Muscle Weakness on Muscle Coordination in the Human Arm

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