2022
DOI: 10.1038/s41380-022-01707-3
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Chronic pain causes Tau-mediated hippocampal pathology and memory deficits

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Cited by 20 publications
(9 citation statements)
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“…This study was undertaken with the hypothesis that hippocampus microstructure is a sensitive metric to relay early alterations and may provide a crucial link between aberrant neurogenesis in response to chronic pain and volumetric changes. 33 , 34 , 37 , 70 , 81 , 94 Subregion and longitudinal axis analyses identified that patients with TN have hippocampal diffusivity alterations in multiple structural and functional domains. First, we discovered subregion-specific reductions in FA, specifically contralateral subregions CA2/3 and CA4 and bilateral hippocampal body.…”
Section: Discussionmentioning
confidence: 99%
“…This study was undertaken with the hypothesis that hippocampus microstructure is a sensitive metric to relay early alterations and may provide a crucial link between aberrant neurogenesis in response to chronic pain and volumetric changes. 33 , 34 , 37 , 70 , 81 , 94 Subregion and longitudinal axis analyses identified that patients with TN have hippocampal diffusivity alterations in multiple structural and functional domains. First, we discovered subregion-specific reductions in FA, specifically contralateral subregions CA2/3 and CA4 and bilateral hippocampal body.…”
Section: Discussionmentioning
confidence: 99%
“…Hugo et al found that, compared with Tau +/+ mice, the response of Tau KO mice to acute noxious stimuli is decreased, whereas their pain-related behaviors are augmented under tonic inflammatory pain stimulation [ 9 ]. Later, they found that mice with spared nerve injury exhibit Tau hyperphosphorylation in the hippocampus owing to impaired autophagy, which in turn induces depressive-like behavior and cognitive impairment but not anxiety [ 10 , 29 ]. In the von Frey test, Tau KO mice with spared nerve injury exhibit improved cognitive impairment but no pain relief.…”
Section: Discussionmentioning
confidence: 99%
“…11 Finally, a recent study in a mouse model of chronic neuropathic pain found that chronic pain is associated with tau-mediated hippocampal atrophy and cognitive deficits. 12 To our knowledge, no study has examined the association between chronic pain status and biomarkers of neurodegeneration in the cerebrospinal fluid (CSF), and advanced neuropsychological testing. Yet, such results would not only unveil the influence of chronic pain on neuronal function but would also help identify individuals at risk for developing AD, most likely to benefit from targeted preventive measures.…”
mentioning
confidence: 99%
“…Also, a recent genome‐wide association study in the UK Biobank found that genetic variants significantly associated with multisite chronic pain are located in genes involved in neurogenesis and synaptic signaling, pathways also altered in AD 11 . Finally, a recent study in a mouse model of chronic neuropathic pain found that chronic pain is associated with tau‐mediated hippocampal atrophy and cognitive deficits 12 …”
mentioning
confidence: 99%