Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala

Narita, Minoru; Kaneko, Chris R. S.; Miyoshi, Kan; Nagumo, Yoko; Kuzumaki, Naoko; Nakajima, Mayumi; Nanjo, Kana; Matsuzawa, Kiyomi; Yamazaki, Mitsuaki; Suzuki, Tsutomu

doi:10.1038/sj.npp.1300858

Cited by 250 publications

(232 citation statements)

References 35 publications

(35 reference statements)

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“…Although the neurobiological mechanisms underlying the effects of MD on nociceptive responding in adulthood remain unknown, it has been shown that MD induces a range of sex-dependent developmental and psychoneuroimmunendocrine alterations 54 . It has been proposed that Alterations in affective responding such as anxiety-and depressive-like behaviours have been shown to be induced in a number of models of peripheral nerve injury 45,47,51,57 , although in the present study SNL failed to modulate affective behaviour. The short period following surgery over which these behaviours were examined (Day16), may account for the lack of effects as previous studies have indicated that alterations in affective behaviour only manifest after at least a month post-surgery 45,51,57 .…”

Section: Discussioncontrasting

confidence: 53%

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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Maternal deprivation is associated with sex dependant alterations in nociceptive behaviour and neuroinflammatory mediators in the rat following peripheral nerve injury. AbstractEarly-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and following peripheral nerve injury (L5-L6 spinal nerve ligation (SNL)). As neuroimmune signalling plays an important role in pain and affective disorders, associated alterations in glial and cytokine expression were assessed in key brain regions associated with emotional and nociceptive responding, the hippocampus and prefrontal cortex (PFC). MD female, but not male, rats exhibited thermal hypoalgesia and mechanical allodynia when compared to control (non-MD) counterparts. SNL resulted in mechanical and cold allodynia in MD and control rats of both sexes. However, MD females exhibited enhanced SNL-induced allodynic responding when compared to non-MD counterparts. IL-6 expression was reduced in the PFC of MD-SNL males when compared with non-SNL counterparts. GFAP and IL-1β expression in the hippocampus of MD-SNL males was increased compared with non-MD controls. MD-SNL females exhibited reduced TNFα in the PFC with a concomitant increase in IL-6 and TNFα expression in the hippocampus, compared with either MD or SNL alone. In conclusion, MD female, but not male, rats exhibit enhanced nociceptive responding following peripheral nerve injury, effects which may relate to the distinct neuroinflammatory profile observed in female versus male rats.Perspective: This study demonstrates that females rats exposed to early-life stress exhibit enhanced neuropathic pain responding, effects associated with alterations in neuroinflammatory mediators. Increased understanding of the interactions between early-life stress, gender and pain may lead to the identification o novel therapeutic targets for the treatment of chronic pain disorders.

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Section: Discussioncontrasting

confidence: 53%

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Burke

Llorente

Marco

et al. 2013

The Journal of Pain

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“…A tendency to remain in the peripheral zone of an open fi eld has been described in various animal models. 25,26) Reduced activity and exploration in OFT refl ects a deterioration of the natural behavioral tendencies of the rats and may be a result of postsurgical pain. 27) A similar pattern of behavior was observed in EPM.…”

Section: Discussionmentioning

confidence: 99%

Behavioral Changes Following Experimentally-Induced Acute Myocardial Infarction in Rats

et al. 2014

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SummaryRats with experimentally-induced acute myocardial infarction (AMI) have proven to be a clinically relevant model for visceral pain. As there are no behavioral data available on rats in the postinfarction period, we aimed to identify specifi c pain-related behavioral changes following AMI to increase the validity of the model. AMI was induced by left coronary artery ligation and pain-related behavior was analyzed using the open fi eld test (OFT) and elevated plus maze (EPM). Morphine was applied following AMI induction to differentiate pain-related changes from those related to nonspecifi c global changes in responsiveness. AMI was histologically confi rmed.Hypolocomotion was consistently evident in all behavioral tests for both the infarcted group and sham group. In the OFT, both AMI and sham rats exhibited less exploratory behavior and less activity. A similar pattern of behavior was observed in EPM, where both surgical groups showed fewer entries to the open arms and spent less time in the open arms. The sham group with an intact pericardium showed the same pattern of activity as control rats. The reduction in activity and rearing observed following AMI was successfully reversed following morphine injection. This effect was abolished after naloxone application allowing us to attribute observed changes specifi cally to pain.This study demonstrates that pain-related behavior in the acute postinfarction period is generally characterized by reduced mobility and explorative behavior. Our results showed that cardiac ischemia as a consequence of experimentally-induced infarction is a less important source of pain behavior than manipulation of the pericardium. (Int Heart J 2014; 55: 169-177) Key words: Pericardium, Postoperative pain, Behavior C hest pain is the primary and the most prominent symptom leading to the hospitalization of patients with the diagnosis of acute myocardial infarction (AMI). 1)These patients account for 20% of patients in medical emergency departments.2) However, chest pain related to AMI varies signifi cantly both in its intensity 3,4) and incidence. 5,6) In addition, the pain severity does not seem to be a good predictor of the outcome of myocardial infarction. 7)While the evaluation of pain in humans is predominantly based on conscious perception, in animals it relies mainly on behavioral output. 8) Defined by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience, 9) pain cannot be determined in animals, so proxy indicators are typically used. In order to increase the translational value of their studies, pain researchers working with experimental animals have focused more on complex behavioral responses and operant measures.10,11) Visceral pain models, eg, models of cardiac ischemia, delineate well these challenges. Pain elicited in these models is vague, with no specifi c region to focus pain measurements on, so broader behavioral and cognitive analysis is necessary to detect potential changes.12)The most commonly used stimuli i...

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“…When pain becomes chronic, the sensory dysfunction is accompanied by several brain disorders, such as anxiety, amnesia and depression (Ling et al, 2007;Narita et al, 2006). Cumulative behavioral, electrophysiological and molecular data suggested important roles for the hippocampal formation (HF) in pain process (Cecarelli et al, 1999;Liu & Chen, 2009).…”

Section: Introductionmentioning

confidence: 99%

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

Venâncio¹,

Marchioro²,

Estavam³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 μM)-and capsaicin (2.5 µg)-induced orofacial nociception models in mice. The involvement of these substances was further evaluated on the neuronal excitability of the hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO and by LIN (50, 100, and 200 mg/kg, i.p.), morphine (5 mg/kg, i.p.) and vehicle (saline + Tween 80 0.2%), before injection of nociceptive agent into the right upper lip (perinasal area). The LEO and LIN reduced the nociceptive face-rubbing behaviour in both phases on formalin test. LEO and LIN, at high doses, produced significantly antinociceptive effect in the capsaicin and glutamate tests. In hippocampal slices, LEO inhibited the population spike generated by stimulation of the hylus (antidromic stimulation), with an IC50 of 0.1±0.05 mg/mL. This response was reversibly blocked by lidocaine (0.5 mg/mL), a known voltage-dependent sodium channel antagonist and by LIN (0.5 mg/mL). Our results suggest that LEO and LIN modulate neurogenic and inflammatory pain in the tests of orofacial nociception induced by formalin, capsaicin and glutamate. Part of these effects may be associated with decreased peripheral and central neuronal excitability.

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Chronic Pain Induces Anxiety with Concomitant Changes in Opioidergic Function in the Amygdala

Cited by 250 publications

References 35 publications

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury

Behavioral Changes Following Experimentally-Induced Acute Myocardial Infarction in Rats

Ocimum basilicum leaf essential oil and (-)-linalool reduce orofacial nociception in rodents: a behavioral and electrophysiological approach

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