Chronic pain is associated with a brain aging biomarker in community-dwelling older adults

Cruz-Almeida, Yenisel; Fillingim, Roger B.; Riley, Joseph L.; Woods, Adam J.; Porges, Eric; Cohen, Ronald A.; Cole, James R.

doi:10.1097/j.pain.0000000000001491

Cited by 74 publications

(97 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Very recently, Cruz-Almeida and co-workers published a comparison of brain age delta between 33 elderly individuals with chronic pain (mean age: 70.6 ± 5.5 years) and 14 individuals without chronic pain (mean age: 71.5 ± 7.3 years). While the mean predicted brain age was smaller than the chronological brain age in both groups (p = 0.592), participants with chronic pain had a larger brain age delta after adjustment for chronological age, sex, and exercise levels (ANCOVA, F [1,41] = 4.9; p = 0.033) (35). There are major differences between Cruz-Almeida et al's study and our study.…”

Section: Discussioncontrasting

confidence: 85%

No evidence for accelerated brain aging in patients with chronic non-cancer pain

Sörös

Bantel

2019

Preprint

View full text Add to dashboard Cite

Chronic pain is often associated with changes in brain structure and function, and also cognitive deficits. It has been noted that these chronic pain-related alterations may resemble changes found in healthy aging, and thus may represent accelerated or pre-mature aging of the brain. Here we test the hypothesis that patients with chronic non-cancer pain demonstrate accelerated brain aging compared to healthy control subjects. The predicted brain age of 59 patients with chronic pain (mean chronological age ± standard deviation: 53.0 ± 9.0 years; 43 women) and 60 pain-free healthy controls (52.6 ± 9.0 years; 44 women) was determined using the software brainageR. This software segments the individual T1-weighted structural MR images into gray and white matter and compares gray and white matter images to a large (n = 2001) training set of structural images, using machine learning. Finally, brain age delta, which is the predicted brain age minus chronological age, was calculated and compared across groups. This study provided no evidence for the hypothesis that chronic pain is associated with accelerated brain aging (Welch's t-test, p = 0.74, Cohen's d = 0.061). A Bayesian independent samples t-test indicated moderate evidence in favor of the null hypothesis (BF01 = 4.875, i.e. group means were equal). Our results provide indirect support for recent models of pain related-changes of brain structure, brain function, and cognitive functions. These models postulate network-specific maladaptive plasticity, rather than wide-spread or global neural degeneration, leading to synaptic, dendritic, and neuronal remodeling. chronic pain | musculoskeletal disorders | rheumatic disease | magnetic resonance imaging | brain structure | gray matter | white matter | aging Correspondence: peter.soros@gmail.com

show abstract

Section: Discussioncontrasting

confidence: 85%

No evidence for accelerated brain aging in patients with chronic non-cancer pain

Sörös

Bantel

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Community-dwelling older adults with chronic pain had lower whole-brain fractional anisotropy (Cruz-Almeida et al, 2017) and higher white matter hyperintensity burden compared to age-matched controls (Buckalew et al, 2008;Cruz-Almeida et al, 2017). Recent evidence also suggested that chronic pain was associated with added "age-like" brain atrophy in relatively healthy older individuals using whole-brain measures of gray and white matter volume (Cruz-Almeida et al, 2019), further supporting associations between pain and brain morphology in aging.…”

Section: Associations Between Susceptibility To Chronic Pain and Age-mentioning

confidence: 96%

Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Lussier

Cruz-Almeida

Ebner

2019

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Chronic pain disproportionately affects older adults, severely impacting quality of life and independent living, with musculoskeletal pain most prevalent. Chronic musculoskeletal pain is associated with specific structural alterations in the brain and interindividual variability in brain structure is likely an important contributor to susceptibility for the development of chronic pain. However, understanding of age-related structural changes in the brain and their associations with chronic musculoskeletal pain is currently limited. Oxytocin (OT), a neuropeptide present in the periphery and central nervous system, has been implicated in pain attenuation. Variation of the endogenous OT system (e.g., OT receptor genotype, blood, saliva, and cerebrospinal fluid OT levels) is associated with morphology in brain regions involved in pain processing and modulation. Intranasal OT administration has been shown to attenuate pain. Yet, studies investigating the efficacy of OT for management of chronic musculoskeletal pain are lacking, including among older individuals who are particularly susceptible to the development of chronic musculoskeletal pain. The goal of this focused narrative review was to synthesize previously parallel lines of work on the relationships between chronic pain, brain morphology, and OT in the context of aging. Based on the existing evidence, we propose that research on the use of intranasal OT administration as an intervention for chronic pain in older adults is needed and constitutes a promising future direction for this field. The paper concludes with suggestions for future research in the emerging field, guided by our proposed Model of Oxytocin's Anagelsic and Brain Structural Effects in Aging.

show abstract

“…On the other hand, fibromyalgia has been related to alterations in gray and white matter volume in certain areas of the brain [260]. Another study in older people has shown an association between chronic pain and brain atrophy [44].…”

Section: Functional Magnetic Resonance Imaging (Fmri) and Chronic Painmentioning

confidence: 99%

“…It should be noted that despite the lack of an objective reference for the evaluation of chronic pain, many studies have tried to induce pain levels in a controlled manner (by heat [23,[41][42][43][44][45][46][47][48][49][50][51][52][53], cold [45,48,52], pressure [44] or electrical stimulation [54]) as a first approximation to a method that allows the evaluation of chronic pain [1]. In contrast to the studies based on research with phasic pain stimuli (short duration), the number of studies based on tonic pain stimuli is growing as an approach to chronic pain [23,[41][42][43][44][45][46][47][48][49][50][51][52][52][53][54][55]. This validation approach represents an objective way for assessing chronic pain, leaving aside all the subjectivity that may be related to the perception of pain by the chronic patient [23,[41][42][43][44][45][46]…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to the studies based on research with phasic pain stimuli (short duration), the number of studies based on tonic pain stimuli is growing as an approach to chronic pain [23,[41][42][43][44][45][46][47][48][49][50][51][52][52][53][54][55]. This validation approach represents an objective way for assessing chronic pain, leaving aside all the subjectivity that may be related to the perception of pain by the chronic patient [23,[41][42][43][44][45][46][47][48][49][50][51][52][52][53][54][55]. In addition, it becomes the most appropriate option in the case of patients with absence of communication skills, whether verbal, written or tactile (infants, unconscious patients, critically sick, patients with intellectual impairment, advanced dementia, etc.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review

Naranjo-Hernández

Reina‐Tosina

Roa

2020

Sensors

View full text Add to dashboard Cite

Non-oncologic chronic pain is a common high-morbidity impairment worldwide and acknowledged as a condition with significant incidence on quality of life. Pain intensity is largely perceived as a subjective experience, what makes challenging its objective measurement. However, the physiological traces of pain make possible its correlation with vital signs, such as heart rate variability, skin conductance, electromyogram, etc., or health performance metrics derived from daily activity monitoring or facial expressions, which can be acquired with diverse sensor technologies and multisensory approaches. As the assessment and management of pain are essential issues for a wide range of clinical disorders and treatments, this paper reviews different sensor-based approaches applied to the objective evaluation of non-oncological chronic pain. The space of available technologies and resources aimed at pain assessment represent a diversified set of alternatives that can be exploited to address the multidimensional nature of pain.

show abstract

Chronic pain is associated with a brain aging biomarker in community-dwelling older adults

Cited by 74 publications

References 40 publications

No evidence for accelerated brain aging in patients with chronic non-cancer pain

No evidence for accelerated brain aging in patients with chronic non-cancer pain

Musculoskeletal Pain and Brain Morphology: Oxytocin’s Potential as a Treatment for Chronic Pain in Aging

Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review

Contact Info

Product

Resources

About