Chronic pain produces hypervigilance to predator odor in mice

Lister, Kevin C.; Bouchard, Sioui Maldonado; Markova, Teodora; Aternali, Andrea; Denecli, Pelin; Pimentel, Stephania Donayre; Majeed, Mariam R; Austin, Jean-Sébastien; Williams, Amanda C de C; Mogil, Jeffrey S.

doi:10.1016/j.cub.2020.06.025

Cited by 27 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This mechanism should have evolutional significance by elevating the vigilance level in response to ongoing injury/inflammation to protect against the further risk to survival. 23 , 52 …”

Section: Discussionmentioning

confidence: 99%

Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain

Sugimoto

Takahashi

Sugimura

et al. 2021

Pain

View full text Add to dashboard Cite

show abstract

“…This mechanism should have evolutional significance by elevating the vigilance level in response to ongoing injury/inflammation to protect against the further risk to survival. 23 , 52 …”

Section: Discussionmentioning

confidence: 99%

Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain

Sugimoto

Takahashi

Sugimura

et al. 2021

Pain

View full text Add to dashboard Cite

show abstract

“…Persistent activation or malfunction of this nociceptive system gives rise to chronic pain. While chronic pain is generally considered to be maladaptive, this concept has recently been challenged (Crook et al, 2014;Lister et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Neuroimmunology of Chronic Pain: From Rodents to Humans

et al. 2020

View full text Add to dashboard Cite

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.

show abstract

“…Acute pain is considered an alarm system for protecting body integrity, while chronic pain may serve an adaptative role (Crook et al, 2014;Lister et al, 2020). In spite of its role, chronic pain is a major health problem around the world with a prevalence up to 50% (Fayaz et al, 2016;Manion et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

et al. 2020

View full text Add to dashboard Cite

Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent. The search for the mechanism of action of metformin has produced an enormous amount of research to explain its effects on gluconeogenesis, protein metabolism, fatty acid oxidation, oxidative stress, glucose uptake, autophagy and pain, among others. It was only up the end of the 1990s and beginning of this century that some of its mechanisms were revealed. Metformin induces its beneficial effects in diabetes through the activation of a master switch kinase named AMP-activated protein kinase (AMPK). Two upstream kinases account for the physiological activation of AMPK: liver kinase B1 and calcium/ calmodulin-dependent protein kinase kinase 2. Once activated, AMPK inhibits the mechanistic target of rapamycin complex 1 (mTORC1), which in turn avoids the phosphorylation of p70 ribosomal protein S6 kinase 1 and phosphatidylinositol 3kinase/protein kinase B signaling pathways and reduces cap-dependent translation initiation. Since metformin is a disease-modifying drug in type 2 diabetes, which reduces the mTORC1 signaling to induce its effects on neuronal plasticity, it was proposed that these mechanisms could also explain the antinociceptive effect of this drug in several models of chronic pain. These studies have highlighted the efficacy of this drug in chronic pain, such as that from neuropathy, insulin resistance, diabetic neuropathy, and fibromyalgia-type pain. Mounting evidence indicates that chronic pain may induce anxiety, depression and cognitive impairment in rodents and humans. Interestingly, metformin is able to reverse some of these consequences of pathological pain in rodents. The purpose of this review was to analyze the current evidence about the effects of metformin in chronic pain and three of its comorbidities (anxiety, depression and cognitive impairment).

show abstract

Chronic pain produces hypervigilance to predator odor in mice

Cited by 27 publications

References 8 publications

Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain

Active role of the central amygdala in widespread mechanical sensitization in rats with facial inflammatory pain

The Neuroimmunology of Chronic Pain: From Rodents to Humans

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

Contact Info

Product

Resources

About