Chronic Pancreatitis and Systemic Lupus Erythematosus: An Uncommon Association

Gutiérrez, Sílvia; Casas, Horacio; Cremaschi, Maria Blanca; Valenzuela, Marcela Liliana; Cubilla, Ariel Adalberto; García, Adriana Moreno

doi:10.1159/000112861

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…The spectrum of SLE is not solely restricted to acute pancreatitis as the association of SLE with chronic pancreatitis has been reported as well [6]. In addition to her acute pancreatitis, the index case also developed features of acute autoimmune hemolytic anemia during her hospital stay.…”

Section: Discussionmentioning

confidence: 88%

“…The combination of SLE and acute pancreatitis is a very serious complication, which could even be fatal, as reported by Cairoli et al [ 5 ]. The spectrum of SLE is not solely restricted to acute pancreatitis as the association of SLE with chronic pancreatitis has been reported as well [ 6 ]. In addition to her acute pancreatitis, the index case also developed features of acute autoimmune hemolytic anemia during her hospital stay.…”

Section: Discussionmentioning

confidence: 99%

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The simultaneous incidence of acute pancreatitis and autoimmune hemolytic anemia: a rare duo in a patient with SLE

Masoodi

2014

GMS German Medical Science; 12:Doc12; ISSN 1612-3174

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

The simultaneous incidence of acute pancreatitis and autoimmune hemolytic anemia: a rare duo in a patient with SLE

Masoodi

2014

GMS German Medical Science; 12:Doc12; ISSN 1612-3174

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“…), or bacterial infections, should be excluded. Anti-smooth muscle, anti-liver-kidney microsomal, or anti-mitochondrial antibodies should be investigated 23 . Similarly, in our patient, acute pancreatitis was related to SLE in terms of immunological manifestations with concomitant multiorgan manifestations after excluding frequent etiologias.…”

Section: Discussionmentioning

confidence: 99%

Unusual Presentation of Systemic Lupus Erythematosus with Acute Pancreatitis: A Case Report

Alanazi,

Hameed Alreshidi,

Fahad Aldhamadi

et al. 2023

Int J Life Sci Pharm Res

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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease affecting any organ with diverse clinicalmanifestations. Lupus-related acute pancreatitis (AP) is a serious cause of SLE-induced acute abdominal discomfort, along with lupusmesenteric vasculitis. Systemic Lupus Erythematosus (SLE) is a complex and chronic autoimmune disease characterized by its ability toaffect virtually any organ system, resulting in a wide array of clinical manifestations. One particularly severe complication associatedwith SLE is lupus-related acute pancreatitis (AP), which can cause acute abdominal discomfort. Lupus mesenteric vasculitis is anotherabdominal manifestation of SLE, further highlighting the systemic nature of the disease. Lupus pancreatitis is more common in femalesand the third decade of life, with an incidence ranging from 0.7% to 4%. This case report describes a 16-year-old Saudi female whopresented to the emergency department with episodic fever, epigastric abdominal pain, sweating, loss of appetite, and diarrhoea,among other symptoms. Her laboratory test results showed leukopenia, anaemia, increased liver, and pancreatic enzyme levels,increased inflammatory markers, and hypocomplementemia. She was diagnosed with lupus pancreatitis after ruling out other potentialcauses. Treatment included steroids and hydroxychloroquine. The patient showed marked improvement in resolving all symptoms,emphasizing the need for prompt diagnosis and management. This case insists on timely diagnosis and appropriate management inmitigating the potentially severe consequences of lupus pancreatitis and other SLE-related complications. In conclusion, SLE is amultifaceted autoimmune condition that affects various organs, including the pancreas, leading to conditions like lupus pancreatitis.The presented case serves as a poignant reminder of the diverse clinical presentations of SLE and highlights the crucial role of promptdiagnosis and effective management in improving patient outcomes.

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“…or bacterial infections, also testing for anti-smooth muscle, anti-liver-kidney microsomal, or anti-mitochondrial antibodies should be done. 40 The imaging evaluation by ultrasonography or computed tomography might not be relevant in all cases and so the clinical picture and laboratory monitoring is important. 7,8,12…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus-related acute pancreatitis

Dima

Balaban

Jurcuţ³

et al. 2020

Lupus

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Introduction Systemic lupus erythematosus (SLE) is a complex autoimmune pathology that can involve any organ. Lupus-related acute pancreatitis (AP) is, together with lupus mesenteric vasculitis, an important cause of SLE-induced acute abdominal pain. Methods A literature search was conducted using the terms “Pancreatitis” and “Lupus Erythematosus, Systemic” on PubMed/Medline and Web of Science from January 2007 to January 2020. Clinical characteristics, diagnostic approach, and treatment principles in SLE-related AP are presented in this review. Results Mainly retrospective reports were identified. The reported incidence of SLE-associated AP ranges from 0.9 to more than 5% of patients. A total of 264 SLE patients were found in the selected research, with a net female predominance (sex ratio 9:1) and mean age of 31.4 years. Abdominal pain was virtually present in all cases. AP occurrence was more frequent in SLE patients with short disease duration, high activity scores, and multiorgan involvement. The AP definition was based on currently available guidelines and after exclusion of any other known causes (including iatrogenic, i.e. drugs), a diagnosis of “idiopathic” SLE-related AP might be sustained. Management is difficult, as there is no standardized therapeutic approach. Of note, glucocorticoid use remains still controversial as, especially for high doses, subsequent pancreatic injury may occur. Monitoring serum lipase levels after high dose steroids might be considered. One study reported beneficial prognostic effect of plasma exchange. Moreover, AP in SLE might raise awareness about macrophage activation syndrome association. Mortality up to one third of AP cases in SLE was reported. Conclusion The SLE-related AP is a rare, but severe, life-threatening complication. Corticosteroids must be used with caution. Plasma exchange could be considered in selected cases.

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Chronic Pancreatitis and Systemic Lupus Erythematosus: An Uncommon Association

Cited by 6 publications

References 20 publications

The simultaneous incidence of acute pancreatitis and autoimmune hemolytic anemia: a rare duo in a patient with SLE

The simultaneous incidence of acute pancreatitis and autoimmune hemolytic anemia: a rare duo in a patient with SLE

Unusual Presentation of Systemic Lupus Erythematosus with Acute Pancreatitis: A Case Report

Systemic lupus erythematosus-related acute pancreatitis

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