Chronic Pancreatitis with Spontaneously Disappearing Calcifications

Friedberg, Scott; Slivka, Adam; Dasyam, Anil K.; Yadav, Dhiraj

doi:10.14309/crj.2018.94

Cited by 4 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, recent observations imply that pancreatic calcifications may even spontaneously dissolve over time, although this is probably a rare event 38 .…”

Section: Risk Factors For Pancreatic Calcificationsmentioning

confidence: 99%

Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases

et al. 2019

View full text Add to dashboard Cite

Objective: Pancreatic calcifications is a common finding in patients with chronic pancreatitis (CP), but the underlying pathophysiology is incompletely understood. Past studies for risk factors of calcifications have generally been focused on single parameters or limited by small sample sizes. The aim of this study was to explore several patient and disease characteristics and their associations with pancreatic calcifications in a large cohort of CP patients with diverse etiological risk factors. Methods: This was a multicenter, cross-sectional study including 1509 patients with CP from the Scandinavian and Baltic countries. Patient and disease characteristics were compared for patients with calcifications (n=912) vs. without calcifications (n=597). Multivariable logistic regression was performed to assess the parameters independently associated with calcifications. Results: The mean age of patients was 53.9±14.5 years and 1006 (67%) were men. The prevalence of calcifications was 60.4% in the overall patient cohort, but highly variable between patients with different etiological risk factors (range: 2-69%). On multivariate analysis, alcoholic etiology (OR 1.76 [95% CI, 1.39-2.24]; p<0.001) and smoking (OR 1.77 [95% CI, 1.39-2.26], p<0.001) were positively associated with the presence of calcifications, while an autoimmune etiology was negatively associated with calcifications (OR 0.15 [95% CI, 0.08-0.27], p<0.001). Patients with pancreatic calcifications were more likely to have undergone pancreatic duct stenting (OR 1.59 [95%CI, 1.16-2.19], p=0.004). Conclusion: The presence of pancreatic calcifications is associated with etiological risk factors in patients with CP. This observation attest to the understanding of CP as a complex disease and may have implications for disease classification.

show abstract

“…Interestingly, recent observations imply that pancreatic calcifications may even spontaneously dissolve over time, although this is probably a rare event 38 .…”

Section: Risk Factors For Pancreatic Calcificationsmentioning

confidence: 99%

Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Pancreatic duct stone autolysis in the natural history of CP has been recorded in some cases. 17 It was reported that approximately 30% of CP cases presented a marked reduction of calcium deposition in the later stages of CP, and PDS autolysis is a frequent pathological process. 17 , 18 The reason behind this may be that drinking and smoking cessation partially restore the secretory functions of the pancreas.…”

Section: Discussionmentioning

confidence: 99%

“… 17 It was reported that approximately 30% of CP cases presented a marked reduction of calcium deposition in the later stages of CP, and PDS autolysis is a frequent pathological process. 17 , 18 The reason behind this may be that drinking and smoking cessation partially restore the secretory functions of the pancreas. The dissolution of PDS in this research is mainly owed to the effect of ECGG treatment because the dissolution rate of the ECGG group was significantly higher than that of the CON group ( P = .002; Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

Oral Endothelium Corneum Gigeriae Galli Therapy for Pancreatic Duct Stones: A Prospective Cohort Study

Cao¹,

Li²,

Wang³

et al. 2022

Turk J Gastroenterol

View full text Add to dashboard Cite

Background: Pancreatic duct stones obstruct the pancreatic ducts and aggravate clinical symptoms of chronic pancreatitis. Only isolated case reports have shown that some drugs may be useful in dissolving pancreatic duct stones. Endothelium corneum gigeriae galli is a Chinese medicine widely used to cure multifarious lithiasis and maldigestion. This study aimed to evaluate the efficacy of endothelium corneum gigeriae galli oral therapy in the dissolution of stones and evaluate the improvement of clinical symptoms in patients with pancreatic duct stones. Methods: Sixty-eight patients with pancreatic duct stones were randomly divided into the endothelium corneum gigeriae galli and control groups. Endothelium corneum gigeriae galli was given orally to the endothelium corneum gigeriae galli group, and the placebo was given to the control group. Both groups were reviewed by computed tomography and magnetic resonance imaging; abdominal pain, exocrine and endocrine pancreatic function, and the nutritional status of patients were measured after the study. Results: The dissolution rate of the endothelium corneum gigeriae galli group was significantly higher than that of the control group ( P = .002). The abdominal pain of the endothelium corneum gigeriae galli group was relieved more significantly compared to that of the control group ( P < .001). The exocrine and endocrine pancreatic function of the endothelium corneum gigeriae galli group improved more significantly than that of the control group ( P < .001). The nutritional status of the endothelium corneum gigeriae galli group was significantly higher than that of the control group ( P = .003). Conclusion: Overall, oral endothelium corneum gigeriae galli treatment could dissolve pancreatic duct stones, relieve abdominal pain, improve exocrine and endocrine pancreatic functions, and control the deterioration of nutritional status. Endothelium corneum gigeriae galli treatment should be useful in pancreatic duct stones therapy.

show abstract

“…We are not aware of any serial investigations of pancreatic duct morphology over time to compare this finding with. Anecdotal evidence suggests that pancreatic duct obstruction may resolve spontaneously ( 32 ). However, according to our observations, this is a relatively rare event, and as such, pancreatic duct morphology does not change in most medically managed patients with CP.…”

Section: Discussionmentioning

confidence: 99%

Clinical Course of Medically Managed Patients With Large and Small Duct Chronic Pancreatitis

Mahdi

Steinkohl

Singh

et al. 2022

Clin Transl Gastroenterol

View full text Add to dashboard Cite

INTRODUCTION: Pancreatic duct obstruction is the primary indication for endoscopic and/or surgical therapy in patients with chronic pancreatitis (CP). However, the clinical course of medically managed patients in relation to pancreatic duct obstruction is largely unknown. METHODS: This was a retrospective cohort study of medically managed patients with CP. We classified patients based on pancreatic duct obstruction from a stricture or stone using cross-sectional imaging (i.e., large vs small duct CP). We compared prevalence of diabetes and exocrine insufficiency (EPI) between subgroups at inclusion and investigated risk of new-onset diabetes, EPI, and all-cause mortality over a follow-up period of 5 years. Changes in pancreatic morphology were studied in patients who underwent follow-up imaging. RESULTS: A total of 198 patients (mean age 58 ± 12 years, 70% male, 60% alcoholic etiology, 38% large duct CP) were evaluated. At inclusion, patients with large vs small duct CP had a higher prevalence of both diabetes (43% vs 24%, P = 0.004) and EPI (47% vs 28%, P = 0.007). There was an increased risk of new-onset EPI in patients with large duct CP (hazard ratio 1.72; 95% confidence interval [1.05–2.80], P = 0.031) and higher rates of pancreatic atrophy ( P < 0.001). No differences between groups were observed for new-onset diabetes and all-cause mortality. Conversion from small to large duct CP or vice versa during follow-up was observed in 14% of patients. DISCUSSION: In a medically managed cohort of patients, large duct CP was associated with increased risk of EPI and pancreatic atrophy compared with small duct CP.

show abstract

Chronic Pancreatitis with Spontaneously Disappearing Calcifications

Cited by 4 publications

References 7 publications

Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases

Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases

Oral Endothelium Corneum Gigeriae Galli Therapy for Pancreatic Duct Stones: A Prospective Cohort Study

Clinical Course of Medically Managed Patients With Large and Small Duct Chronic Pancreatitis

Contact Info

Product

Resources

About