Chronic Periodontal Disease and Systemic Inflammation on Endothelial Dysfunction in Untreated Hypertensive Patients: PP.2.53

Abstract

Objective: Current cardiovascular risk assessment in primary prevention results in over and under treatment of individual patients although on an epidemiological level benefit has been shown. A trend towards personalized medicine is emerging assuming considerable inter-individual atherosclerotic variation. After risk categorization, further individualized diagnostic workup may be feasible. We hypothesized that carotid artery vessel wall (CAVW) assessment using 3 Tesla MRI could show atherosclerotic variation in a homogeneous group stratified for cardiovascular risk.Design and Method: One hundred and sixteen men (age 59.0 AE 5.18years) with visceral obesity and CRP ¼>1.8 mg/L were included. Patients were selected for not having suffered from a cardiovascular event. In all individuals the predicted 10-year risk of mortality due to CVD was assessed using Framingham scores. Patients were stratified according to their risk score as follows: 5-9%, 10-14%, 15-19% and ¼>20%/10 years risk .CAVW characteristics were assessed using black blood 3T MR vessel wall imaging, a precise and reproducible technique (JMRI 2007; 25:1035-43).

The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease

“…ADMA is an endogenous inhibitor of nitric oxide synthase (which converts the amino acid L-arginine into nitric oxide), thus inhibiting key roles of nitric oxide in vascular homeostasis [38]. ADMA is elevated in CKD [39] and in settings of increases oxidative stress, such as periodontal disease [40]. ADMA is also a marker of CKD progression.…”