Chronic periodontitis and its possible association with oral squamous cell carcinoma – a retrospective case control study

Abstract

IntroductionDifferent inflammatory processes may trigger the development of malignancies. Therefore, the aim of the present study was to evaluate a potential association between radiological determined chronic periodontitis (CPA) and oral squamous cell carcinoma (OSCC).MethodsIn a retrospective study, OSCC-patients and a control group without malignant tumors were radiographically examined for bone loss. Via telephone survey and questionnaire, general clinical data on the individual oral hygiene and concomitant diseases together with tobacco and alcohol use were assessed and data were compared between the groups.Results178 OSCC-patients and 123 controls were included. In univariate analysis, a statistically relevant higher mean bone loss was seen in the OSCC group (4.3 mm (SD: 1.8; 95% confidence interval (CI): 4-4.6) vs. 2.9 mm (SD: 0.7; 95% CI: 2.8-3); p < 0.001)). This was confirmed in a multivariate regression model (OR: 2.4, 95% CI: 1.5-3.8; p < 0.001). A history of periodontal treatment was associated with significantly reduced OSCC risk (p < 0.001; OR: 0.2, CI: 0.1-0.5).ConclusionsCPA is a common disease and the monitoring as well as the treatment of such a chronic oral inflammation may be beneficial in reducing one potential cause of OSCC. Therefore, further clinical studies on oral neoplasms should consider clinical periodontal parameters as well.

Neutrophils and oral squamous cell carcinoma: lessons learned and future directions

“…Another important question is whether the modulation of neutrophil activity can influence the development or prognosis of oral cancers. There is evidence to suggest that the maintainence of good oral hygiene and therefore, low neutrophil counts in the saliva correlates with a small prevalence of oral cancer [84,90]. Finally, oral cancers are amenable to treatments that modulate neutrophil function locally, as the oral cavity is a readily accessible site.…”

Oral health and human papillomavirus‐associated head and neck squamous cell carcinoma

“…Oral health indicators, including poor dental health, tooth loss, lack of routine dental care by a dentist, and a diagnosis of periodontitis, have been associated with HNSCC . Two studies reported that periodontitis is associated with an increased risk of OPSCC without taking into account HPV status . Only 2 case‐only studies have examined the association between oral health and malignancy by comparing HPV‐positive OPSCC with HPV‐negative OPSCC.…”

“…[9][10][11][12][13] Two studies reported that periodontitis is associated with an increased risk of OPSCC without taking into account HPV status. 10,14 Only 2 case-only studies have examined the association between oral health and malignancy by comparing HPV-positive OPSCC with HPV-negative OPSCC. Both of those studies reported a positive association between periodontitis and HPV-positive OPSCC compared with HPV-negative OPSCC.…”

Existe associação entre doença periodontal e câncer? Análise investigativa clínica

“…• questionários sobre cuidados com higiene oral e consultas odontológicas (ZHENG et al, 1990;WINN et al, 1991;MARSHALL et al, 1992;BUNDGAARD et al, 1995;VELLY et al, 1998;MORENO-LOPEZ et al, 2000;GARROTE et al, 2001;GUHA et al, 2007;REZENDE et al, 2008;HOLMES et al, 2009;DIVARIS et al, 2010;ELIOT et al, 2013;MOERGEL et al, 2013;NARAYAN et al, 2014);…”

“…• mensurações radiográficas da distância entre crista alveolar e junção cemento-esmalte (TEZAL et al, 2007;TEZAL et al, 2009b;TEZAL et al, 2009a;MOERGEL et al, 2013);…”