Chronic Periodontitis and the Potential Likelihood of Gastric Cancer: A Nested Case-Control Study in the Korean Population Utilizing a National Health Sample Cohort

Abstract

There is limited information regarding the potential association between chronic periodontitis (CP) and gastric cancer, especially in the Korean population. This study aimed to explore this relationship. This nested case–control study analyzed data from 10,174 patients with gastric cancer and 40,696 controls from the Korean National Health Insurance Service–National Sample Cohort using propensity score matching. Standardized differences were used to compare baseline characteristics between study groups. Logistic regression analyses adjusted for confounders were conducted to assess the association between history of CP and gastric cancer occurrence. CP histories and comprehensive subgroup analyses in the 1- and 2-year periods preceding the index date were evaluated. Individuals with a history of CP within the 1-year and 2-year periods showed an increased likelihood of developing gastric cancer. Subgroup analyses consistently supported these findings in male participants aged <65 years and individuals with various income levels or living in residential areas. However, no significant associations were observed among participants aged ≥65 years. In conclusion, CP may be a potential risk factor for gastric cancer development in the Korean population. Regular screening for gastric cancer may be necessary for high-risk individuals, specifically men aged <65 years with a history of CP.

Investigating the Connection between Chronic Periodontitis and Parkinson’s Disease: Findings from a Korean National Cohort Study

“…Metabolic syndrome includes various cardiovascular disease-specific risk factors like abdominal obesity, hypertension, diabetes, and hypertriglyceridemia [44]. CP is linked to chronic conditions like chronic kidney disease, cardiovascular disease, diabetes, hyperlipidemia, and malignancy [9][10][11][12]20,45], all of which are considered in CCI scores [38]. Hypertension, diabetes, dyslipidemia, ischemic stroke, hemorrhagic stroke, ischemic heart disease, depression, osteoporosis, and obesity have all been independently linked to a heightened risk of PD in the Korean population [14], collectively accounting for a substantial portion (20.4%) of the population-attributable fraction in PD development [14].…”

“…Patients with CP may share common risk factors, such as smoking, sex, ethnicity, oxidative stress, chronic inflammation, and aging, which are also associated with those health conditions [6,9,10,20,22,45,46]. These shared risk factors might contribute to potential common underlying mechanisms, such as systemic metabolic changes accompanied by heightened oxidative stress and ongoing inflammatory conditions [13].…”

The Association of Chronic Periodontitis as a Potential Risk Factor with Rheumatoid Arthritis: A Nested Case-Control Study Using a Korean National Health Screening Cohort

“…The frequency of clinic or hospital visits related to CP treatment was recorded annually and aggregated over a two-year period before the index date to provide a comprehensive representation of treatment patterns. This meticulous approach aimed to strengthen the relationship between CP and the investigated outcomes [39].…”