Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Zhang, Dongxue; Liu, Wenyan; Miao, Ran; Wang, Lei; Zhou, Xuan; Wang, Haiyan; Li, Yufeng; Wang, Zuomin

doi:10.1055/a-0895-5275

Cited by 9 publications

(11 citation statements)

References 28 publications

(26 reference statements)

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“…Studies have shown that periodontitis contributes to the development and progression of DN. Our previous study showed that percent of sites with PD ≥4 mm was positively associated with risk for renal dysfunction in patients with DM 26 . Accordingly, in this study, PD and percent of sites with PD ≥4 mm were positively correlated with ACR in T2DN patients with periodontitis and dyslipidemia, suggesting a relationship between periodontal inflammation, blood lipid control, and renal dysfunction among T2DN patients.…”

Section: Discussionsupporting

confidence: 64%

Relationship between periodontal status and dyslipidemia in patients with type 2 diabetic nephropathy and chronic periodontitis: A cross‐sectional study

Zhang

Chen

Liu

et al. 2022

J of Periodontal Research

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Objective:The aim of this study was to investigate the association between periodontitis and total serum cholesterol level in patients with type 2 diabetic nephropathy (T2DN). Background:Periodontitis is now recognized as the sixth complication of diabetes and can also affect other complications of diabetes, including nephropathy and coronary artery diseases. Studies have considered dyslipidemia as a risk factor for exacerbation of periodontitis.Methods: A total of 119 T2DN patients with chronic periodontitis were included in this observational study. Participants were stratified into the Normal (serum total cholesterol <5.17 mmol/L, n = 89) and the Dyslipidemia groups (serum total cholesterol ≥5.17 mmol/L, n = 30). Participants completed a validated questionnaire that collected information on oral hygiene behaviors and knowledge of oral health and underwent a clinical oral examination. The number of remaining teeth, probing depth (PD), clinical attachment level (CAL), and bleeding index (BI) was recorded.Physical examination and laboratory tests (fasting plasma glucose, serum glycosylated hemoglobin (HbA1c), total cholesterol, high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglyceride, and high-sensitivity Creactive protein levels) were performed.Results: Means of CAL and BI were significantly higher in the Dyslipidemia group compared with the Normal group. In the Dyslipidemia group, PD and percent of sites with PD ≥4 mm were positively correlated with urinary albumin/creatinine ratios; PD and percent of sites with PD ≥4 and PD ≥5 mm were positively correlated with HbA1c level; a number of remaining teeth were negatively correlated with serum LDL-C level.After adjusting for age, gender, body mass index, smoking, FPG, and serum HbA1c and triglyceride levels, BI was found to be positively associated with dyslipidemia in T2DN patients with periodontitis.

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Section: Discussionsupporting

confidence: 64%

Relationship between periodontal status and dyslipidemia in patients with type 2 diabetic nephropathy and chronic periodontitis: A cross‐sectional study

Zhang

Chen

Liu

et al. 2022

J of Periodontal Research

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“…The results of our research did not show significant difference in periodontal status between the two groups. There are probably several reasons for this, one of them being the fact that the control group comprised subjects with only one to two grades of milder CKD, and this difference may not be sufficient to affect periodontal status significantly 31 .…”

Section: Discussionmentioning

confidence: 99%

Periodontal Disease in Different Stages of Chronic Kidney Disease

Kopić

Barbić

Petrović

et al. 2019

ACC

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-Periodontal disease is a chronic multifactorial disease the worldwide incidence of which is higher than the incidence of caries and represents one of the leading problems in dental medicine. It is manifested by the loss of the attachment apparatus of the tooth and leads to the loss of teeth. Numerous studies have shown the association of periodontal disease and various chronic systemic diseases such as diabetes mellitus and cardiovascular disease. It is believed that low-grade level of chronic inflammation and release of bacterial toxins and inflammatory mediators in the bloodstream aggravate a chronic systemic disease. The purpose of our research was to investigate the possible association of periodontal disease and chronic kidney disease via the inflammatory cytokines path. In this cross-sectional study, we surveyed a total of 80 subjects divided into two groups. First group included subjects with chronic renal disease stages III and IV, and the second group included patients with chronic renal disease stage V that were on hemodialysis. We compared periodontal status, as well as serum levels of different cytokines, interleukin 6, interleukin 17A and tumor necrosis factor α between the two groups. The results showed no significant between-group differences in periodontal status, but interleukin 6 levels were significantly higher in the hemodialysis group of patients and were also associated with a poorer periodontal status.

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“…Chronic periodontitis (CP) is an inflammatory and destructive disease with multiple microbial sources and is characterized by gingival inflammation, periodontal attachment loss, alveolar bone resorption and periodontal pocket formation [ 6 , 7 ]. The natural history of CP slowly progresses from the early gingivitis stage to irreversible severe periodontitis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic periodontitis in patients undergoing peritoneal dialysis and its correlation with peritoneal dialysis-related complications

et al. 2023

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Objective The microinflammatory state can influence the occurrence of dialysis-related complications in dialysis patients. Chronic periodontitis (CP), in which plaque biofilm is considered to be the initiating factor, is a chronic infectious disease in the oral cavity. It is still uncertain whether CP affects the microinflammatory state in peritoneal dialysis (PD) and the occurrence of dialysis-related complications. The purpose of this study was to investigate the correlation between the periodontal index and clinical parameters in peritoneal dialysis patients with CP and dialysis-related complications, including peritoneal dialysis-associated peritonitis (PDAP) and cardiovascular and cerebrovascular events (CCEs). Methods This was a retrospective cohort study, and 76 patients undergoing PD were enrolled. Clinical parameters, the occurrence of PD-related complications and periodontitis-related indicators, including the gingival index (GI), plaque index (PLI), probing depth (PPD) and clinical attachment loss (CAL), were collected. Correlation analysis was used to explore the correlation between periodontal or clinical parameters and the occurrence of PD-related complications. Results All the patients had different degrees of periodontitis (mild 9.2%, moderate 72.4%, severe 18.4%); PPD was inversely related to serum albumin (r = − 0.235, p = 0.041); CAL has a positive correlation with serum C-reactive protein (rs = 0.242, p = 0.035); PLI was positively correlated with serum calcium (r = 0.314, p = 0.006). ANOVA, multivariate logistic regression analysis and Kaplan-Meier Survival curve suggested that CAL was a risk factor for the occurrence of PDAP. There was no correlation between periodontal parameters and CCEs or poor prognosis. Conclusion CP is universally present in PD patients, and the presentation of periodontitis influences the systemic inflammatory state in PD patients. CP is a risk factor for PDAP.

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Chronic Periodontitis is a Risk Factor of Renal Dysfunction in Patients with Type 2 Diabetes

Cited by 9 publications

References 28 publications

Relationship between periodontal status and dyslipidemia in patients with type 2 diabetic nephropathy and chronic periodontitis: A cross‐sectional study

Relationship between periodontal status and dyslipidemia in patients with type 2 diabetic nephropathy and chronic periodontitis: A cross‐sectional study

Periodontal Disease in Different Stages of Chronic Kidney Disease

Prevalence of chronic periodontitis in patients undergoing peritoneal dialysis and its correlation with peritoneal dialysis-related complications

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