Chronic pharmacological treatment in takotsubo cardiomyopathy

Fazio, Giovanni; Pizzuto, Caterina; Bárbaro, Giuseppe; Sutera, Loredana; Incalcaterra, Egle; Evola, G; Azzarelli, Salvatore; Paleček, Tomáš; Gesaro, Gabriele Di; Cascio, Caterina; Novo, Giuseppina; Akashi, Yoshihiro J.; Novo, Salvatore

doi:10.1016/j.ijcard.2007.04.013

Cited by 46 publications

(43 citation statements)

References 21 publications

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“…TTC was rarely described in the male population, representing less than 10% of all the cases (Bybee et al, 2004;Tsuchihashi et al, 2001;Sharkey et al, 2005;Akashi et al, 2008;Kurowski et al, 2007). In this population, cardiac risk factors seem to be less described, whereas highest prevalence of anxiety or depression was reported (Kurowski et al, 2007;Vidi et al, 2009;Mudd et al 2007;Pace et al, 2011).…”

Section: Populationmentioning

confidence: 96%

“…This neuro-hormonal hypothesis including catecholamine excess and exaggerated stimulation of the sympathetic nervous system is supported by several studies showing that patients with TTC have supraphysiologic and higher levels of plasma catecholamines than patients with acute coronary syndrome (Wittstein et al, 2005) Moreover, several cases have been described after administration of exogenous cathecolaminergic agents such as dobutamine (Previtali et al, 2005;Abraham et al, 2009;Cherian et al, 2008;Winogradow et al, 2010). However, other studies have documented no significant elevation in plasma catecholamine levels in TTC patients (Bybee et al, 2004;Gianni et al, 2006;Tsuchihashi et al, 2001;Kawai et al, 2007;Elesber et al, 2007;Sharkey et al, 2008;Blessing et al, 2007;Sharkey et al, 2007;Fazio et al, 2008). Thus, this pathophysiological mechanism is still debated.…”

Section: Catecholamine Excessmentioning

confidence: 98%

See 1 more Smart Citation

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

Montassier¹,

Segard²,

Martinage³

et al. 2011

Coronary Angiography - The Need for Improvement in Medical and Interventional Therapy

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Section: Populationmentioning

confidence: 96%

Section: Catecholamine Excessmentioning

confidence: 98%

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

Montassier¹,

Segard²,

Martinage³

et al. 2011

Coronary Angiography - The Need for Improvement in Medical and Interventional Therapy

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“…Andere Autoren stehen der Applikation von β-Blockern jedoch kritisch gegenüber [2], da die potenziell unerwünschten Effekte der β-Blockade bei erhöhten Katecholaminspiegeln und nichtblockierten α-Rezeptoren miteinkalkuliert werden müs-sen [2]. In einer retrospektiven Analyse konnte für die Dauertherapie einer TK jedoch weder für Aspirin, ACE-Inhibitoren, Kalziumantagonisten noch für β-Blocker ein positiver Effekt nachgewiesen werden, sodass die Autoren keine Indikation für den Einsatz dieser Medikamente sahen [14]. Der Nachweis eines intrakardialen Thrombus macht eine systemische Antikoagulation mit Phenprocoumon oder Heparinen erforderlich.…”

Section: Verlaufunclassified

Tako-Tsubo-Kardiomyopathie

Roggenbach

Ehlermann

2010

Anaesthesist

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Tako-Tsubo cardiomyopathy (TK) is an acutely appearing myocardial disease leading to impaired cardiac function, which can barely be distinguished clinically from an acute myocardial infarction. It occurs mainly in postmenopausal women and usually has a good prognosis. The pathophysiology of TK still remains to be elucidated but the favoured hypothesis is myocardial damage induced by catecholamine excess. Various acute diseases, emotional stress, surgical procedures and anaesthesia have been described as possible causes for TK. Little is known about the optimal therapy, however, there might be potential differences in the therapy of TK compared to contemporary therapy algorithms for heart failure. Knowledge of TK as a differential diagnosis for acute myocardial infarction is necessary to avoid incorrect treatment.

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“…Although they have not shown any long-term benefit when compared to placebo, 30 ethically and physiologically, it seems reasonable to aggressively manage an acute cardiac failure. The aim should be to maintain supportive treatment in order to hopefully reduce cardiovascular morbidity and short-term mortality.…”

Section: Treatment and Follow-upmentioning

confidence: 99%

Transient Cardiac Ballooning—The Syndrome

Gupta

Sech

Lazzara

2009

Clinical Cardiology

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Transient cardiac ballooning is usually a reversible clinical entity. A patient typically presents with chest pain, electrocardiogram (ECG) abnormalities like ST‐segment elevation (most commonly reported) or depression, and elevated cardiac enzymes, but has no or nonobstructive coronary artery disease. Left ventriculography reveals transient akinesis of the involved portion of the myocardial wall with compensatory hyperkinesis of the remaining myocardium, leading to ballooning of the noncontracting myocardial wall during systole. Acute regional myocardial dysfunction ensues, which normalizes on average within 1 to 6 weeks. The hypotheses for these pathophysiologic changes range from direct cardiac myocyte injury to postischemic myocardial stunning to neurotransmitter actions. The objective of this article is to present a succinct description of a small case series accompanied with various recently reported presentations and morphology by left ventriculogram and a detailed review of available data on underlying pathophysiology. In addition, a discussion on current diagnostic guidelines, treatment, prognosis, and potential future investigations is included. Copyright © 2009 Wiley Periodicals, Inc.

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Chronic pharmacological treatment in takotsubo cardiomyopathy

Cited by 46 publications

References 21 publications

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

Tako-Tsubo Cardiomyopathy: A Recent Clinical Syndrome Mimicking an Acute Coronary Syndrome

Tako-Tsubo-Kardiomyopathie

Transient Cardiac Ballooning—The Syndrome

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