Chronic polychlorinated biphenyls exposure on three generations of oldfield mice (Peromyscus polionotus): Effects on reproduction, growth, and body residues

McCoy, George L.; Finlay, Mary-Fleming; Rhone, A.; James, Kaitlin C.; Cobb, George P.

doi:10.1007/bf00211624

Cited by 21 publications

(21 citation statements)

References 10 publications

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“…5, a body weight of 0.22 kg (Table 1) and a food consumption rate of 3.4 glday (Table l), the estimated NOAEL for this species would be 20.155 mgkg bw/day. A dietary LOAEL of 5 ppm was reported for oldfield mice (McCoy et al 1995). Using Eq.…”

Section: Toxicity To Wildlifementioning

confidence: 99%

See 1 more Smart Citation

Toxicological benchmarks for wildlife: 1996 Revision

Sample¹,

Opresko²,

Suter³

1996

128

146

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Section: Toxicity To Wildlifementioning

confidence: 99%

“…Empirical data are available for four species: laboratory rat (Linder et al 1974), white-footed mouse (Linzey 1987), oldfield mouse (McCoy et al 1995) and mink (Aulerich and Ringer 1977). Reproductive and/or developmental changes were the endpoints evaluated in each of these studies.…”

Section: Extrapolations To Wildlife Speciesmentioning

confidence: 99%

Toxicological benchmarks for wildlife: 1996 Revision

Sample¹,

Opresko²,

Suter³

1996

128

146

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“…Phillips and Batty (1995) injected female Mongolian gerbils with a single dose of Aroclor 1254 (2 mg and 4 mg) after mating with untreated males and found no differences in the percentage of successful breeding pairs or litter size. McCoy et al (1995) found that pairs of Oldfield mice (Peromyscus polionotus) consuming diets containing Aroclor had higher fertility rates than their corresponding controls.…”

Section: Discussionmentioning

confidence: 99%

Immunological, Hematological, and Biochemical Responses in Immature White-Footed Mice Following Maternal Aroclor 1254 Exposure: A Possible Bioindicator

Greeley

Hansen

et al. 1999

Arch. Environ. Contam. Toxicol.

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A number of hematological, immunological, and biochemical parameters were measured in Peromyscus leucopus pups born from dams exposed to a single dose (300 mg/kg body weight) of Aroclor 1254. To increase the chances of uncovering even modest consequences of the exposure, in one protocol the pups were weaned at 3 weeks and examined at 6 weeks of age, while in a second protocol the pups were kept with their mother for 4 weeks, at which time they were examined. The older pups showed significant decreases in body weight, ratio of spleen weight to body weight, numbers of peripheral white blood cells and lymphocytes, and number and percentage of monocytes. They also showed significant increases in the stimulation index in response to the mitogen phytohemagglutinin (PHA), percentage of peripheral blood neutrophils and liver EROD induction. Pups sacrificed at 4 weeks of age showed even more significant differences. Their body and liver weights, percentage and number of peripheral blood lymphocytes, and serum antibody titers were significantly lower than those of their controls, while spleen to body weight ratios, percent of neutrophils in their peripheral blood, and liver EROD, PROD, and BROD levels were significantly higher than those of the controls. The primary implication of this work is that white-footed mouse pups could be used as biomonitors of contaminated sites. Females could be captured at the sites and bred in captivity with normal males. The vulnerable parameters identified in this study could then be measured in the resulting offspring and compared with a database collected from normal pups.

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“…The short-tailed shrew NOAEL and LOAEL are based on a study in which oldfield mice were fed Aroclor-1254 for 12 months (McCoy et al 1995). A dose level of 0.68 mg/kg/d, designated as the chronic LOAEL, caused a reduction in the number of litters, offspring weights, and offspring survival.…”

Section: Pcbsmentioning

confidence: 99%

“…Because an experimental NOAEL was not established, the chronic NOAEL was estimated by multiplying the chronic LOAEL by a LOAEL-NOAEL uncertainty factor of 0.1. Based on the results of McCoy et al (1995), short-tailed shrews experiencing exposures z the LOAEL may display impaired reproduction and offspring viability.…”

Section: Pcbsmentioning

confidence: 99%

Preliminary assessment of the ecological risks to wide-ranging wildlife species on the Oak Ridge Reservation

Sample¹,

Baron²,

Jackson³

1995

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DlSTRlBUTlON OF Q S T IThis report has been reproduced directly from the best available copy.Available to DOE DISCLAIMERThis report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government nor any agency thereof, nor any of their employees, make any warranty, express or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein t o any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government or any agency thereof. The views and opinions of authors expressed herein do not necessarily state or reflect those of the United States Government or any agency thereof. DISCLAIMER 2-2 G-40Soil-plant uptake factors fiom collocated soil and plant samples collected G-52Soil-plant organic contaminant uptake factors using octanol water F-18HQs for contaminants of potential concern for white-tailed deer on the ORR ..... ACKNOWLEDGMENTSThis report is the result of the efforts, contributions, and support of many persons. We are grateful to Sigurd Christensen, Craig Brandt, Michelle Bell, and John Fackenthal for their work in identi%@, locating, and acquiring data for use in this assessment. We also thank all of the ER personnel who responded to requests for data and provided input and support. We thank the following for providing us with their data and aiding in it's interpretation: George Southworth, Mark Peterson, Walter Hill, Rich Stevens, Chuck Hadden, Pat Ryon, Christy Anderson, Robert Brewer, Dick Halbrook, Chris Welsh, and Jim Evans. Brent Ziegler and John Paul Van Stone provided technical support. All maps were produced by Robert Washington-Allen. Finally, this report has benefitted from the reviews of Glenn Suter and Tom Ashwood. xv i EXECUTIVE SUMMARYHistorically, ecological risk assessment at CERCLA sites [such as the Oak Ridge Reservation (OW)], has focused on species that may be definitively associated with a Contaminated area or source operable unit. This is necessary to identify areas where risk is sufficiently high to warrant remediation. Consequently the species that are generally considered are those with home ranges small enough such that multiple individuals or a distinct population can be expected to reside within the boundaries of the contaminated site. This approach is adequate for sites with single, discrete areas of contamination that only provide habitat for species with limited spatial (e.g., small home range) requirements. This approach is not adequate however for large sites with multiple, spatially separated contaminated areas that provide habitat for wide-ranging wildlife species. Because wide-ranging wildlife species may travel between and use multiple contaminate...

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Chronic polychlorinated biphenyls exposure on three generations of oldfield mice (Peromyscus polionotus): Effects on reproduction, growth, and body residues

Cited by 21 publications

References 10 publications

Toxicological benchmarks for wildlife: 1996 Revision

Toxicological benchmarks for wildlife: 1996 Revision

Immunological, Hematological, and Biochemical Responses in Immature White-Footed Mice Following Maternal Aroclor 1254 Exposure: A Possible Bioindicator

Preliminary assessment of the ecological risks to wide-ranging wildlife species on the Oak Ridge Reservation

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