Chronic Post-mastectomy Pain: Clinical Aspects

Lakdja, F.; Rascle, Nicole; Labrèze, Laurent; Dixmerias, F.; Lakdja, P.-O.; Barrault, M.

doi:10.1007/978-3-319-04322-7_13

Cited by 4 publications

(5 citation statements)

References 30 publications

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“…Five new studies (n = 451) evaluated nonsteroidal antiinflammatory drugs (NSAID) including one celecoxib, 100 one dexketoprofen, 101 one flurbiprofen axetil, 102 one parecoxib, 103 and one IV parecoxib in combination with oral celecoxib 104 (total, eight studies; n = 1,602). [100][101][102][103][104][105][106][107] Two of eight studies reported prevalence of any pain at 3 months, 103,104 three studies at 6 months, 102,104,106 and four studies at 12 months. [102][103][104]107 Prevalence of any pain at 3 months ranged from 48.8 to 59.1% (mean, 53.9%) in the placebo arm and 22.5 to 54.3% (mean, 38.4%) in the NSAID arm.…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

Carley¹,

Chaparro²,

Choinière³

et al. 2021

Anesthesiology

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Background Chronic postsurgical pain can severely impair patient health and quality of life. This systematic review update evaluated the effectiveness of systemic drugs to prevent chronic postsurgical pain. Methods The authors included double-blind, placebo-controlled, randomized controlled trials including adults that evaluated perioperative systemic drugs. Studies that evaluated same drug(s) administered similarly were pooled. The primary outcome was the proportion reporting any pain at 3 or more months postsurgery. Results The authors identified 70 new studies and 40 from 2013. Most evaluated ketamine, pregabalin, gabapentin, IV lidocaine, nonsteroidal anti-inflammatory drugs, and corticosteroids. Some meta-analyses showed statistically significant—but of unclear clinical relevance—reductions in chronic postsurgical pain prevalence after treatment with pregabalin, IV lidocaine, and nonsteroidal anti-inflammatory drugs. Meta-analyses with more than three studies and more than 500 participants showed no effect of ketamine on prevalence of any pain at 6 months when administered for 24 h or less (risk ratio, 0.62 [95% CI, 0.36 to 1.07]; prevalence, 0 to 88% ketamine; 0 to 94% placebo) or more than 24 h (risk ratio, 0.91 [95% CI, 0.74 to 1.12]; 6 to 71% ketamine; 5 to 78% placebo), no effect of pregabalin on prevalence of any pain at 3 months (risk ratio, 0.88 [95% CI, 0.70 to 1.10]; 4 to 88% pregabalin; 3 to 80% placebo) or 6 months (risk ratio, 0.78 [95% CI, 0.47 to 1.28]; 6 to 68% pregabalin; 4 to 69% placebo) when administered more than 24 h, and an effect of pregabalin on prevalence of moderate/severe pain at 3 months when administered more than 24 h (risk ratio, 0.47 [95% CI, 0.33 to 0.68]; 0 to 20% pregabalin; 4 to 34% placebo). However, the results should be interpreted with caution given small study sizes, variable surgical types, dosages, timing and method of outcome measurements in relation to the acute pain trajectory in question, and preoperative pain status. Conclusions Despite agreement that chronic postsurgical pain is an important topic, extremely little progress has been made since 2013, likely due to study designs being insufficient to address the complexities of this multifactorial problem. Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New

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Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

Carley¹,

Chaparro²,

Choinière³

et al. 2021

Anesthesiology

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“…Considerable efforts have already been made for understanding the electronic band structure of III-V nitride alloys (InGaN, AlGaN, and AlInN) [4][5][6][7][8][9][10][11][12][13] and SLs (InN/GaN and GaN/AlN). [14][15][16][17][18][19][20][21] However, there are few reports in the open literature on the bandgap [22] and on the synthesis [23] of InN/AlN SLs. Because of the discrepancy in growth conditions, lattice constant, and thermal expansion coefficient between InN and AlN, it is well imagined that fabrication of InN/AlN SLs is extremely difficult.…”

Section: Introductionmentioning

confidence: 99%

First‐Principles Calculation of Bandgaps of Al_1−xIn_xN Alloys and Short‐Period Al_1−xIn_xN/Al_1−yIn_yN Superlattices

Kawamura

Fujita

Hamaji

et al. 2019

Physica Status Solidi (b)

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Bandgaps of AlInN alloys, short‐period InN/AlN superlattices (SLs), and short‐period AlInN alloy SLs are calculated using first‐principles calculations with the pseudopotential self‐interaction correction method. The dependence of these bandgaps on the composition and thickness of the SLs and the influence of strain are investigated. It is found that the bandgaps of the InN/AlN SLs depend on both the composition and thickness of the SLs. The maximum value of the bandgap equal to 2.56 eV is obtained for 1InN/4AlN SLs. The bandgaps of AlInN alloy SLs decrease with an increase in In content, and they cover the whole range between the values of AlN and InN. The bandgaps of InN/AlN SLs lattice‐matched to AlN are smaller than those of free‐standing InN/AlN SLs.

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“…Nevertheless, studies examining the long-lasting effects of perioperative NSAID administration could not demonstrate a positive effect on persistent postoperative pain. [60][61][62][63] In a recent meta-analysis and systematic review, the effects of various perioperative pharmacologic strategies to prevent chronic pain after surgery were assessed. The included studies differed in type of NSAID, duration of administration, type of surgery, but also outcome measures such as reported time endpoints to score the prevalence of pain ranged from 3 to 12 months.…”

Section: Nsaids In Preventing Chronic Pain After Surgerymentioning

confidence: 99%

Immune Modulatory Effects of Nonsteroidal Anti-inflammatory Drugs in the Perioperative Period and Their Consequence on Postoperative Outcome

et al. 2022

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Nonsteroidal anti-inflammatory drugs are among the most commonly administered drugs in the perioperative period due to their prominent role in pain management. However, they potentially have perioperative consequences due to immune-modulating effects through the inhibition of prostanoid synthesis, thereby affecting the levels of various cytokines. These effects may have a direct impact on the postoperative outcome of patients since the immune system aims to restore homeostasis and plays an indispensable role in regeneration and repair. By affecting the immune response, consequences can be expected on various organ systems. This narrative review aims to highlight these potential immune system–related consequences, which include systemic inflammatory response syndrome, acute respiratory distress syndrome, immediate and persistent postoperative pain, effects on oncological and neurologic outcome, and wound, anastomotic, and bone healing.

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Chronic Post-mastectomy Pain: Clinical Aspects

Cited by 4 publications

References 30 publications

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

First‐Principles Calculation of Bandgaps of Al_1−xIn_xN Alloys and Short‐Period Al_1−xIn_xN/Al_1−yIn_yN Superlattices

Immune Modulatory Effects of Nonsteroidal Anti-inflammatory Drugs in the Perioperative Period and Their Consequence on Postoperative Outcome

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Chronic Post-mastectomy Pain: Clinical Aspects

Cited by 4 publications

References 30 publications

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis

First‐Principles Calculation of Bandgaps of Al1−xInxN Alloys and Short‐Period Al1−xInxN/Al1−yInyN Superlattices

Immune Modulatory Effects of Nonsteroidal Anti-inflammatory Drugs in the Perioperative Period and Their Consequence on Postoperative Outcome

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Product

Resources

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First‐Principles Calculation of Bandgaps of Al_1−xIn_xN Alloys and Short‐Period Al_1−xIn_xN/Al_1−yIn_yN Superlattices