Chronic post-traumatic headache after mild head injury: A descriptive study

Kjeldgaard, D; Forchhammer, Hysse Birgitte; Teasdale, Thomas W.; Jensen, Rigmor

doi:10.1177/0333102413505236

Cited by 60 publications

(71 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several more recent reports on Post‐Traumatic Headache have noted migraine or probable migraine phenotype in up to 75% of TBIS . On the contrary, a recent study from Denmark dealing with 90 Post‐Traumatic Headache patients with mild TBI selected from a headache clinic population, employed a nonhierarchical classification and found tension type headache in 97%, migraine in 26% and multiple headache types in 36% . Comparability to the present study is not clear.…”

Section: Discussioncontrasting

confidence: 93%

Headache Prevalence at 4–11 Years After Deployment‐Related Traumatic Brain Injury in Veterans of Iraq and Afghanistan Wars and Comparison to Controls: A Matched Case‐Controlled Study

Couch

Stewart

2016

Headache

View full text Add to dashboard Cite

At 4-11 years after D-TBI for TBIS, or after deployment for CS, the TBIS as compared to CS suffered much more frequent and severe headaches. For TBIS, there was no relation of headache intensity or phenotype to severity or cause of the TBI, and the Headache Burden has not improved over time up to 11 years after D-TBI. The process initiated by the D-TBI that relates to the headache has a prolonged effect up to and beyond 11 years.

show abstract

Section: Discussioncontrasting

confidence: 93%

Headache Prevalence at 4–11 Years After Deployment‐Related Traumatic Brain Injury in Veterans of Iraq and Afghanistan Wars and Comparison to Controls: A Matched Case‐Controlled Study

Couch

Stewart

2016

Headache

View full text Add to dashboard Cite

show abstract

“…12 Derek Denny-Brown described PTH in 200 consecutive head injury patients at Boston City Hospital in 1944. 7,8,[14][15][16][17][18] Some studies excluded subjects with mixed headaches. They were variable in severity and described as steady, throbbing, aching, dull, burning, or pressing.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies 8,17,18,21 commented that onset between a week and a month was not rare. The ICHD-2 requires that the onset of headache should be less than a week after the head injury.…”

Section: Introductionmentioning

confidence: 99%

Posttraumatic Headache: Classification by Symptom‐Based Clinical Profiles

Lucas

Ahn

2018

Headache

View full text Add to dashboard Cite

There are currently no accepted therapies for posttraumatic headache (PTH). In order to meet the urgent need for effective therapies for PTH, we must continue to address fundamental gaps in our understanding of the clinical course and impact of PTH. Here we examine the existing schema used to characterize the clinical characteristics of PTH, including the International Classification of Headache Disorders (ICHD). There remain unresolved questions about whether to classify patients based on the extent of brain injury or on clinical symptom profiles. There also remain problematic issues of definition such as continuous headache, and chronic daily headache with features of "embedded" migraine-type within these headaches, which will need to be studied further. We make the case that a symptom-based classification is needed to begin an examination of these unresolved questions, and to establish clinically relevant endpoints for research and clinical trials for effective therapies.

show abstract

“…10,11 Studies on the characteristics and pathophysiology of CPTHA are surprisingly scarce. Consequently, the mechanism of CPTHA, and hence its treatment, remains as yet unclear.…”

mentioning

confidence: 99%

Deficient Pain Modulatory Systems in Patients with Mild Traumatic Brain and Chronic Post-Traumatic Headache: Implications for its Mechanism

Defrin

Riabinin

Feingold

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

Although the prevalence rate of chronic post-traumatic headache (CPTHA) after mild traumatic brain injury (TBI) reaches up to 95%, its mechanism is unknown, and little is known about the characteristics of the pain system in this condition. Our aim was to investigate the capabilities of two pain modulatory systems among individuals with CPTHA and study their association with CPTHA, here for the first time. Forty-six subjects participated; 16 with TBI and CPTHA, 12 with TBI without CPTHA, and 18 healthy controls. Testing included the measurement of heat-pain (HPT) and pressure-pain (PPT) thresholds in the forehead and forearm, pain adaptation to tonic noxious heat, and conditioned pain modulation (CPM).The participants completed a post-traumatic stress disorder (PTSD) questionnaire. The two TBI groups did not differ in the TBI and background characteristics. However, TBI patients with CPTHA had significantly higher HPT and lower PPT in the cranium and higher PTSD symptomatology than TBI patients without CPTHA and healthy controls. Adaptation to pain and CPM were diminished in the CPTHA group compared with the two control groups. The intensity of CPTHA correlated negatively with cranial PPT, magnitude of pain adaptation, and CPM. CPTHA intensity correlated positively with PTSD symptomatology. CPTHA appears to be characterized by cranial hyperalgesia and dysfunctional pain modulation capabilities, which are associated with CPTHA magnitude. It is concluded that damage to pain modulatory systems along with chronic cranial sensitization underlies the development of CPTHA. PTSD may reinforce CPTHA and vice versa. Clinical implications are discussed.

show abstract

Chronic post-traumatic headache after mild head injury: A descriptive study

Abstract: The loss of work capacity and high levels of disability for the CPTH patients suggests directions for further research into what important factors are embedded in the patients' PTSD symptoms and might explain their prolonged illness.

Cited by 60 publications

References 31 publications

Headache Prevalence at 4–11 Years After Deployment‐Related Traumatic Brain Injury in Veterans of Iraq and Afghanistan Wars and Comparison to Controls: A Matched Case‐Controlled Study

Headache Prevalence at 4–11 Years After Deployment‐Related Traumatic Brain Injury in Veterans of Iraq and Afghanistan Wars and Comparison to Controls: A Matched Case‐Controlled Study

Posttraumatic Headache: Classification by Symptom‐Based Clinical Profiles

Deficient Pain Modulatory Systems in Patients with Mild Traumatic Brain and Chronic Post-Traumatic Headache: Implications for its Mechanism

Contact Info

Product

Resources

About