Chronic prostatitis (chronic pelvic pain syndrome)

Network pharmacology and in vivo experiment-based strategy for investigating the mechanism of chronic prostatitis/chronic pelvic pain syndrome in QianLieJinDan tablets

“…Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urinary system disease that is prone to recurrence. The main clinical symptoms of CP/CPPS are pelvic pain and discomfort (including in pelvic areas such as the perineum, suprapubic area, inguinal area, testicles or penis), varying degrees of urination, and sexual dysfunction; in some patients, there is even a tendency toward anxiety and depression, which seriously affects quality of life and physical and psychological well-being [ 1 , 2 ]. Epidemiologic surveys have shown that the symptomatic prevalence of CP/CPPS in China is 8.4 % [ 3 ].…”

“…Epidemiologic surveys have shown that the symptomatic prevalence of CP/CPPS in China is 8.4 % [ 3 ]. Moreover, a study across several countries, including North America, Finland, and Singapore, has shown that the prevalence of CP/CPPS in men is 2%–10 % [ 2 ]. A study showed that, due to the increase in life pressure and the influence of living habits, the CP/CPPS patient population tends to become younger, with 78.2 % of patients under the age of 40, exhibiting recurring pathological characteristics, and the prevalence of CP/CPPS increasing with age [ 3 , 4 ].…”

“…Existing studies suggest that the pathogenesis of CP/CPPS may be related to factors such as inflammation, autoimmunity, pathogen infection, urinary reflux, and neuropsychiatric factors [ 2 , 5 , 7 ]. Due to the lack of in-depth and accurate understanding of the triggering factors of CP/CPPS, the pathogenesis of CP/CPPS cannot be summarized as a single factor at this stage [ 8 ].…”

Sertraline Alleviates Chronic Prostatitis by Regulating the TRPV1 Channel

“… 2 The etiological mechanism of CP is complex and has not yet been fully clarified, which may be related to infection, urine regurgitation, psychopsychological factors, neuroendocrine factors, pelvic floor muscle dysfunction, and immune dysfunction. 1 , 3 To date, there is still a lack of effective strategies for the management of CP. 4 , 5 …”