Chronic Prostatitis/Chronic Pelvic Pain Syndrome Leads to Impaired Semen Parameters, Increased Sperm DNA Fragmentation and Unfavorable Changes of Sperm Protamine mRNA Ratio

Berg, Elena; Houska, Petr; Nesheim, Nils; Schuppe, Hans‐Christian; Pilatz, Adrian; Fijak, Monika; Manthey, Marc; Steger, Klaus; Wagenlehner, Florian M. E.; Schagdarsurengin, Undraga

doi:10.3390/ijms22157854

Cited by 19 publications

(7 citation statements)

References 60 publications

(85 reference statements)

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“…22 Oxidative stress has been linked to impaired sperm motility and increased DNA fragmentation in sperm, potentially causing male infertility. 23,24 Apart from bacterial infections, cigarette smoking is a signi cant source of ROS production, which damages various immunological functions. 25 In turn, prostatic in ammation exacerbates the production of ROS.…”

Section: Discussionmentioning

confidence: 99%

A causal relationship between smoking and risk of prostatitis: A two-sample Mendelian randomization analysis

Xiao,

Ding,

Zhou

et al. 2023

Preprint

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Although observational studies have identified an association between smoking and prostatitis, the causal relationship between the two factors remains uncertain. To clarify this association, we used the Two-sample Mendelian randomization (TSMR) method. We obtained exposure and outcome data from publicly available databases. To assess the association between smoking and the risk of prostatitis, we employed multiple statistical approaches, including inverse-variance weighted (IVW), weighted median, weighted mode, MR-Egger, and sample mode. To minimize bias, we conducted Cochran's Q test, generated a funnel plot, utilized MR-Egger analysis, employed the Leave-one-out method, and performed the MR pleiotropy residual sum and outlier test. Based on our TSMR analysis, we found a significant positive correlation between smoking and the risk of prostatitis (OR = 2.26, p-value = 0.019). Furthermore, we observed no heterogeneity in the study as indicated by the Cochran Q-test (p = 0.533 for MR-Egger; p = 0.650 for IVW). Additionally, there was no conclusive evidence of horizontal pleiotropy. Overall, our TSMR analysis provides strong supportive evidence for a causal relationship between smoking and an increased risk of prostatitis. Quitting smoking may reduce the damage caused by smoking to the prostate. This study provides a new mindset for the management of prostatitis.

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Section: Discussionmentioning

confidence: 99%

A causal relationship between smoking and risk of prostatitis: A two-sample Mendelian randomization analysis

Xiao,

Ding,

Zhou

et al. 2023

Preprint

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“…In contrast to acute cases, chronic prostatitis occurred more frequently, accounting for 53% of sperms with increasing motility and 37% with immotility. Berg et al (15) reported that both chronic and acute prostatitis were seen to increase in prevalence with age by more than 40 years and to be associated with increased sperm DNA damage, changes in sperm motility, and abnormalities that have an impact on fertility. Asthenozoospermia and oligospermia were important causes of male infertility for 284 contributing patients, according to the findings by Golshani et al (16) , from which oligozoospermia 45 (15.85%), asthenozoospermia 51 (17.96%), and teratozoospermia 15 (5.28%) were significant causes.…”

Section: Discussionmentioning

confidence: 99%

The Impact of IL-35, Bacterial Prostatitis in Development Male Infertility in Najaf Province Patients

ALhadrawi¹,

ALGarawy²,

Darweesh³

2022

The Egyptian Journal of Hospital Medicine

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Background: A case-control study examined the relationship between bacterial prostatitis and IL-35 blood levels in the emergence of male infertility. Objective: This study aimed to assess the role that bacterial prostatitis and IL-35 play in the progression of male infertility in patients from Najaf province. Patients and Procedures: 120 patients were seen at AL-Sadder Medical City, Al-Najaf province through the period from January to June, 2021. This number included sixty prostatitis-related infertile patients, 30 prostatitis-related fertile patients, and 30 infertile patients. 30 healthy fertile male subjects served as control group. All subjects provided blood and semen samples and three ml of the blood were placed in a gel tube to separate the serum used to calculate IL-35 level by ELISA. A loop of semen was collected to identify the bacterial culprits as well as semen liquefaction, volume, appearance, and fundamental sperm characteristics in the residual semen (density, motility, viability, and morphology). Results: Prostatitis patients had considerably lower serum concentrations of IL-35 than infertile patients did, according to the findings (P< 0.05). The concentration of IL-35, which is thought of as a biomarker for a progressive state, decreased with the severity of the disease. The findings showed that S. aureus and E. coli were the most frequent bacterial causes of prostatitis. Conclusion:The current study found a correlation between infertility and the infection with prostatitis condition, which is reflected in the body's immune response as a lower level of IL-35.

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“…A systematic review and meta-analysis conducted in 2017 by Condorelli et al including 27 studies with a total of 3241 participants found that CP/CPPS was associated with standard parameters of semen analysis, such as reduction in semen volume, sperm concentration, progressive motility and normal morphology [ 50 ]. Furthermore, CP/CPPS has been associated with an increased risk of antisperm antibodies (ASAs) in semen [ 50 ] and functional parameters of sperm, such as higher levels of DNA fragmentation and changes in protamine mRNA ratio compared to healthy individuals [ 51 ].…”

Section: Relation Between Cp/cpps and Male Factor Infertilitymentioning

confidence: 99%

Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility

Graziani,

Grande,

Martin

et al. 2023

Life

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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is defined as urologic pain or discomfort in the pelvic region, associated with urinary symptoms and/or sexual dysfunction, lasting for at least 3 of the previous 6 months. The rate of symptoms related to prostatitis has a mean prevalence of 8–8.2%. CP/CPPS is most frequent in men younger than 50 years, among whom it is the most common urologic diagnosis. In the last decades, many studies have been published on CP/CPPS and its association with male infertility. The pathophysiologic relation between CP/CPPS and male infertility involves several aspects, which are not well studied yet. A reduction in semen parameters has been demonstrated in patients with CP/CPPS, and several mechanisms have been proposed to represent putative pathophysiological links between CP/CPPS and infertility, including male accessory gland inflammation, metabolic syndrome, inflammatory bowel disease, HPV co-infection and autoimmunity. In light of this evidence, a multidisciplinary approach is advocated for patients with known CP/CPPS, and particular attention is needed for male patients of infertile couples in order to evaluate male accessory glands correctly. In addition, it is advisable that future studies dealing with the treatment of CP/CPPS take into consideration all the different pathophysiological aspects implicated.

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Chronic Prostatitis/Chronic Pelvic Pain Syndrome Leads to Impaired Semen Parameters, Increased Sperm DNA Fragmentation and Unfavorable Changes of Sperm Protamine mRNA Ratio

Cited by 19 publications

References 60 publications

A causal relationship between smoking and risk of prostatitis: A two-sample Mendelian randomization analysis

A causal relationship between smoking and risk of prostatitis: A two-sample Mendelian randomization analysis

The Impact of IL-35, Bacterial Prostatitis in Development Male Infertility in Najaf Province Patients

Chronic Prostatitis/Chronic Pain Pelvic Syndrome and Male Infertility

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