Chronic Psychological Stress Disrupts Iron Metabolism and Enhances Hepatic Mitochondrial Function in Mice

Guo, Songjun; Dong, Yingying; Cheng, Xiaoxian; Chen, Zijin; Ni, Yingdong; Zhao, Ruqian; Ma, Wenqiang

doi:10.1007/s12011-022-03269-5

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…Iron overload may also function in fear memory and in the pathology of PTSD. In peripheral tissues, chronic psychological stress in mice led to significantly increased iron content in plasma and the duodenum, whereas the hepatic iron level was markedly de-creased, providing insights into the mechanisms of iron metabolism during the stress disorder [128]. In a rat model of PTSD, stress exposure increased the level of total brain iron, and TfR1 and ferritin expression in the hippocampus, frontal cortex, and striatum, all of which are associated with fear memory treatment.…”

Section: Iron Overload In the Pathology Of Ptsd And Fear Memorymentioning

confidence: 99%

Brain Iron Homeostasis and Mental Disorders

Wu,

Ren,

Meng

et al. 2023

Antioxidants

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Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders.

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Section: Iron Overload In the Pathology Of Ptsd And Fear Memorymentioning

confidence: 99%

Brain Iron Homeostasis and Mental Disorders

Wu,

Ren,

Meng

et al. 2023

Antioxidants

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“…A human study also showed that prenatal stress can affect placental mitochondrial DNA gene expression, and increased expression of MT-ND2 was subsequently linked to infant temperament [138]. Furthermore, a recent study in mice found that chronic social stress can disrupt iron metabolism and enhance hepatic mitochondrial function and ATP production [139].…”

Section: Other Mechanismsmentioning

confidence: 99%

The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes

Reid,

Georgieff

2023

Nutrients

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This review presents evidence from animal and human studies demonstrating the possible connection and significant impact of poor iron status and psychological distress on neurocognitive development during pregnancy and the neonatal period, with implications for long-term cognition. Stress and iron deficiency are independently prevalent and thus are frequently comorbid. While iron deficiency and early-life stress independently contribute to long-term neurodevelopmental alterations, their combined effects remain underexplored. Psychological stress responses may engage similar pathways as infectious stress, which alters fundamental iron metabolism processes and cause functional tissue-level iron deficiency. Psychological stress, analogous to but to a lesser degree than infectious stress, activates the hypothalamic–pituitary–adrenocortical (HPA) axis and increases proinflammatory cytokines. Chronic or severe stress is associated with dysregulated HPA axis functioning and a proinflammatory state. This dysregulation may disrupt iron absorption and utilization, likely mediated by the IL-6 activation of hepcidin, a molecule that impedes iron absorption and redistributes total body iron. This narrative review highlights suggestive studies investigating the relationship between psychological stress and iron status and outlines hypothesized mechanistic pathways connecting psychological stress exposure and iron metabolism. We examine findings regarding the overlapping impacts of early stress exposure to iron deficiency and children’s neurocognitive development. We propose that studying the influence of psychological stress on iron metabolism is crucial for comprehending neurocognitive development in children exposed to prenatal and early postnatal stressors and for children at risk of early iron insufficiency. We recommend future directions for dual-exposure studies exploring iron as a potential mediating pathway between early stress and offspring neurodevelopment, offering opportunities for targeted interventions.

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“…The degree of physiological stress-induced injury was evaluated by indicators that would reflect the structures and functions of the heart [ 5 ], and body weight. An open field experiment was used as the gold standard for evaluating whether the psychological stress model was successfully established [ 6 , 7 , 8 ], so as to clarify the successful construction of the stress model at the physiological and psychological levels, and to lay a groundwork for the research on the mechanism of heat stress.…”

Section: Introductionmentioning

confidence: 99%

Physiological and Psychological Stress of Microwave Radiation-Induced Cardiac Injury in Rats

Yin

et al. 2023

IJMS

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Electromagnetic waves are widely used in both military and civilian fields, which could cause long-term and high-power exposure to certain populations and may pose a health hazard. The aim of this study was to simulate the long-term and high-power working environment of workers using special electromagnetic radiation occupations to clarify the radiation-induced stress response and cardiac damage and thus gain insights into the mechanisms of injuries caused by electromagnetic radiation. In this study, the combination of microwave and stress was an innovative point, aiming to broaden the research direction with regard to the effect and mechanism of cardiac injury caused by radiation. The myocardial structure was observed by optical and transmission electron microscope, mitochondrial function was detected by flow cytometry, oxidative-stress markers were detected by microplate reader, serum stress hormone was detected by radioimmunoassay, and heart rate variability (HRV) was analyzed by multichannel-physiological recorder. The rats were weighed and subjected to an open field experiment. Western blot (WB) and immunofluorescence (IF) were used to detect the expressions and distributions of JNK (c-Jun N-terminal kinase), p-JNK (phosphorylated c-Jun N-terminal kinase), HSF1 (heat shock factor), and NFATc4 (nuclear factor of activated T-cell 4). This study found that radiation could lead to the disorganization, fragmentation, and dissolution of myocardial fibers, severe mitochondrial cavitation, mitochondrial dysfunction, oxidative-stress injury in myocardium, increase to stress hormone in serum, significant changes in HRV, and a slow gain in weight. The open field experiment indicated that the rats experienced anxiety and depression and had decreased exercise capacity after radiation. The expressions of JNK, p-JNK, HSF1, and NFATc4 in myocardial tissue were all increased. The above results suggested that 30 mW/cm2 of S-band microwave radiation for 35 min could cause both physiological and psychological stress damage in rats; the damage was related to the activation of the JNK pathway, which provided new ideas for research on protection from radiation.

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Chronic Psychological Stress Disrupts Iron Metabolism and Enhances Hepatic Mitochondrial Function in Mice

Cited by 6 publications

References 42 publications

Brain Iron Homeostasis and Mental Disorders

Brain Iron Homeostasis and Mental Disorders

The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes

Physiological and Psychological Stress of Microwave Radiation-Induced Cardiac Injury in Rats

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