Chronic Psychophysiological Insomnia: Hyperarousal and/or Inhibition Deficits? An ERPs Investigation

Bastien, Célyne; St-Jean, Geneviève; Morin, Charles M.; Turcotte, Isabelle; Carrier, Julie

doi:10.1093/sleep/31.6.887

Cited by 111 publications

(94 citation statements)

References 35 publications

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“…The first 10 time points of the functional images were discarded due to the possible instability of the initial MRI signal and the participants' adaptation to the scanning environment. On the basis of MATLAB2010a (Mathworks, Natick, MA, USA), the rest of the data pre-processing was performed by DPARSFA (http://rfmri.org/DPARSF) software, including Digital Imaging and Communications in Medicine (DICOM) standards for form transformation, slice timing, head motion correction, spatial normalization, smooth with a Gaussian kernel of 6×6×6 mm 3 full-width at half-maximum. The participants who had more than 1.5 mm maximum translation in x, y, or z and 1.5° degree of motion rotation were rejected.…”

Section: Discussionmentioning

confidence: 99%

“…A corrected significance level of individual voxel p < 0.01 and the contiguous cluster volume ≥ 1080 mm 3 , using an AlphaSim corrected threshold of cluster p < 0.05, were used to determine the statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Occasional episodes of insomnia symptoms are reported in half of all adults, while chronic insomnia is prevalent in 10-15% of the adult population. 4 In spite of a recent increase in neuroimaging research into PCPIs, it has not gleaned a consistent conclusion about its neuropathology after reviewing the neuroimaging studies of primary insomnia, especially with regard to the structural studies of brain alterations.…”

Section: Introductionmentioning

confidence: 99%

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Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Dai

Nie

Liu

et al. 2016

Journal of Clinical Sleep Medicine

115

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Study Objectives: To explore the regional brain activities in patients with chronic primary insomnia (PCPIs) and their sex differences. Methods: Forty-two PCPIs (27 females, 15 males) and 42 good sleepers (GSs; 24 females, 18 males) were recruited. Six PCPIs (3 males, 3 females) were scanned twice by MRI to examine the test-retest reliability. Amplitude of low frequency fluctuation (ALFF) method was used to assess the local brain features. The mean signal values of the different ALFF areas were analyzed with a receiver operating characteristic (ROC) curve. Simple linear regression analysis was performed to investigate the relationships between clinical features and different brain areas. Results: Both female and male PCPIs showed higher ALFF in the temporal lobe and occipital lobe, especially in female PCPIs. Female PCPIs had lower ALFF in the bilateral cerebellum posterior lobe, left dorsolateral prefrontal cortex, and bilateral limbic lobe; however, male PCPIs showed lower ALFF in the left occipital gyrus. The mean signal value of the cerebellum in female PCPIs showed negative correlations with negative emotions. Compared with male PCPIs, female PCPIs showed higher ALFF in the bilateral middle temporal gyrus and lower ALFF in the left limbic lobe. The different areas showed high testretest stability (Clusters of contiguous volumes ≥ 1080 mm 3 with an intraclass correlation coefficient ≥ 0.80) and high degree of sensitivity and specificity. Conclusions: Female PCPIs showed more regional brain differences with higher and lower ALFF responses than male PCPIs. However, they shared analogous excessive hyperarousal mechanism and wide variations in aberrant brain areas. I NTRO DUCTI O NPatients with chronic primary insomnia (PCPIs), who underwent the subjective experience of chronically disturbed sleep, sleep loss, non-refreshing sleep, and heightened arousal in bed with impaired quality of life, showed a decreased ability to disengage from external information processing at sleep onset.1-3 Occasional episodes of insomnia symptoms are reported in half of all adults, while chronic insomnia is prevalent in 10-15% of the adult population. 4 In spite of a recent increase in neuroimaging research into PCPIs, it has not gleaned a consistent conclusion about its neuropathology after reviewing the neuroimaging studies of primary insomnia, especially with regard to the structural studies of brain alterations. 5 The results of structural studies are either contradictory or required replication. Altena et al. found that PCPIs had a smaller volume of reduced gray matter in the precuneus and left orbitofrontal cortex which strongly correlated with the subjective severity of insomnia, but increased gray matter volume was not found. 6 Joo et al. demonstrated significantly reduced gray matter concentrations in the dorsolateral prefrontal and pericentral cortices, superior temporal gyrus, and cerebellum, and decreased gray matter volumes in the medial frontal lobe and middle temporal lobe in PCPIs compared with good sleepers (GSs), ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Dai

Nie

Liu

et al. 2016

Journal of Clinical Sleep Medicine

115

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show abstract

“…Loewy and Bootzin (1998) and Loewy et al (1999) also recorded a larger N1 and a smaller P2 in insomniacs relative to good sleepers during wakefulness. Bastien et al (2008b) compared primary chronic psychophysiological insomniacs and good sleepers on N1, P2 and N350 components in a multi-assessment protocol. They reported hyperarousal upon awakening in the morning (greater N1 amplitude) in psychophysiological insomniacs compared to good sleepers.…”

Section: Event-related Potentials (Erps)mentioning

confidence: 99%

Insomnia: Neurophysiological and NeuropsychologicalApproaches

Bastien

2011

Neuropsychol Rev

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Insomnia is a symptom, a syndrome and a comorbid disorder. Its diagnosis relies on subjective reports from the afflicted individual and is defined as difficulties in initiating sleep, maintaining sleep, waking up too early or non-restorative sleep. However, insomnia and especially, primary insomnia, has received much attention in insomnia research with the use of objective measures. Insomnia, its peculiarities, most frequent subtypes and two most prominent models will first be briefly introduced. Then, insomnia will be reviewed according to results obtained with the use of neurophysiological measures as basic/traditional as polysomnography to more sophisticated ones such as power spectral analysis, neuroimaging, cyclic alternating patterns and event-related potentials. In addition, a review of the discrepancies between subjective and objective reports of cognitive alterations through neuropsychological testing is offered. The need to combine measures is then highlighted in conclusion.

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“…Nonetheless, the underlying cortical mechanisms associated with chronic insomnia are just beginning to be better understood. [16][17][18][19][20][21][22]. Subjects with psychophysiological (Psy-I) and Para-I differ greatly regarding both objective and subjective sleep variables [23].…”

mentioning

confidence: 99%

Perception of sound stimuli during sleep in patients with paradoxical insomnia

Mf¹,

Lbc²,

Lb³

et al. 2018

Neurol Disord Therap

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Chronic Psychophysiological Insomnia: Hyperarousal and/or Inhibition Deficits? An ERPs Investigation

Cited by 111 publications

References 35 publications

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Gender Differences in Regional Brain Activity in Patients with Chronic Primary Insomnia: Evidence from a Resting-State fMRI Study

Insomnia: Neurophysiological and NeuropsychologicalApproaches

Perception of sound stimuli during sleep in patients with paradoxical insomnia

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