Chronic Pulmonary Melioidosis Masquerading as lung malignancy diagnosed by EBUS guided sheath technique

Zaw, Kyi Kyi; Wasgewatta, Sanjiwika; Kwong, Kin Keung; Fielding, David; Heraganahally, Subash S.; Currie, Bart J.

doi:10.1016/j.rmcr.2019.100894

Cited by 8 publications

(10 citation statements)

References 10 publications

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“…When the disease involves deeper tissues such as mediastinum and intra‐abdominal organs, it is a real challenge for the clinician to obtain clinical samples. Endobronchial ultrasound (EBUS) is a very good tool in locating and sampling the mediastinal lesions [4]. We report a series of three cases where EBUS‐guided fine needle aspiration (FNA) lead to right diagnosis at the earliest and thereby right treatment of melioidosis.…”

Section: Introductionmentioning

confidence: 99%

Melioidosis—role of endobronchial ultrasound

Subramanian

Jaganathan

Hari

et al. 2020

Respirology Case Reports

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Melioidosis is a Gram‐negative bacterial disease caused by Burkholderia pseudomallei. It has got an increasing prevalence in India, although it is not endemic in the country. Rarely, this disease may pose a diagnostic dilemma, because of its similarities with tuberculosis in clinical, radiological, and pathological features. Mediastinal lymphadenopathy as a presentation is rare in melioidosis. Endobronchial ultrasound (EBUS) could be a useful technique in obtaining samples from necrotic mediastinal lesions. We report three cases of mediastinal melioidosis where EBUS‐guided fine needle aspiration (FNA) aided in early diagnosis.

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Section: Introductionmentioning

confidence: 99%

Melioidosis—role of endobronchial ultrasound

Subramanian

Jaganathan

Hari

et al. 2020

Respirology Case Reports

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“…Zaw et al [ 9 ] described a case of melioidosis mimicking lung malignancy. Initial imaging of the chest by CT showed a right lower lobe opacity suspicious for primary pulmonary malignancy, and PET scan showed moderate FDG avidity of the lesion.…”

Section: Discussionmentioning

confidence: 99%

18-Fluorine-fluorodeoxyglucose positron emission Tomography–Computed tomography in the evaluation of the great masquerader melioidosis: A case series

et al. 2020

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Melioidosis is an emerging infectious disease in India. The disease has a crippling effect on the patient owing to its widespread dissemination and complications post bacteremia. The role of 18-fluorine-fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET-CT) is becoming increasingly important in terms of documenting the extent of disease and response to treatment. Herein, we present cases of two patients who were referred for a whole-body 18F-FDG PET-CT scan with a history of long-standing fever that went undiagnosed. 18F-FDG PET-CT scan was performed to evaluate pyrexia of unknown origin. A conclusion was reached after blood culture which showed the growth of Burkholderia pseudomallei – which is considered to be the cause of this rare but debilitating disease.

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“…9,10 Occasionally, melioidosis manifests as a mass-like lesion indistinguishable from lung cancer. 11 A simultaneous presentation of lung cancer and chronic infection, especially melioidosis, is rare. Mays et al previously described lung cancer developed after a long latency of chronic cavitary form of pulmonary melioidosis.…”

Section: Dovepressmentioning

confidence: 99%

<p>Non-Small Cell Lung Carcinoma with Concomitant Localized Pulmonary Melioidosis: A Rare Co-Existing Disease</p>

Laplertsakul

Sutherasan

Suwatanapongched

et al. 2020

IDR

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Melioidosis is caused by Burkholderia pseudomallei, water-and-soil gramnegative bacteria predominantly found in Southeast Asia and Australia. Herein, we reported a 63-year-old Thai man presenting with prolonged fever, non-productive cough, and weight loss for 3 months. He underwent deceased donor kidney transplantation 4 years ago and was on many immunosuppressive agents after transplantation. At presentation, his chest radiograph showed a mass-like lesion in the left upper lobe. Histopathological examination of a transthoracic needle lung biopsy yielded adenocarcinoma, while tissue culture grew for B. pseudomallei. He was diagnosed with stage IIIA non-small cell lung cancer (T4N0M0) co-existing with localized pulmonary melioidosis. After intensive and eradication therapy for melioidosis, his well-being improved with the resolution of fever. He sequentially underwent left upper lobectomy, but the procedure was not accomplished due to severe adhesions surrounding the left lung and great vessels. After surgery, he received concurrent chemoradiation therapy for his lung cancer. Nevertheless, the disease progressed, and he finally passed away. Since fever is not a common manifestation of lung cancer, co-existing infection, such as tuberculosis, fungal infection, and melioidosis, should always be excluded in patients suspected of having lung cancer presenting with unexplained fever.

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Chronic Pulmonary Melioidosis Masquerading as lung malignancy diagnosed by EBUS guided sheath technique

Cited by 8 publications

References 10 publications

Melioidosis—role of endobronchial ultrasound

Melioidosis—role of endobronchial ultrasound

18-Fluorine-fluorodeoxyglucose positron emission Tomography–Computed tomography in the evaluation of the great masquerader melioidosis: A case series

<p>Non-Small Cell Lung Carcinoma with Concomitant Localized Pulmonary Melioidosis: A Rare Co-Existing Disease</p>

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