Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report

Leahey, P. Alexander; Tahan, Steven R.; Kasper, Ekkehard M.; Albrecht, Mary

doi:10.1093/ofid/ofv185

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Because C. burnetii vascular infections are latent and initially present with unspecific symptoms (weight loss or unexplained fever in a patient with an aneurysm or vascular graft), in the majority of the reported cases the diagnosis was made when complications occurred. The main complications are aortoduodenal fistulas (555,558,568) leading to catastrophic hemorrhage, spondylodiscitis (417,565,575) often associated with psoas abscesses (418), graft or aneurysm rupture (417), (78) and embolic complications (78,417,557). A single case of coinfection with Yersinia enterocolitica has been reported (411).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Clinical Manifestationsmentioning

confidence: 99%

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…Sixty percent of infections may be chronic and unrecognized [2]. However, Q fever has also co-occurred with severe diseases, including osteomyelitis, hepatic disease, vascular disease, and endocarditis [2][3][4]. In 1988, the first case of an abdominal aortic aneurysm (AAA) associated with polymerase chain reaction (PCR)-proven Q fever was described [5].…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q Fever

Niet

Tielliu

Schaik

et al. 2017

Aorta

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A 70-year-old man was successfully treated for an aortoduodenal fistula originating from a Q fever-related abdominal aortic aneurysm. He had no known history of contact with cattle or sheep. Although the combination of abdominal aortic aneurysm and aortoduodenal fistula is rare, one should be suspicious of Q fever infection as the causative agent, and additional medical treatment should be initiated.

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“…In addition to endocarditis, osteomyelitis is another chronic Q fever complication [16][17][18]. C. burnetii grows on the abnormal cardiac valve along with the prosthetic valve and causes Q fever non-speci c manifestations, therefore chronic Q fever is hardly diagnosed and because of several antimicrobial treatment resistance, it is hardly treated too.…”

Section: Discussionmentioning

confidence: 99%

Recurrent culture-negative endocarditis and osteomyelitis caused by Q fever in Iran, a case report

Moradi

Kanafgorabi

Larti

et al. 2022

Preprint

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Background: Endocarditis is an infection of the endocardial layer of the heart known as fatal infection. Gold standard diagnosis of infectious endocarditis is blood culture, which in some cases can be negative. In blood culture-negative endocarditis, the early diagnosis, and treatment are much harder, which can increase morbidities and also mortality. Case presentation: In this case report we are presenting a patient with intermittent fever for three months with a history of aortic and pulmonary valve replacement and also recurrent blood culture-negative endocarditis. According to the pandemic situation, we checked the Covid-19 PCR and also performed a chest computed tomography (CT) -scan, which both were negative and did not represent any pathologic conditions. Other examinations such as transesophageal echocardiography (TEE) and blood cultures were all normal and the only abnormal finding we had was a positron emission tomography (PET) - CT scan with endocarditis and sternum osteomyelitis evidence. Conclusion: After several evaluations based on endemic epidemiology, the Real-time PCR and IFA (IgG phase I; 1:16384, IgG phase II; 1:16384) were positive for Q fever and the patient responded to the proper doxycycline and hydroxychloroquine treatment.

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Chronic Q-Fever (Coxiella burnetii) Causing Abdominal Aortic Aneurysm and Lumbar Osteomyelitis: A Case Report

Cited by 12 publications

References 9 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

A Case of Primary Aortoduodenal Fistula and Abdominal Aortic Aneurysm in a Patient with Chronic Q Fever

Recurrent culture-negative endocarditis and osteomyelitis caused by Q fever in Iran, a case report

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