Chronic Radiation Enteritis

Jain, Gaurav; Scolapio, James S.; Wasserman, Evan; Floch, Martin H.

doi:10.1097/00004836-200209000-00003

Cited by 17 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cecum, sigmoid, small bowels, and less commonly the transverse colon may fall into the radiation field due to their relative mobility [38]. Radiation injuries usually occur 6-24 months following initiation of therapy but have been described from 2 months to 30 years post therapy [39,40]. Previous history of abdominal surgery, pelvic inflammatory disease, concomitant arteriosclerosis, diabetes, and/or hypertension increases the likelihood of stricture formation following radiation therapy [38].…”

Section: Radiation Stricturementioning

confidence: 99%

Differential Diagnosis of Colonic Strictures: Pictorial Review with Illustrations from Computed Tomography Colonography

et al. 2015

View full text Add to dashboard Cite

Strictures of the colon can lead to significant morbidity requiring surgical management. The etiology of strictures is broad and generally categorized as benign, malignant, or pseudostrictures. Computed tomography (CT) is a crucial imaging modality in the assessment and characterization of colonic pathologies but colonoscopy remains the diagnostic gold standard. However, in the setting of incomplete colonoscopy due to strictures, the imaging features of CT will be relied on. This review will focus on the CT features of different colon pathologies leading to strictures and will be illustrated with images from 10 years of experience with CT colonography at our institutions from 2002-2012 (Hotel Dieu Hospital, Queen's University and Mount Sinai Hospital, University of Toronto).

show abstract

Section: Radiation Stricturementioning

confidence: 99%

Differential Diagnosis of Colonic Strictures: Pictorial Review with Illustrations from Computed Tomography Colonography

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It is usually associated with radiation doses greater than 45 Gy and it appears after a latency of months to years after the initial exposure. 41,42 The underlying pathology is a progressive radiation-induced endarteritis that causes intestinal ischemia. The ischemia may result in fibrosis, stricturing, ulceration, and occasionally fistula formation.…”

Section: Radiotherapy-induced Diarrheamentioning

confidence: 99%

Evaluation and Management of Treatment-Related Diarrhea in Patients with Advanced Cancer: A Review

Cherny

2008

Journal of Pain and Symptom Management

View full text Add to dashboard Cite

Diarrhea is a common and significant problem among patients with advanced cancer. Treatment-induced diarrhea can be severe and be associated with life-threatening dehydration and electrolyte abnormalities. The causes of diarrhea among patients with advanced cancer are diverse and some causes of diarrhea require specific therapies. Thus, careful evaluation of the underlying cause is necessary. Palliative care clinicians, particularly those dealing with patients receiving ongoing disease-modifying therapies, must be familiar with the common causes of diarrhea among cancer patients and the strategies to evaluate and manage these common and distressing symptoms. This article addresses four major issues: 1) a review of the causes of treatment-related diarrhea, focusing on diarrhea caused by chemotherapy, targeted therapies, and radiotherapy; 2) differential diagnosis and an approach to evaluation; 3) general management considerations; and 4) cause-specific issues in management.

show abstract

“… 10 However, the chronic form may present as early as 2 months or as long as 30 years after exposure. 11 , 12 The mechanisms involved in the initiation and progression of radiation-induced intestinal injury remain largely unexplored; however, extensive data suggest that RE may arise as a result of the interaction of chronic inflammation. 13 Moreover, certain mucosal cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α are significantly elevated in RE patients.…”

Section: Introductionmentioning

confidence: 99%

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis

Fan

Wang

et al. 2016

Medicine

View full text Add to dashboard Cite

The implications of low triiodothyronine syndrome (LT3S) in patients with radiation enteritis (RE) have not been properly investigated. As such, we conducted this cohort study to investigate the association between LT3S and RE, to explore the etiology of LT3S in RE, to evaluate the clinical features and clinical outcomes of LT3S patients, and to inspect the correlation of clinical variables and LT3S in RE.This prospective study included 39 RE patients. Medical records and various laboratory parameters (including thyroidal, tumorous, nutritional, and radiotherapy variables) were collected in all participants.Our results showed that the incidence of LT3S was 84.6% in patients with RE. Total protein (71.7 ± 5.7 vs 63.2 ± 9.6 g/L, P = 0.04) and albumin (ALB, 46.0 ± 4.6 vs 38.7 ± 5.3 g/L, P = 0.01) were significantly lower in LT3S group compared with those in euthyroid group. Standard thyroid-stimulating hormone index (−0.89 ± 2.11 vs −2.39 ± 1.33, P = 0.03) and sum activity of deiodinases (19.74 ± 4.19 vs 12.55 ± 4.32 nmol/L, P = 0.01) were significantly lower in LT3S group. Patients with LT3S suffered longer duration of hospitalization (48.25 ± 23.29 days in LT3S vs 26.75 ± 10.56 days in euthyroid, P = 0.036). Low serum ALB (β = 0.694, 95% CI = 0.007–0.190, P = 0.037) was the only significant predictor of LT3S.LT3S was common in RE patients. A hypodeiodination condition and a potential pituitary-thyrotroph dysfunction might play a role in the pathophysiology of LT3S in RE. Worse nutritional status and clinical outcomes were confirmed in RE patients with LT3S. Furthermore, total protein and ALB were observed as protective and differentiating parameters of LT3S in RE. In summary, this was the 1st investigation to evaluate the clinical correlation between RE and LT3S, investigate the prevalence of LT3S in RE, and explore the pathogenesis of LT3S, despite the limitation of a relatively small sample size. These results will hopefully encourage future research to place greater emphasis on early identification of LT3S in RE patients.

show abstract

Chronic Radiation Enteritis

Cited by 17 publications

References 10 publications

Differential Diagnosis of Colonic Strictures: Pictorial Review with Illustrations from Computed Tomography Colonography

Differential Diagnosis of Colonic Strictures: Pictorial Review with Illustrations from Computed Tomography Colonography

Evaluation and Management of Treatment-Related Diarrhea in Patients with Advanced Cancer: A Review

Low Triiodothyronine Syndrome in Patients With Radiation Enteritis

Contact Info

Product

Resources

About