Chronic recurrent multifocal osteomyelitis. A case report.

Murray, Shane; Kehl, Douglas K.

doi:10.2106/00004623-198466070-00022

Cited by 40 publications

(8 citation statements)

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“…These conditions are usually recurrent and may be associated with skin infections. 22,[24][25][26][27][28] Although multifocal lesions were seen in this and other studies, 13,14 the lesions resolved with treatment, and were not recurrent or associated with skin changes. The recommended treatment for subacute osteomyelitis with a lucent lesion or nidus has been curettage, biopsy and culture followed by immobilisation and antibiotics.…”

Section: Discussioncontrasting

confidence: 39%

Primary subacute haematogenous osteomyelitis in children

Rasool

2001

The Journal of Bone and Joint Surgery

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Between 1990 and 1998 we saw 21 children with primary subacute haematogenous osteomyelitis. Pain, swelling and a limp had been present for two to 12 weeks with little functional impairment. Laboratory tests were non-contributory. The lesions were classified radiologically into metaphyseal, diaphyseal, epiphyseal and vertebral. There were 24 sites involved, with most (20) being in the tibia; 17 lesions were in the diaphysis, five in the metaphysis and two in the epiphysis. The diagnosis was confirmed histologically in all cases. Staphylococcus aureus was cultured in six patients. Healing occurred in all patients after treatment with antibiotics for six weeks and radiological improvement was seen after three to six months. Subacute osteomyelitis develops as a result of increased host resistance and decreased bacterial virulence. The radiological features can mimic various benign or malignant bone tumours and non-pyogenic infections. Histological confirmation is necessary to avoid a delay in diagnosis.

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Section: Discussioncontrasting

confidence: 39%

Primary subacute haematogenous osteomyelitis in children

Rasool

2001

The Journal of Bone and Joint Surgery

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show abstract

Section: Discussioncontrasting

confidence: 39%

Primary subacute haematogenous osteomyelitis in children

Rasool

2001

The Journal of Bone and Joint Surgery. British volume

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Between 1990 and 1998 we saw 21 children with primary subacute haematogenous osteomyelitis. Pain, swelling and a limp had been present for two to 12 weeks with little functional impairment. Laboratory tests were non-contributory. The lesions were classified radiologically into metaphyseal, diaphyseal, epiphyseal and vertebral. There were 24 sites involved, with most (20) being in the tibia; 17 lesions were in the diaphysis, five in the metaphysis and two in the epiphysis. The diagnosis was confirmed histologically in all cases. Staphylococcus aureus was cultured in six patients. Healing occurred in all patients after treatment with antibiotics for six weeks and radiological improvement was seen after three to six months.Subacute osteomyelitis develops as a result of increased host resistance and decreased bacterial virulence. The radiological features can mimic various benign or malignant bone tumours and non-pyogenic infections. Histological confirmation is necessary to avoid a delay in diagnosis. J Bone Joint Surg [Br] 2001;83-B:93-8.

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“…Many authors think that CRMO usually has a favorable evolution with no major sequelae (4,5,10,22,27). However, the long-term (i.e., Ͼ5 years) outcome of CRMO has not been extensively investigated.…”

Section: Discussionmentioning

confidence: 99%

Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term

Vittecoq

Said

Michot

et al. 2000

Arthritis & Rheumatism

133

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Objective. To retrospectively assess, with a sufficiently long followup (mean 11.6 years; median 9 years), the long-term outcome of chronic recurrent multifocal osteitis (CRMO), a multifocal, inflammatory bone disease.Methods. Patients included were 8 children/ adolescents and 7 adults with no family history of rheumatic disease who had been diagnosed as having CRMO between 1979 and 1995. Ten patients had undergone at least 1 bone biopsy of the lesions, with histologic examination and multiple cultures. In 1996, in addition to an in-depth interview, 12 patients underwent an extensive physical examination, laboratory evaluation, HLA-A, B, C, and DR typing, bone radiography and scintigraphy, and computed tomography scan of the sternoclavicular and sacroiliac joints.Results. Remission was observed in 3 patients. The other 12 patients developed various associations of vertebral (n ‫؍‬ 10), sacroiliac (n ‫؍‬ 6), anterior thoracic (n ‫؍‬ 7), peripheral articular (n ‫؍‬ 2), enthesopathic (n ‫؍‬ 4), or dermatologic (palmoplantar pustulosis in 3 cases and psoriasis in 2) involvements. Spine involvement was the most common and occurred the earliest (median time to appearance after the onset of osteitis 5.63 years). Clinical sacroiliitis was always unilateral. No patients carried the HLA-B27 haplotype. CRMO responded well to nonsteroidal antiinflammatory drugs. Twelve patients met the European Spondylarthropathy Study Group criteria for spondylarthopathy.

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Chronic recurrent multifocal osteomyelitis. A case report.

Cited by 40 publications

References 0 publications

Primary subacute haematogenous osteomyelitis in children

Primary subacute haematogenous osteomyelitis in children

Primary subacute haematogenous osteomyelitis in children

Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term

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