Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review

Sergi, Consolato; Miller, Elka; Demellawy, Dina El; Fan, Shanhui; Zhang, Mingyong

doi:10.3389/fimmu.2022.959575

Cited by 22 publications

(12 citation statements)

References 81 publications

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“…3) [10]. For the exclusion or detection of a multifocal manifestation, whole-body MRI has largely replaced bone scintigraphy, due to its higher specificity and lack of radiation exposure, especially in children and adolescents [12], and thus represents the method of choice [8,11,12].…”

Section: Discussionmentioning

confidence: 99%

Hyperostosis of the Clavicle as a Cardinal Symptom for Sapho Syndrome – Presentation and Discussion of a Clinical Case

Andresen,

Reinke,

Radmer

2023

Osteologie

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SAPHO syndrome comprises a broad clinical spectrum and is based on inflammatory osteitis with or without association to a dermatological affection. A young man with chronic recurrent osteomyelitis (CRMO) of the right clavicle as a cardinal symptom of SAPHO syndrome is reported on. Whole-body MRI has proven effective for focal detection and assessment of local activity of a possible multifocal manifestation of CRMO. Multiple medication with NSAIDs, a bisphosphonate, vitamin D substitution and antibiosis resulted in extensive remission of symptoms. Biologicals can also be used if there is no effect. The terminology of chronic nonbacterial osteomyelitis (CNO) in connection with the SAPHO syndrome is discussed.

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Section: Discussionmentioning

confidence: 99%

Hyperostosis of the Clavicle as a Cardinal Symptom for Sapho Syndrome – Presentation and Discussion of a Clinical Case

Andresen,

Reinke,

Radmer

2023

Osteologie

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“… 5 Staphylococcus aureus was the most common organism at osteolytic bone sites (61%, 56.8% in sinuses and 76%, 37.6% in sequestrum/marrow scrapings). 6 …”

Section: Discussionmentioning

confidence: 99%

A Case of Severe Chronic Multifocal Osteomyelitis of the Skull Caused by Klebsiella pneumoniae in Mali

Xu,

Charles,

Ismael

et al. 2023

IDR

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Highly invasive infections caused by Klebsiella pneumonia , which includes bacteremia, liver abscess, meningitis, septic arthritis, and osteomyelitis, in not commonly seen in adult immunocompetent and immunocompromised patients. Here, we report an adult case of chronic multifocal osteomyelitis with severe cranial involvement caused by Klebsiella pneumonia . The patient has a 5-year history of orbital abscess and multiple scalp traumas. CT scan showed right temporal and periorbital osteolysis, multiple parietal osteolysis. The pus was collected twice and routine culture was positive for Klebsiella pneumonia e. Good clinical outcome was achieved with debridement and antibiotic treatment. Microbiologists and clinicians should promptly perform bacteriological cultures on biopsy specimens to facilitate diagnosis when imaging or intraoperative findings of bone infection are suspected, especially in the Mali population.

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“…Furthermore, imaging studies also have limitations in diagnosing chronic osteomyelitisis. While DR examination can be performed in patients with acute infection symptoms, features like xation aseptic loosening, focal osteoporosis, and cortical thinning lack speci city during the subacute or chronic stages of infection [9]. Although CT is more useful than DR in this regard, its application is limited due to poor result sipeci city and increased artifacts caused by metal xators commonly present in patients with chronic osteomyelitisis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the accuracy of 99mTC-MDP and 99mTC-SC bone scanning imaging for the diagnosis of chronic osteomyelitis

Xu,

Tang,

Yin

et al. 2024

Preprint

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Background There is a lack of effective imaging tools for the clinical confirmation of chronic osteomyelitisis. At present, there are few studies/reports on the diagnosis of chronic osteomyelitisis by nuclear medicine at home and abroad. In this study, we retrospectively observed the accuracy of 99mTC-MDP and 99mTC-SC bone scanning imaging for the diagnosis of chronic osteomyelitisis and explored the clinical value of the two nuclear medicine imaging modalities for the diagnosis of chronic osteomyelitisis. Methods Patients who underwent 99mTC-MDP or 99mTC-SC bone scan imaging with surgical treatment for suspected chronic osteomyelitisis in our hospital from January 2019 to December 2022 were retrospectively analyzed. They were categorized into the 99mTC-MDP group and 99mTC-SC group according to their bone scan imaging modality. The bone scan results were also compared with the postoperative pathology and culture results to clarify the accuracy of the two imaging modalities. Results A total of 72 patients were included, including 38 patients in the 99mTC-MDP group and 34 patients in the 99mTC-SC group. A total of 51 patients were diagnosed with chronic osteomyelitisis. Bone scanning imaging in the 99mTC-MDP group showed positive results in 29 cases and negative results in 9 cases, consistent with the final pathologic diagnosis in 24 cases and inconsistent with the final pathologic diagnosis in 14 cases. Bone scanning imaging in the 99mTC-SC group showed positive results in 27 cases and negative results in 7 cases, consistent with the final pathologic diagnosis in 29 cases and inconsistent with the final pathologic diagnosis in 5 cases. The sensitivity, specificity, misdiagnosis rate, leakage rate, positive predictive value, negative predictive value, and accuracy of 99mTC-MDP bone scan for the diagnosis of chronic osteomyelitisis were 80% (20/25), 30.77% (4/13), 69.23% (9/13), 20% (5/25), 68.97% (20/29), and 44.44% (4/9), respectively, 63.16% (24/38); the sensitivity, specificity, misdiagnosis rate, leakage rate, positive predictive value, negative predictive value, and accuracy of 99mTC-SC bone scan for diagnosing chronic osteomyelitisis were 92.31% (24/26), 62.5% (5/8), 37.5% (3/8), 7.69% (2/26), and 88.89% (24/27), respectively, 71.43% (5/7), 85.29% (29/34). The accuracy of the two tests by chi-square test (2) was 2 = 8.25, P < 0.05, so 99mTC-SC bone scanning imaging was more accurate than 99mTC-MDP bone scanning imaging in diagnosing chronic osteomyelitisis. Conclusion Based on the current results, 99mTC-SC has a higher diagnostic accuracy for chronic osteomyelitisis than 99mTC-MDP bone scan imaging.

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Chronic recurrent multifocal osteomyelitis. A narrative and pictorial review

Cited by 22 publications

References 81 publications

Hyperostosis of the Clavicle as a Cardinal Symptom for Sapho Syndrome – Presentation and Discussion of a Clinical Case

Hyperostosis of the Clavicle as a Cardinal Symptom for Sapho Syndrome – Presentation and Discussion of a Clinical Case

A Case of Severe Chronic Multifocal Osteomyelitis of the Skull Caused by Klebsiella pneumoniae in Mali

Comparison of the accuracy of 99mTC-MDP and 99mTC-SC bone scanning imaging for the diagnosis of chronic osteomyelitis

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