Chronic recurrent multifocal osteomyelitis: a case of orbital involvement

Sia, Paul Ikgan; Rajak, Saul; Kokavec, Jan; Moore, Lynette; Selva, Dinesh

doi:10.1080/24725625.2017.1320465

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Ocular involvement as retinal vasculitis, optic neuropathy, central retinal artery occlusion and orbital inflammation has been reported in patients with CRMO ( 139 – 141 ). In patients with SAPHO syndrome, eye inflammatory lesions may occur as anterior scleritis, anterior uveitis, retinal vasculitis and Vogt-Koyanagi-Harada disease ( 142 – 146 ).…”

Section: Ocular Manifestations Of Polygenic Autoinflammatory Diseasesmentioning

confidence: 99%

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Fonollosa,

Carreño,

Vitale

et al. 2024

Front. Ophthalmol.

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Autoinflammatory diseases include disorders with a genetic cause and also complex syndromes associated to polygenic or multifactorial factors. Eye involvement is present in many of them, with different extent and severity. The present review covers ophthalmological lesions in the most prevalent monogenic autoinflammatory diseases, including FMF (familial Mediterranean fever), TRAPS (TNF receptor-associated periodic syndrome), CAPS (cryopyrin-associated periodic syndromes), Blau syndrome, DADA2 (deficiency of adenosine deaminase 2), DITRA (deficiency of the interleukin-36 receptor antagonist), other monogenic disorders, including several ubiquitinopathies, interferonopathies, and the recently described ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome, and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Among polygenic autoinflammatory diseases, ocular manifestations have been reviewed in Behçet’s disease, PFAPA (periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis) syndrome, Still’s disease and autoinflammatory bone diseases, which encompass CRMO (chronic recurrent multifocal osteomyelitis) and SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome.

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Section: Ocular Manifestations Of Polygenic Autoinflammatory Diseasesmentioning

confidence: 99%

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Fonollosa,

Carreño,

Vitale

et al. 2024

Front. Ophthalmol.

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“…Complications secondary to persistent hyperostosis of the clavicle have been described including neurovascular compression, such as thoracic outlet syndrome [12,18,47,54]. Multiple cases of occipital, facial, and orbital bone involvement were reported resulting in recurrent headaches, periorbital swelling, and facial palsy [55][56][57][58][59].…”

Section: Neurological and Vascular Complicationsmentioning

confidence: 99%

Not all benign: disease course, complications, and sequalae of chronic recurrent multifocal osteomyelitis in children

Yasin

Sato

Ferguson

2022

Current Opinion in Rheumatology

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Purpose of reviewAdvances in pathogenesis of chronic recurrent multifocal osteomyelitis in children (CRMO) have shaped therapeutic strategies. The use of whole-body MRI (WBMRI) and improved awareness of CRMO has increased rates and timeliness of CRMO diagnoses. In this review, we highlight the findings from recently published CRMO cohorts and describe the course, complications, and long-term sequalae of CRMO. It is important for clinicians to be aware of the potential for long-term sequelae in order to optimize therapy and avoid complications.Recent findingsDespite recent advances in defining disease pathogenesis, children with CRMO continue to suffer from complications and deformities. Involvement of the spine can be asymptomatic and is not as rare as previously suggested. This can result in damaging outcomes, such as vertebral fractures and permanent deformities. A subset of patients has polycyclic disease course and some continue to have active disease for years and well into adulthood, with significant impacts on quality of life.SummaryThese recent findings have considerable implication on clinical practice regarding diagnosis, treatment, and monitoring of the disease. Collectively, they support the need for continued monitoring of the disease and screening using comprehensive imaging, such as WBMRI.

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“…Infective and inflammatory processes, such as osteomyelitis (e.g., tuberculous, other bacterial infection, or chronic recurrent multifocal osteomyelitis) and, more rarely, cholesterol granuloma, can cause both erosive and destructive orbital roof changes. 25–27…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

“…Hence, lesion excision without orbital roof reconstruction may be effective. 15,21,23,26 For example, curettage of granulomatous lesions without orbital roof reconstruction can be curative without complications or adverse outcomes from the residual ORD (as large as 2.5 × 2.0 cm). 27 Some bony lesions can also reossify, such as those left by solitary eosinophilic granuloma.…”

Section: When To Treatmentioning

confidence: 99%

“…24 Infective and inflammatory processes, such as osteomyelitis (e.g., tuberculous, other bacterial infection, or chronic recurrent multifocal osteomyelitis) and, more rarely, cholesterol granuloma, can cause both erosive and destructive orbital roof changes. [25][26][27] In the pediatric population, unilateral acquired ORD can result from benign and malignant tumors such as juvenile ossifying fibroma and osteosarcoma, respectively. Bilateral cases can develop from Langerhans cell histiocytosis, 28 and metastases from neuroblastoma for example.…”

Section: Ordmentioning

confidence: 99%

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The Management of Orbital Roof Fractures and Defects: A Review

Sandhu

Bucur²,

Good

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To explore the anatomy, etiopathogenesis, diagnosis and classification, current evidence on intervention and the surgical management of orbital roof fractures and defects (ORFD) for oculoplastic surgeons presented with such cases. Methods: A review of the current literature through the MEDLINE database using the following search terms: “orbital roof fracture (+treatment/management),” “orbital roof defect (+treatment/management),” “orbital roof erosion (+treatment/management),” “orbital roof repair,” “orbital roof,” “orbital fracture,” “pediatric orbital roof (defect/fracture/erosion),” “orbital anatomy,” and “orbital roof anatomy” was conducted. As relatively little has been published on this topic, inclusion criteria were broad and peer-reviewed articles judged to be of clinical importance, relevant to the aims of this review, were included. Non-English abstracts were also included if relevant. Year of publication was not a strict exclusion criterion, and older articles were judged for their suitability based on clinical importance and relevance to current practice. Additional references were obtained from citations in key articles and recommendations from the coauthors based on their areas of expertise. Results: The etiopathogenesis of ORFD varies. Classification systems have been formulated to guide management decisions and can range from conservative management to complex neurosurgery. Eyelid approaches have also been described. This review provides a summary of the evidence for each and a management framework oculoplastic surgeons can use when presented with ORFD. Conclusion: Oculoplastic surgeons can be involved, either alone or as part of a multidisciplinary team, in the management of ORFD, and for some, conduct orbital approach reconstructive surgery.

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Chronic recurrent multifocal osteomyelitis: a case of orbital involvement

Cited by 5 publications

References 13 publications

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Update on ocular manifestations of the main monogenic and polygenic autoinflammatory diseases

Not all benign: disease course, complications, and sequalae of chronic recurrent multifocal osteomyelitis in children

The Management of Orbital Roof Fractures and Defects: A Review

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