Chronic REM-sleep deprivation induced laryngopharyngeal reflux in rats: A preliminary study

Zhang, Yanping; Jiang, Xingwang; Chen, Hao; Li, Heyun; Wang, Zhenhua; Chen, Yuankai; Li, Li

doi:10.1016/j.anl.2020.10.011

Cited by 4 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acid suppressive therapy with PPIs has been internationally recognized as the preferred drug treatment for LPRD. However, in recent years, due to the comprehensive influence of various factors such as diet, 4 sleep, 5 , 6 and work stress, 7 some patients still show no significant improvement in LPRD symptoms after acid-suppressive therapy; in one study, PPIs and a placebo showed no significant difference in improving the symptoms of LPRD patients. 8 Further, because of the limitations of clinical tools, many symptoms and extrapharyngeal manifestations were not considered.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Refractory Laryngopharyngeal Reflux Disease and Symptoms of Anxiety and Depression

Huang¹,

Liao²,

Gan³

et al. 2022

NDT

View full text Add to dashboard Cite

Background and Study Aims The occurrence, development, and prognosis of refractory laryngopharyngeal reflux disease (LPRD) may be related to anxiety and depression. Our study aims to investigate anxiety and depressive symptoms in LPRD and clarify the correlations among them. Patients and Methods Twenty-eight patients were diagnosed with LPRD and subsequently referred to the Department of Mental Health for treatment. The patients were divided into the Self-rating Anxiety Scale (SAS)/Self-rating Depression Scale (SDS) positive group (+) and the SAS/SDS negative group (−). All patients were treated (oral administration) with a standard dose of proton pump inhibitor (PPI, omeprazole 20 mg bid) plus one tablet of Deanxit (flupentixol-melitracen) after breakfast. Treatment efficacy was evaluated after one month of drug treatment. The therapeutic effect of PPI treatment alone was compared with that treated with PPI + Deanxit. Results Among 28 patients with refractory LPRD, the main reflux symptoms and signs were specific. There were differences in gender distribution and age distribution among the 28 patients with refractory LPRD, and there were 17 patients (60.7%) in the SAS/SDS (+) group and 11 patients in the SAS/SDS (−) group (39.3%). Regarding efficacy evaluation after one month of PPI + Deanxit treatment, the differences in indices before and after treatment were statistically significant (all p <0.05). Conclusion Anxiety and depressive symptoms influence the occurrence, development, and treatment efficacy of refractory LPRD. Attention to and targeted treatment of anxiety and depressive symptoms can help improve the treatment outcomes of patients with refractory LPRD.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation Between Refractory Laryngopharyngeal Reflux Disease and Symptoms of Anxiety and Depression

Huang¹,

Liao²,

Gan³

et al. 2022

NDT

View full text Add to dashboard Cite

show abstract

“…It has been stated that any irregularity in this rhythm may affect the symptoms and pathogenesis of gastrointestinal diseases [76]. It has been shown that laryngopharyngeal reflux occurs in rats with chronic sleep deprivation and the reason for this is the occurrence of dysfunction in the central nervous system due to sleep deprivation and consequently, impairment in the control of gastrointestinal system motility [77]. It has even been reported that sleep deprivation may affect intestinal dysbiosis, which is one of the most important underlying causes of digestive system diseases, and may increase colitogenic microbiota [78].…”

Section: Sleep Deprivation and The Gastrointestinal Systemmentioning

confidence: 99%

The role of sleep deprivation in physiological system dysfunctions

Hamit Uslu,

Gözde Atila Uslu

2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Night shifts, long working hours of healthcare professionals, irregular lifestyles, due to increasing economic difficulties and decreasing purchasing power, people have to accept difficult working conditions, resulting in inadequate and/or poor quality sleep problems. Sleep is a physiological need and the emergence of sleep problems not only negatively affects the performance and quality of life of the person during the day, but also causes various changes in the physiological systems and functions of these systems. Sleep problems are often ignored by people in spite of the fact that it is generally a health problem that can be treated by doctors. In this review, as a result of the current literature review, the nervous, cardiovascular and gastrointestinal systems are the most affected systems by sleep deprivation, and the effects of sleep deprivation on these systems and the mechanisms underlying these effects are summarized. It is an undeniable fact that sleep is a physiological need, and that insufficient and/or poor quality sleep will adversely affect physiological functions. However, the existence of conflicting studies and the fact that the physiological and pathological mechanisms in this process have not been elucidated indicate that long-term and more comprehensive studies are needed.

show abstract

“…The proportion of normal people, especially young people, with unhealthy living habits such as sleep disorder and high-fat diet has increased significantly. At the same time, studies have confirmed that patients with LPRD disease are usually accompanied by psychological disorders, and anxiety and depression are more common in people with sleep disorders ( 7 ). In this study, we conducted a comprehensive analysis of the clinical symptoms, sleep, and diet of the patients seeking treatment, aiming to explore the correlation between LPRD and the sleep status of patients and the influencing factors of their onset, so as to provide more data reference for the clinical prevention and treatment of LPRD.…”

Section: Introductionmentioning

confidence: 96%

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Liu

Xiao

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

ObjectiveTo observe the correlation between laryngopharyngeal reflux disease (LPRD) and patients' sleep status, and to explore the related factors of LPRD.MethodsFour hundred and sixteen patients who visited the otorhinolaryngology clinic in our hospital from June 2019 to June 2021 were selected as the research subjects. According to the scale of reflux symptom index, the subjects were divided into a patients group (120 patients) with an the reflux symptom index (RSI) > 13 and a control group (296 patients) with an RSI ≤ 13 according to the RSI scale score. General patient information was collected. The sleep state and emotional state of patients in the two groups were evaluated, and the related influencing factors for LPRD were also evaluated. The correlation between sleep state and depression in LPRD patients was analyzed.ResultsFour hundred and sixteen patients were divided into patients group and control group according to RSI score, the ratio of the two groups was 1:2.47. In the patients group, the common symptoms of RSI score and the top three of the total score were as follows: Foreign body sensation in throat in 112 patients, 438 points; Keep voice clear in 108 patients, 381 points; Excessive phlegm or nasal discharge reflux in 101 patients, 348 points. The PSQI and HADS scores in the patients group were higher than those in the control group (t = 19.990, 13.007, 14.690, P all <0.001). Logistic regression analysis showed that high-fat diet and high PSQI score were the risk factors for the development of LPRD (P = 0.012, P = 0.007). According to the PSQI score, the patients in the patients group were divided into 35 patients with abnormal PSQI score, 85 patients with normal PSQI score, and the HADS scores of those with abnormal PSQI score were all lower than those with normal PSQI score (P > 0.05). The PSQI score of the patients in the patients group was positively correlated with the HADS score (r = 0.714, P = 0.013).ConclusionSleep disorder may lead to the occurrence or aggravation of anxiety and depression in patients with LPRD, and it is an independent risk factor for the development of LPRD. Clinical attention to the treatment of sleep disorders in patients with LPRD may be conducive to improving the efficacy of LPRD.

show abstract

Chronic REM-sleep deprivation induced laryngopharyngeal reflux in rats: A preliminary study

Cited by 4 publications

References 25 publications

Correlation Between Refractory Laryngopharyngeal Reflux Disease and Symptoms of Anxiety and Depression

Correlation Between Refractory Laryngopharyngeal Reflux Disease and Symptoms of Anxiety and Depression

The role of sleep deprivation in physiological system dysfunctions

Correlation and Influencing Factors Between Laryngopharyngeal Reflux Disease and Sleep Status in Patients

Contact Info

Product

Resources

About