Chronic Renal Failure and Skin Calcifications

Nephrogenic fibrosing dermopathy (NFD) is a disorder characterized by dramatic thickening and hardening of skin in the extremities and trunk, which occurs in individuals on dialysis for renal disease. The pathophysiology is unknown. Increased transforming growth factor-beta (TGF-beta) and collagen deposition have been reported in a small group of patients studied by Jimenez et al.1 We report two patients with NFD and osteoclast-like giant cells in the fibrotic dermis; one patient also had dystrophic cutaneous calcification. These findings have been seen in a small percentage of NFD patients (estimated 2-5%) and may represent a variant of the disease. The hypothesis of altered matrix dysregulation due to altered TGF-beta, metalloproteinases, and activation of osteoclasts as an explanation for this variant is proposed.

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“…The cutaneous calcification in chronic renal failure is traditionally divided into three categories: 11 …”

Section: Discussionmentioning

confidence: 99%

“…In one of our patients, patient 2, diffuse dermal calcification (dystrophic calcinosis) was present. The cutaneous calcification in chronic renal failure is traditionally divided into three categories: 11 1. Metastatic or dystrophic calcinosis, which is associated with secondary hyperparathyroidism.…”

Section: Dystrophic Calcificationmentioning

confidence: 99%

A variant of nephrogenic fibrosing dermopathy with osteoclast‐like giant cells: a syndrome of dysregulated matrix remodeling?

et al. 2004

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“…The main responsible factor for ectopic calcification seems to be a calcium‐phosphorous product higher than 70 mg/mL (1,2). Patients with renal failure, paraneoplastic hypercalcemia, hypervitaminosis D, hyperparathyroidism, milk alkali syndrome, sarcoidosis, and destructive bone disease may develop metastatic deposits of calcium (3). Calcinosis cutis after liver transplantation has been described in a pediatric patient.…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Cutis Following Trauma

Larralde

Giachetti

Cáceres

et al. 2005

Pediatric Dermatology

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We report an 8-year-old boy who developed dystrophic calcinosis cutis that occurred following trauma. Multiple abrasions were observed in the inguinal folds after a soccer game. Subsequently, multiple papules with soft centers and white particles appeared in the same area. A biopsy specimen showed calcinosis cutis with transepidermal elimination of calcium. The causes of the underlying tissue damage associated with dystrophic calcinosis are discussed.

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“…The main responsible factor for ectopic calcification seems to be increased calcium-phosphorus product, greater then 70 mg/ml (7). Patients with renal failure, paraneoplastic hypercalcemia, hypervitaminosis D, hyperparathyroidism, milk alkali syndrome, sarcoidosis, and destructive bone disease may develop metastatic deposits of calcium (8).…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Cutis Following Liver Transplantation in a Pediatric Patient

Larralde

Giachetti

Kowalczuk

et al. 2003

Pediatric Dermatology

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We report the occurrence of calcinosis cutis in a 3-year-old girl after liver transplantation. The cutaneous lesions consisted of 5 mm white papules on an erythematous base in linear and rosette configurations that developed in the abdominal and lumbar areas 10 days after transplantation. The patient had received calcium chloride solution intravenously during surgery. We excluded other causes of ectopic calcification such as hyperparathyroidism, renal failure, and extravasation of calcium solution. We discuss the etiology of calcinosis cutis after liver transplantation. This sequence of events has not been previously described in pediatric patients.

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Chronic Renal Failure and Skin Calcifications

Cited by 9 publications

References 4 publications

A variant of nephrogenic fibrosing dermopathy with osteoclast‐like giant cells: a syndrome of dysregulated matrix remodeling?

A variant of nephrogenic fibrosing dermopathy with osteoclast‐like giant cells: a syndrome of dysregulated matrix remodeling?

Calcinosis Cutis Following Trauma

Calcinosis Cutis Following Liver Transplantation in a Pediatric Patient

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