Chronic renal failure does not affect the mouse locomotor activity in darkness conditions

Monge, Matthieu; Houben, Thijs; Boer, Helen de; Aleksinskaya, Marina; Massy, Ziad A.; Rabelink, Ton J.; Meijer, Johanna H.; Zonneveld, Anton Jan van

doi:10.1080/09291016.2012.745058

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…In the present study, CRF mice did not show abnormally low levels of locomotor activity or exploratory behavior. This finding agrees with a previous study (in the same murine model) in which locomotor activity in the dark was normal [ 20 ]; this was considered to indicate that uremic toxins do not impair the central circadian pacemaker [ 20 ].…”

Section: Discussionsupporting

confidence: 93%

Neurological Disorders in a Murine Model of Chronic Renal Failure

Chillon

Brazier

Bouquet

et al. 2014

Toxins

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Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce—despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety).

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Section: Discussionsupporting

confidence: 93%