Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T

Kim, Sang-Young; Lee, Do-Wan; Kim, Hyun-Ju; Bang, Eunjung; Chae, Jeong‐Ho; Choe, Bo-Young

doi:10.1016/j.neulet.2014.04.033

Cited by 24 publications

(16 citation statements)

References 25 publications

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“…Depression is associated with decreased function of GABA in the brain (Rosa, Neis, Ribeiro, Moretti, & Rodrigues, ; Zarrindast & Mahmoudi, ). Our study shows that the levels of 5‐HT, NE, DA, and GABA in the hippocampus decreased in CUMS mice compared with the control group, also consistent with previous studies (Kim et al, ; Xu et al, ). Administration of DS and PAR reversed the reduction in hippocampal 5‐HT, NE, DA, and GABA levels induced by CUMS, with the increase in 5‐HT level in the hippocampus being especially significant.…”

Section: Discussionsupporting

confidence: 93%

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

Jiang

Beiyue

Dong

et al. 2018

Phytotherapy Research

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Depression is a common, dysthymic, and psychiatric disorder, resulting in enormous social and economic burden. Dammarane sapogenins (DS), an active fraction from oriental ginseng, has shown antidepressant-like effects in chronic restraint rats and sleep interruption-induced mice, and the present study aimed to further confirm the antidepressant effects of DS in a model of chronic unpredictable mild stress (CUMS) and to explore the underlying mechanism. Oral administration of DS (20, 40, and 80 mg/kg) markedly improved depressant-like behaviors, increasing the sucrose intake in the sucrose preference test and reducing the latency in the novelty-suppressed feeding test, and decreasing the immobility time in both the tail suspension and forced swimming tests, compared with the CUMS mice. Biochemical analysis of brain tissue and serum showed that DS treatment restored the decreased hippocampal neurotransmitter concentrations of serotonin, dopamine, norepinephrine (noradrenaline), and gamma-aminobutyric acid, and decreased the elevated of serum hormone levels (corticotrophin releasing factor, adrenocorticotrophic hormone, and corticosterone) induced by CUMS. Our findings confirm that DS exerts an antidepressant-like effect in the CUMS model of depression in mice, and suggest it may be mediated by regulation of neurotransmitters and hypothalamic-pituitary-adrenal axis.

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Section: Discussionsupporting

confidence: 93%

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

Jiang

Beiyue

Dong

et al. 2018

Phytotherapy Research

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“…However, while TMS is also effective in reversing behavioural and neurochemical abnormalities in animal models of depression (e.g. Keck et al 2001;Feng et al 2012;Kim et al 2014;Wang et al 2014), to our knowledge, TMS has not yet been tested in any of the models listed in Table 1 that are of interest in relation to treatment-resistant depression.…”

Section: Response To Novel Antidepressantsmentioning

confidence: 99%

Treatment-resistant depression: are animal models of depression fit for purpose?

2015

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“…(Janicak and Dokucu, 2015;Jassova et al, 2018;Paes et al, 2013). The current view is that rTMS may play an anti-depressant and anti-anxiety role by regulating the activity and regeneration of neurons, affecting the expression of neurotransmitters (Kim et al, 2014;Tan et al, 2013). Its role in epilepsy comorbid with depression and anxiety, however, is unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats

Wang

Mao

Yao

et al. 2019

J. Integr. Neurosci.

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Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been considered as a treatment option for depression and anxiety. However, its role in epilepsy comorbid with depression and anxiety is unclear. Therefore, we evaluated whether low-frequency rTMS can alleviate depression-and anxiety-like behavior in epileptic rats. Forty-eight adult rats were allocated at random to four groups: Control, Pentylenetetrazol (PTZ), PTZ-rTMS and PTZ-Sham. The control group received intraperitoneal injections of normal saline, while the other groups received intraperitoneal injections of pentylenetetrazol (35 mg/kg/d) once a day for 15 days. Low-frequency rTMS or sham stimulation were administered to the PTZ-rTMS and PTZ-Sham group, respectively, over the two-week period. The open-field test (OFT), elevated plus-maze test (EPM) and forced swimming test (FST) were carried out before the experiment, on the 8th and 15th day to assess depression-and anxiety-like behavior in the rats. Two weeks of low-frequency rTMS treatment could not impair the increases of seizure severity in epileptic rats. However, relative to the PTZ and PTZ-Sham group, the twoweek low-frequency rTMS treatment significantly reduced the immobility time in the forced swimming test and attenuated the progressive decrease in total distance traveled, frequency of rearing, velocity in the open-field test, number of entries in the open arms (%) and the time spent in the open arms (%) in the elevated plus-maze test of the PTZ-rTMS group. We proposed that low-frequency rTMS can benefit epileptic rats via amelioration of comorbid depression and anxiety, but it can not alleviate the seizure severity.

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Chronic repetitive transcranial magnetic stimulation enhances GABAergic and cholinergic metabolism in chronic unpredictable mild stress rat model: 1H-NMR spectroscopy study at 11.7 T

Cited by 24 publications

References 25 publications

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress‐induced depressive mice

Treatment-resistant depression: are animal models of depression fit for purpose?

Effects of low-frequency repetitive transcranial magnetic stimulation on depression- and anxiety-like behaviors in epileptic rats

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