Chronic Respiratory Symptoms and Lung Abnormalities Among People With a History of Tuberculosis in Uganda: A National Survey

Kampen, Sanne van; Jones, Rupert; Kisembo, Harriet; Houben, Rein M. G. J.; Wei, Yinghui; Mugabe, Frank; Rutebemberwa, Elizeus; Kirenga, Bruce

doi:10.1093/cid/ciy795

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…This might have been influenced by factors known to affect interpretation of x-rays including patient rotation or radiographs being taken in expiration. (5) We did not have functional outcomes such as pulmonary function tests or 6-minute walk test (6MWT), and these would be important to include in a prospective J o u r n a l P r e -p r o o f study. However, it has previously been reported that the CXR score employed in this work correlates inversely with 6MWT and forced expiratory volume in 1 second (FEV1) and positively with the St George's Respiratory Questionnaire (SGRQ) score, indicating poorer quality of life [14].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…However, treated patients often have significant residual lung damage comprising persistent cavities, bronchiectasis and volume loss (including from pleural scarring) [2]. Tuberculosis is thus not only a cause of acute infectious mortality but also of chronic morbidity [3][4][5] and premature death from later complications. This has been increasingly appreciated recently with the first international symposium on post-tuberculosis lung disease being held in 2020 [6].…”

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confidence: 99%

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The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

Jones

Dabbaj

Mandal

et al. 2021

Chest

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

mentioning

confidence: 99%

The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

Jones

Dabbaj

Mandal

et al. 2021

Chest

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“…Previous evidence indicated that for the greatest delays, patient outcomes were worse. DD in PTB may cause more severe damage to the lungs [31], therefore such patients are at a high risk of respiratory complications, such as bronchiectasis and hemoptysis, which may complicate anti-TB treatments and impede recovery [32][33][34]. Moreover, previous evidence also reported that DD was a major risk factor for TB-related death [35].…”

Section: Discussionmentioning

confidence: 99%

Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

et al. 2022

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Background Tuberculosis (TB) is one of the main infectious diseases that seriously threatens global health, while diagnostic delay (DD) and treatment dramatically threaten TB control. Methods Between 2005 and 2017 in Shandong, China, we enrolled pulmonary tuberculosis (PTB) patients with DD. DD trends were evaluated by Joinpoint regression, and associations between PTB patient characteristics and DD were estimated by univariate and multivariate logistic regression. The influence of DD duration on prognosis and sputum smear results were assessed by Spearman correlation coefficients. Results We identified 208,822 PTB cases with a median DD of 33 days (interquartile range (IQR) 18–63). The trend of PTB with DD declined significantly between 2009 and 2017 (annual percent change (APC): − 4.0%, P = 0.047, 2009–2013; APC: − 6.6%, P = 0.001, 2013–2017). Patients aged > 45 years old (adjusted odds ratio (aOR): 1.223, 95% confidence interval (CI) 1.189–1.257, 46–65 years; aOR: 1.306, 95% CI 1.267–1.346, > 65 years), farmers (aOR: 1.520, 95% CI 1.447–1.596), and those with a previous treatment history (aOR: 1.759, 95% CI 1.699–1.821) were prone to developing long DD (> 30 days, P < 0.05). An unfavorable outcome was negatively associated with a short DD (OR: 0.876, 95% CI 0.843–0.910, P < 0.001). Sputum smear positive rate and unfavorable outcomes were positively correlated with DD duration (Spearman correlation coefficients (rs) = 1, P < 0.001). Conclusions The DD situation remains serious; more efficient and comprehensive strategies are urgently required to minimize DD, especially for high-risk patients.

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“…To date, much of the evidence about adverse health consequences post TB treatment has come from countries with a relatively low burden of TB (van Kampen et al, 2018a); there are limited data from high TB incidence settings. Population-based studies in Uganda ( van Kampen et al, 2018b) and South Africa (Hnizdo et al, 2000;Amaral et al, 2015;Buist et al, 2007;den Boon et al, 2007) have revealed a high burden of respiratory symptoms, chest X-ray abnormalities, and moderate to severe COPD, associated with a history of previous TB treatment. FTB patients constitute a large group (10/ 1000 population) in the adult population in several high TB burden communities in South Africa and also account for a considerable fraction of prevalent TB (19%) (den Boon et al, 2007;Marx et al, 2016aMarx et al, 2016a, suggesting opportunities for targeted TB control measures in this population (Marx et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa: A pilot study

Osman

Welte

Dunbar

et al. 2019

International Journal of Infectious Diseases

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Background: A high risk of tuberculosis (TB), chronic lung disease, and mortality have been reported among people with a history of previous TB treatment, but data from high-incidence settings remain limited. The aim of this study was to characterize general morbidity and mortality among adults who had successfully completed TB treatment in the past 5 years in a high-incidence setting in South Africa. Methods: Adults (18 years) who had completed treatment for pulmonary TB between 2013 and 2017 were randomly selected from TB treatment registers. Household visits were conducted to locate and interview former TB (FTB) patients, and bacteriological testing for TB was offered. Additional data sources were used to ascertain the vitality status of FTB patients who could not be located. Results: Addresses were located for 200 of the 223 FTB patients sampled and 89 FTB patients were contacted of whom 51 agreed to be interviewed. Approximately half reported persistent respiratory symptoms, such as shortness of breath and wheezing, and repeated lung infections. One (3.6%) of 28 patients who provided a sputum sample had culture-positive TB and another two were currently on re-treatment for TB. Fifteen deaths post treatment were ascertained, resulting in a standardized mortality ratio of 3.8 (95% confidence interval 2.3-6.3) after successful TB treatment relative to the general population. Conclusions: In this high-incidence setting, locating and interviewing FTB patients was challenging. The study findings are consistent with a high rate of respiratory disease, including recurrent TB, and substantially elevated mortality among FTB patients.

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Chronic Respiratory Symptoms and Lung Abnormalities Among People With a History of Tuberculosis in Uganda: A National Survey

Abstract: Among the general population of Uganda, ex-TB patients are at high risk of chronic cough, phlegm, chest pain, haemoptysis and chest x-ray abnormalities. A history of TB was a greater predictor of chronic respiratory problems than old age or smoking.

Cited by 7 publications

References 23 publications

The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End

Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa: A pilot study

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