Chronic rhinosinusitis

Friedman, Ray L.; Hockman, M

doi:10.1080/10158782.2010.11441370

Cited by 4 publications

(8 citation statements)

References 1 publication

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“…Predisposing factors include cystic fibrosis and acquired immunodeficiency [15]. Clinically, the symptoms of CRS are similar to those in ARS (Table 1) [19]. In recent years, persistent and recurrent CRS has been linked to bacterial biofilms capable of adhering to the nasal and paranasal mucosa [10].…”

Section: Rhinosinusitismentioning

confidence: 88%

“…In recent years, persistent and recurrent CRS has been linked to bacterial biofilms capable of adhering to the nasal and paranasal mucosa [10]. These biofilms represent well-structured bacterial colonies protected by an outer polyssacharide matrix which shows a high resistance to host immune mechanisms [19,20].…”

Section: Rhinosinusitismentioning

confidence: 99%

“…This can be achieved through the rehydration of the ASL allowing it to reach an optimal height in order for cilia to perform its functions effectively and in order to prevent the aggregation of the bacterial biofilm to the sinonasal mucosa [19]. [19].…”

Section: Principles Of Managementmentioning

confidence: 99%

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The Role of Airway Surface Liquid in the Primary Management of Rhinosinusitis

Hendrik¹,

Raubenheimer²

2013

J Interdiscipl Med Dent Sci

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Airway surface liquid forms part of the innate defence mechanism of the respiratory system, including the nasal and paranasal sinuses. Successful mucociliary clearance, which lies at the centre of this defence mechanism, involves the synchronized function of two structures, namely, the periciliary liquid layer and the mucus layer. The two structures have collectively been termed the 'two phase airway surface liquid' system. This system is kept hydrated through regulation of sodium and chloride transport. A well hydrated airway surface liquid that allows the periciliary liquid layer to extend over the height of the outstretched cilia keeping mucus away from the epithelia is considered to be essential for effective mucus clearance and sinonasal health. This mechanism assists in trapping and eliminating foreign particles and, together with antimicrobial peptides, maintains a sterile environment in the nasal and paranasal sinuses, which are continually exposed to microorganisms in the external environment. In diseases such as rhinosinusitis, the mucociliary clearance capacity is diminished; the first line of defence is disrupted allowing for bacterial invasion and infection. This manuscript explores the prospect of an alternative approach for the prophylaxis and primary management of rhinosinusitis based on the maintenance of a well hydrated airway surface liquid.

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Section: Rhinosinusitismentioning

confidence: 88%

Section: Rhinosinusitismentioning

confidence: 99%

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The Role of Airway Surface Liquid in the Primary Management of Rhinosinusitis

Hendrik¹,

Raubenheimer²

2013

J Interdiscipl Med Dent Sci

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“…The concept of "chronic mucosal inflammation" has replaced "infection" to describe chronic rhinosinusitis. 4,5 Nasal polyps are grape-like structures comprising loose connective tissue, oedema, inflammatory cells, glands and capillaries originating from the nose and sinuses. 1 They are covered mostly with respiratory pseudostratified epithelium with ciliated cells and goblet cells.…”

Section: Chronic Rhinosinusitis: Clinicalmentioning

confidence: 99%

“…Allergy is accepted as a cause of chronic rhinosinusitis, but only as one of several factors. 4,5 In order to differentiate between the two symptomatically very similar clinical entities, the concept of Allergic Rhinitis and its Impact on Asthma (ARIA) 2 is presented to facilitate allergic rhinitis diagnosis.…”

Section: Technical Definitionmentioning

confidence: 99%

Chronic sinusitis in children: a general overview

Friedman

2011

South African Family Practice

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Chronic rhinosinusitis

Dickson¹,

Hopkins

2019

InnovAiT: Education and inspiration for general practice

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Chronic rhinosinusitis affects 10.9% of the UK adult population, affecting quality of life and with significant economic cost. The aetiology is unknown, and diagnosis can present challenges. It is characterised by inflammation of the nose and paranasal sinuses that leads to nasal obstruction, discharge, facial pain or pressure and loss of smell, persisting for more than 3 months. Nasal cavity examination aids diagnosis. It is subdivided into chronic rhinosinusitis with and without nasal polyposis. Nasal corticosteroids and saline irrigation make up current baseline management in primary care, with referral to ENT recommended for those with persistent symptoms. Physicians should be alert to persistent unilateral symptoms and the risk of sino-nasal tumours.

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Chronic rhinosinusitis

Cited by 4 publications

References 1 publication

The Role of Airway Surface Liquid in the Primary Management of Rhinosinusitis

The Role of Airway Surface Liquid in the Primary Management of Rhinosinusitis

Chronic sinusitis in children: a general overview

Chronic rhinosinusitis

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