Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity

Shaghayegh, Gohar; Cooksley, Clare; Ramezanpour, Mahnaz; Wormald, Peter‐John; Psaltis, Alkis James; Vreugde, Sarah

doi:10.3390/biomedicines10061362

Cited by 20 publications

(10 citation statements)

References 284 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To protect itself against the host's immune system, S. aureus expresses biofilm. 19 Similarly, P. aeruginosa is an opportunistic pathogen and one of the most common agents of respiratory infections, associated with high morbidity and mortality rates. One of the most fundamental problems in treating P. aeruginosa infections is related to its self-generated biofilms.…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm Activity of Different Washing Solutions against Biofilms in Cystic Fibrosis Patients' Nasal Cavities

Tüzemen¹,

Tüzemen

Alkan

et al. 2023

J Pediatr Infect Dis

View full text Add to dashboard Cite

Objective Bacterial biofilm formation is a multistep process involving bacterial adhesion to inorganic or mucosal surfaces. We aimed to identify Staphylococcus aureus and Pseudomonas aeruginosa strains colonizing the respiratory tracts of cystic fibrosis (CF) patients and to gauge the antibiofilm potential of streptomycin and ozone solutions against them. Methods Bacteria were obtained from CF patients' sputum samples processed in our microbiology laboratory over 1 year (2021–2022). A total of 26 nonduplicate strains (13 S. aureus and 13 P. aeruginosa) were included in this study. Results Both ozone and streptomycin solutions showed significant inhibitory activity. However, when faced with mature biofilm, the streptomycin solution had a significantly more substantial impact than the ozone solution. Furthermore, the ozone solution had no inhibitory effect on mature P. aeruginosa biofilm. Conclusion Ozone and streptomycin solutions might be used as nasal irrigation to eliminate the biofilms in patients with CF in acute respiratory infections. However, our in vitro observations would need to be confirmed in vivo. In chronic inflammation, ozone solution cannot degrade the mature biofilm of P. aeruginosa, whereas streptomycin solution can degrade such biofilms. This result is promising in lessening the biofilms associated with these bacteria that colonize patients with CF.

show abstract

Section: Discussionmentioning

confidence: 99%

Antibiofilm Activity of Different Washing Solutions against Biofilms in Cystic Fibrosis Patients' Nasal Cavities

Tüzemen¹,

Tüzemen

Alkan

et al. 2023

J Pediatr Infect Dis

View full text Add to dashboard Cite

show abstract

“…The inherent self-protective nature of biofilms contributes to chronic infections and device-related issues. Thus, understanding and addressing AMR mechanisms are imperative in managing biofilm-related conditions effectively within ENT [ 15 , 16 ]. Considering these factors influencing biofilm formation in the ENT region, healthcare professionals can effectively devise targeted strategies to prevent, diagnose, and treat biofilm-related conditions within otorhinolaryngology.…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Ghosh Moulic,

Deshmukh,

Gaurkar

2024

Cureus

View full text Add to dashboard Cite

Biofilms, structured communities of microorganisms encased in a self-produced matrix, pose significant challenges in otorhinolaryngology due to their role in chronic and recurrent infections affecting the ear, nose, and throat (ENT) region. This review provides an overview of biofilms, emphasizing their formation, pathogenesis, diagnosis, and treatment strategies in otorhinolaryngological disorders. Biofilms are pivotal in chronic rhinosinusitis (CRS), otitis media, laryngopharyngeal reflux (LPR), and tonsillitis, contributing to treatment resistance and disease recurrence. Current diagnostic techniques, including imaging modalities, microbiological cultures, and molecular techniques, are discussed, alongside emerging technologies. Treatment strategies, ranging from conventional antibiotics to alternative therapies, such as biofilm disruptors, phage therapy, and immunomodulation, are evaluated in terms of their efficacy and potential clinical applications. The review underscores the significance of understanding biofilms in otorhinolaryngology and highlights the need for tailored approaches to diagnosis and management to improve patient outcomes.

show abstract

“…Linked to epithelial barrier damage and tissue remodeling, CRS encompasses three distinct inflammatory patterns, according to the EPOS 2020 Guidelines. These include type 1 inflammation targeting viruses, type 2 inflammation targeting parasites, and type 3 inflammation focusing on extracellular bacteria and fungi ( 2 ). Ordinarily, the clearance of pathogens restores mucosal barrier integrity.…”

Section: Introductionmentioning

confidence: 99%

Genetically predicted chronic rhinosinusitis and the risk of stroke: a two-sample Mendelian randomization study

Hu,

Wang,

Zhou

2024

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveThe causal association between chronic rhinosinusitis (CRS) and stroke remains uncertain due to the susceptibility of observational studies to confounding and the possibility of reverse causality. This study aims to examine the potential causal relationship between CRS and the risk of stroke, encompassing various subtypes.MethodsIn this research, we utilized genome-wide association study (GWAS) data for CRS from FinnGen. We identified significant single-nucleotide polymorphisms (SNPs) associated with CRS and used them as instrumental variables (IVs). GWAS data for any ischemic stroke (AIS), ischemic stroke (IS), large-artery atherosclerotic stroke (LAS), small-vessel strokes (SVS), cardioembolic strokes (CES), intracerebral hemorrhage (ICH), lobar ICH, and non-lobar ICH came from multi-ancestry GWAS datasets. We conducted two-sample Mendelian randomization (MR) analyses using inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to investigate potential causal relationships between CRS and stroke. Both heterogeneity and pleiotropy were evaluated by sensitivity analyses.ResultThe IVW analysis revealed no significant associations between CRS and AIS (OR = 0.99, 95% CI [0.93–1.05], p = 0.73), IS (OR = 0.97, 95% CI [0.81–1.17], p = 0.09), SVS (OR = 0.96, 95% CI [0.82–1.12], p = 0.58), LAS (OR = 0.91, 95% CI [0.77–1.08], p = 0.09), CES (OR = 0.97, 95% CI [0.81–1.17], p = 0.79), ICH (OR = 1.28, 95% CI [0.74–2.22], p = 0.28), lobar ICH (OR = 1.22, 95% CI [0.60–2.50], p = 0.28), and non-lobar ICH (OR = 1.25, 95% CI [0.65–2.40], p = 0.79). Sensitivity analysis found no evidence of horizontal pleiotropy.ConclusionAccording to genetic evidence, this Mendelian randomization (MR) study does not indicate a causal relationship between CRS and stroke in European populations. However, further studies are necessary to comprehensively evaluate the potential association between CRS and stroke.

show abstract

Chronic Rhinosinusitis, S. aureus Biofilm and Secreted Products, Inflammatory Responses, and Disease Severity

Cited by 20 publications

References 284 publications

Antibiofilm Activity of Different Washing Solutions against Biofilms in Cystic Fibrosis Patients' Nasal Cavities

Antibiofilm Activity of Different Washing Solutions against Biofilms in Cystic Fibrosis Patients' Nasal Cavities

A Comprehensive Review on Biofilms in Otorhinolaryngology: Understanding the Pathogenesis, Diagnosis, and Treatment Strategies

Genetically predicted chronic rhinosinusitis and the risk of stroke: a two-sample Mendelian randomization study

Contact Info

Product

Resources

About