Chronic Rhinosinusitis with Nasal Polyps and without Nasal Polyps is Associated with Increased Expression of Lysophosphatidic Acid–Related Molecules

Park, Se Jin; Jun, Young Joon; Lee, Ki Jeong; Hwang, Soo Min; Kim, Tae Hoon; Lee, Jun Young; Lee, Sang Hag

doi:10.2500/ajra.2014.28.4032

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…Another pathway resulting in LPA production involves the hydrolysis of LPC via lysophospholipase D (also called autotaxin) [ 261 ]. Multiple studies suggest that both LPA concentration (specifically polyunsaturated species) and autotaxin levels and activity are increased in allergic diseases and asthma [ 67 , 261 , 262 , 263 ]. Moreover, serum autotaxin levels were found to correlate with pruritus in patients with atopic dermatitis [ 246 ].…”

Section: Phospholipase D Cleavage Product: Lysophosphatidic Acid (Lpa)mentioning

confidence: 99%

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Knuplez

Sturm

Marsche

2021

IJMS

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Eosinophils are important effector cells involved in allergic inflammation. When stimulated, eosinophils release a variety of mediators initiating, propagating, and maintaining local inflammation. Both, the activity and concentration of secreted and cytosolic phospholipases (PLAs) are increased in allergic inflammation, promoting the cleavage of phospholipids and thus the production of reactive lipid mediators. Eosinophils express high levels of secreted phospholipase A2 compared to other leukocytes, indicating their direct involvement in the production of lipid mediators during allergic inflammation. On the other side, eosinophils have also been recognized as crucial mediators with regulatory and homeostatic roles in local immunity and repair. Thus, targeting the complex network of lipid mediators offer a unique opportunity to target the over-activation and ‘pro-inflammatory’ phenotype of eosinophils without compromising the survival and functions of tissue-resident and homeostatic eosinophils. Here we provide a comprehensive overview of the critical role of phospholipase-derived lipid mediators in modulating eosinophil activity in health and disease. We focus on lysophospholipids, polyunsaturated fatty acids, and eicosanoids with exciting new perspectives for future drug development.

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Section: Phospholipase D Cleavage Product: Lysophosphatidic Acid (Lpa)mentioning

confidence: 99%

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Knuplez

Sturm

Marsche

2021

IJMS

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show abstract

“…Our study showed that SOCS1 protein levels were higher in CRSsNP patients than in CRSwNP patients and controls. The study by Park et al showed that SOCS1 and SOCS3 are also expressed in the nasal mucosa of healthy individuals, but in patients with CRSwNP and CRSsNP (both asthma and non-atopic groups), both mRNA and protein levels increased dramatically [ 22 ]. In another study by Hulse and colleagues in the US, the level of SOCS3 by western blotting was significantly reduced [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis

Ghalehbaghi,

Aazami,

Khoshmirsafa

et al. 2024

Yale J Biol Med

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“…25 Thymic stromal lymphopoietin (TSLP) and lysophosphatidic acid (LPA) have also been demonstrated to be higher in patients with eosinophilic CRSwNP and within CRSwNP and CRSsNP patients compared to control patients, respectively. 5,30 Mediator major basic protein (MBP), which can trigger the release of histamine, was found in one study to be elevated in 87% of CRSwNP patients versus only 4% of controls. 12 This observation was confirmed in another study that added that MBP was absent in the nasal mucus of patients with AR.…”

Section: Nasal Mucus Inflammatory Markers and Disease Severitymentioning

confidence: 99%

Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis

Parra-Ferro

Justice

Lobo

et al. 2022

Am J Rhinol�Allergy

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Background Nasal mucus is proving to be a useful means by which to study the pathogenesis of chronic rhinosinusitis (CRS). Given the increase in publications examining nasal mucus and the lack of a review on this topic, we will focus on this noninvasive approach to studying CRS. Particular attention will be drawn towards inflammatory cytokines and biomarkers and their influence on disease severity. Methods A literature review of papers published in English pertaining to nasal mucus was performed using the PubMed database. The search utilized combinations of the following keywords: sinusitis, polyps, sample collection, nasal mucus, or nasal secretion. Studies solely on acute or bacterial sinusitis, allergic rhinitis, or cystic fibrosis were not included. Results A wide variety of materials and methods have been used to collect nasal mucus. Numerous assay types have been performed with the most common being ELISA, cytometric bead array, and proteomics. Most studies have focused on examining the levels of Th1/Th2 cytokines along with chemokines associated with type 2 immunity. Other factors identified include growth factors, senescence-associated proteins, complement, and antimicrobial defenses have also been identified. Nasal mucus cytokines have proven useful in cluster analysis and predicting postoperative improvement in Sino-nasal Outcome Test (SNOT-22) scores. One limitation of the use of nasal mucus is that some studies have suggested that nasal mucus does not always reflect the tissue microenvironment. Conclusions Nasal mucus represents a critical tool by which to examine the sinonasal microenvironment in a noninvasive manner. Unlike studies of tissue, it can be utilized in both surgically and medically managed patients and avoids the trauma of biopsies. However, studies are still needed to determine the most effective method for nasal mucus collection. Studies should also take care to confirm that nasal mucus markers do, in fact, reflect the levels of the product studied in the tissue.

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Chronic Rhinosinusitis with Nasal Polyps and without Nasal Polyps is Associated with Increased Expression of Lysophosphatidic Acid–Related Molecules

Abstract: LPA in human sinus mucosa may play important roles in the pathogenesis of CRS, contributing to produce CRS-related cytokines. LPA-related molecules were increased in CRS, which may attribute to CRS-related cytokines.

Cited by 6 publications

References 43 publications

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids

Suppressor of Cytokine Signaling Proteins 3 and 5 Potentially Delineate Polarization of Th cells in Chronic Rhinosinusitis

Utilization of Nasal Mucus to Investigate the Pathophysiology of Chronic Rhinosinusitis

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