Chronic rhinosinusitis with polyposis and serum vitamin D levels

Bavi, F; Movahed, Rahman; Salehi, Maryam; Hossaini, Sina; Bakhshaee, Mehdi

doi:10.14639/0392-100x-2439

Cited by 10 publications

(11 citation statements)

References 32 publications

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“…24 Vitamin D has a known immunoregulatory function, and epidemiologic studies have shown that vitamin D insufficiency is common in immune disorders and some infectious diseases. 17,25,26 Furthermore, vitamin D exerts an inhibitory action on the adaptive immune system. 27 A normal level of vitamin D suppresses the production of proinflammatory cytokines, and this has been shown in patients with congestive heart failure as well as in experimental bowel diseases.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Serum Vitamin D Level and Ménière’s Disease

Bakhshaee

Moradi²,

Mohebi

et al. 2021

Otolaryngol.--head neck surg.

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Objectives Ménière’s disease (MD) is a well-known inner ear disease; however, the etiopathogenesis is unknown. Several factors may be involved. Meanwhile, vitamin D is reported to have an important role in inner ear physiology. The aim of this study is to evaluate the relation between vitamin D deficiency and MD. Study Design This matched case-control study compared serum vitamin D levels between patients with definite MD and those without it. Setting The study was done between August 2018 and December 2019 at Ghaem University Hospital in Mashhad, Iran. Methods Twenty-eight patients with definite MD were matched with a group of 84 healthy individuals, regarding age, sex, body mass index, and occupation (indoor vs outdoor). The serum level of vitamin D (25-hydroxyvitamin D3) was measured in both groups. Results The mean ± SD vitamin D level was 18.9 ± 9.7 ng/mL in the case group and 25.2 ± 13.7 ng/mL in the control group ( P = .027). There was a significant difference between the case and control groups according to the results of the conditional logistic regression model ( P = .03; adjusted odds ratio, 0.96). In the MD group, 17 (60.7%) patients were vitamin D deficient, 6 (21.4%) insufficient, and only 5 (17.9%) sufficient. Conclusions The results of this study show that serum vitamin D level in MD is significantly lower than that of the control group. However, the role of vitamin D supplementation in the management of MD needs further study. Level of evidence: 4.

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Section: Discussionmentioning

confidence: 99%

“…Vitamin D has a known immunoregulatory function, and epidemiologic studies have shown that vitamin D insufficiency is common in immune disorders and some infectious diseases 17,25,26 . Furthermore, vitamin D exerts an inhibitory action on the adaptive immune system 27 .…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum Vitamin D Level and Ménière’s Disease

Bakhshaee

Moradi²,

Mohebi

et al. 2021

Otolaryngol.--head neck surg.

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“…Bavi et al reported quite low levels of vitamin D in CRS with nasal polyps at 12.11 ± 6.27 ng/mL, while in the control group, the levels were 90 ± 17.18 ng/mL. There was a negative correlation between serum vitamin D3 level and the Lund-Mackay score (R = -0.66) [ 11 ]. Similarly, Chandrakar et al described vitamin D levels of 12.01 ± 7.29 ng/mL in cases, while in controls, the levels were 22.87 ± 14.95 ng/mL.…”

Section: Reviewmentioning

confidence: 99%

“…Numerous studies have demonstrated that vitamin D3 can suppress immune cell differentiation and cytokine production. Some studies indicate that local calcitriol and tacalcitol block the production/synthesis of pro-inflammatory cytokines interleukin (IL) 6 and 8 in fibroblast cultures and that local regulation of vitamin D in the sinonasal tissue during CRS may be independent of serum 25(OH)-D levels [ 11 ].…”

Section: Reviewmentioning

confidence: 99%

The Correlation Between Vitamin D Deficiency and Chronic Rhinosinusitis: A Systematic Review

Alharthi,

Alzarei

2024

Cureus

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Chronic rhinosinusitis (CRS) is marked by inflammation of the paranasal sinuses and mucosal lining of the nose. CRS can be classified as CRS with nasal polyps or CRS without polyps. In recent years, there has been increased attention on the immunological role of vitamin D in treating CRS, coupled with the observation of vitamin D deficiency among CRS patients. Vitamin D is acknowledged for its immunomodulatory properties, especially in allergic conditions. Recent studies suggest that individuals with CRS, especially those with CRS with nasal polyps, frequently demonstrate lower than normal levels of vitamin D. We conducted searches across various databases, including PubMed, Web of Science, ScienceDirect, and the Cochrane Library, both electronically and manually, to identify pertinent studies. Studies from 2003 to 2023 were included. Deficiency of vitamin D was considered with levels of vitamin D less than 30 ng/mL, and only original studies were included. Studies including patients taking vitamin D supplementation previously and patients with chronic kidney and liver diseases were excluded. We included nine studies that recruited 1,042 patients in total. More than half of the studies reported the presence of nasal polyps in CRS, and participants from four studies had CRS without nasal polyps. All of the included studies reported a negative correlation between levels of vitamin D and CRS. The majority of the studies depicted quite low levels of vitamin D among CRS patients. The degree of CRS severity as measured by endoscopic and radiological scores is moderately inversely correlated with vitamin D intake. Therefore, it is recommended that the relationship between various serum vitamin D concentrations and the severity of CRS be investigated in detail, along with an understanding of the cellular effects of vitamin D levels on the nasal mucosa.

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“…Moreover, 1,25-dihydroxy vitamin D3 was shown to significantly inhibit the ongoing proliferation of activated B cells and the generation of plasma cells [13]. In CRSwNP patients, the level of vitamin D in peripheral blood was lower than that in healthy controls and negatively correlated with disease severity [14][15][16]. The secretion of some inflammatory mediators, such as eotaxin and matrix metalloprotease (MMP), could be decreased by vitamin D [17,18].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells

Wang

Zhao

Yao

et al. 2022

Int Arch Allergy Immunol

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Background: Glucocorticoid (GC) resistance results in unsatisfactory outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) patients. Previous studies have shown that calcitriol, the active form of vitamin D, alone or in combination with corticosteroids, exerts crucial immunomodulatory effects on inflammatory responses. However, whether vitamin D can improve the effect of GCs to attenuate inflammation in the epithelium of CRSwNP remains unclear. Methods: A human bronchial epithelial cell line (Beas-2B) and primary human nasal epithelial cells (HNECs) obtained from 10 patients with CRSwNP were exposed to lipopolysaccharide (LPS) for 24 h to establish an inflammation model. LPS-stimulated HNECs and Beas-2B cells were treated with/without dexamethasone in the presence or absence of calcitriol pretreatment for 24 h. The expression levels of interleukin-6 (IL-6) mRNA and protein were determined by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Toll-like receptor 4 (TLR4)/NF-κB pathway related markers were examined by western blotting. One-way ANOVA or the Kruskal-Wallis test with post hoc analysis were used for multiple comparisons among groups. Results: The production of IL-6 in Beas-2B cells and primary HNECs after LPS stimulation was significantly increased, which could be inhibited by dexamethasone or calcitriol alone. However, significant inhibition of IL-6 production was observed in the calcitriol plus dexamethasone group. Further analysis showed that calcitriol could enhance the effect of dexamethasone in inhibiting LPS-induced overexpression of TLR4, Myd88, and phosphorylation of p65. Conclusion: Our findings demonstrated that vitamin D could improve the effect of GCs to alleviate the level of IL-6 induced by LPS via the TLR4/NF-κB pathway in human respiratory epithelial cells.

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Chronic rhinosinusitis with polyposis and serum vitamin D levels

Cited by 10 publications

References 32 publications

Association Between Serum Vitamin D Level and Ménière’s Disease

Association Between Serum Vitamin D Level and Ménière’s Disease

The Correlation Between Vitamin D Deficiency and Chronic Rhinosinusitis: A Systematic Review

Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells

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