Chronic Salmonella Osteomyelitis in a Healthy, Immunocompetent Man

Abstract

Case: A 26-year-old healthcare professional presented with knee pain and was found to have Salmonella osteomyelitis of the distal femur. Two operations, including antibiotic bead placement followed by a 6-week course of oral ciprofloxacin, were successful in eradicating the infection. Conclusion: Salmonella osteomyelitis is a well-known complication of hemoglobinopathies but is unusual in healthy individuals. This case required molecular testing and multiple cultures to obtain a diagnosis. Treatment may require debridement and antibiotics.

Vertebral discitis caused by Salmonella enterica serovar Montevideo infection

“…S. enterica serovars typically cause self-limited gastroenteritis but, can be invasive causing bacteremia and extraintestinal infection rarely appearing as an infectious osteomyelitis or discitis [3] , [4] , [5] , [10] , [11] . Salmonella osteomyelitis is reported in only 0.45% of all osteomyelitis cases and comprises 0.8% of all Salmonella infections [1] , [2] , [3] , [11] . This manifestation predominantly appears in children with hemoglobinopathies and adults with immunosuppressive disorders [10] , [11] .…”

“…Salmonella osteomyelitis is reported in only 0.45% of all osteomyelitis cases and comprises 0.8% of all Salmonella infections [1] , [2] , [3] , [11] . This manifestation predominantly appears in children with hemoglobinopathies and adults with immunosuppressive disorders [10] , [11] . There have also been a few reported cases of Salmonella species causing osteomyelitis in immunocompetent hosts without significant risk factors.…”