Chronic Sclerosing Osteomyelitis (Garr??)

Collert, S; Isacson, Johan

doi:10.1097/00003086-198204000-00022

Cited by 60 publications

(27 citation statements)

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“…Intermittent courses of antibiotics may bring short-term resolution of symptoms in some patients 17 20. IM reaming of long bones has been the most successful treatment with the largest case series of 8,14 showing good long-term survival outcomes regardless of previous failed treatments 17. It is however, associated with an increased risk of pulmonary embolism 20.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical options include debridement of the bone with exposure of the medulla, resection of the area of chronic osteomyelitis, excision with bone grafting and wire fixation 5 11–13. However, following any treatment the patients may again become symptomatic after a number of years or be found to have other lesions, for example osteoid osteomas or other bone tumours 2 14…”

Section: Introductionmentioning

confidence: 99%

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Sclerosing osteomyelitis of Garré: management of femoral pain by intramedullary nailing

et al. 2014

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We describe a case of chronic sclerosing osteomyelitis of Garré in a 50-year-old woman occurring in her right femur and presenting with uncontrolled pain. The patient was initially treated with intramedullary reaming of the femur, but 3 years later re-presented with similar symptoms. This required further reaming and intramedullary nailing, achieving good clinical outcomes and lasting pain relief at 8-year follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sclerosing osteomyelitis of Garré: management of femoral pain by intramedullary nailing

et al. 2014

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“…Such an entity was continuing to be underscored as recent as 1982-2001 [3][4][5][6]. In contemporary times, however, and with the support of hindsight, it is likely that the historical primary chronic sclerosing osteomyelitis was simply a unifocal variant of CMO, although Collert and Isacson described patients with multifocal involvement [3].…”

Section: Historical Aspectsmentioning

confidence: 99%

Chronic multifocal osteomyelitis: Is infectious causation a moot point?

Cimolai

2011

Journal of Infection and Public Health

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Chronic multifocal osteomyelitis (CMO) is an uncommon disease entity with descriptions possibly emanating from the medical literature over one century ago, and there are numerous disease entities which have been historically detailed and which are probably synonymous. The illness is one of chronicity with exacerbating and remitting focal bony lesions. The differential diagnosis for a bony lesion which ultimately proves to be CMO is initially quite broad. There is no absolute pathognomonic clinical finding, and the diagnosis is highly dependent on clinical course, histopathology, and an absence of microbial infection. Recent studies have focused on immune dysfunction or dysregulation, and there are now many other diseases which are inflammatory in nature and which have been diagnosed among patients with CMO. Despite the aforementioned, the potential for direct infectious causation or indirect causation by infectious stimulation of immunity cannot be entirely excluded. Infection as a mechanism for pathogenesis must continue to be entertained. Multi-centre studies are key to future research.

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“…Sie wird jetzt auch im deutschsprachigen Raum häufiger gefunden, in der Pädiatrie [20,21,23,27,65,67,73], in der Rheumatologie [51,52,57,61] und in der Radiologie [13,43,62]. Noch nicht ausreichend informativ ist die orthopädische und die pathologisch-anatomische Literatur über die CRMO, deren Einzeldarstellungen in ihrer Deutung international noch auseinanderdriften [1, 10,12,20,22,25,39,68,71,72,74,79].…”

Section: Rückblickunclassified

Die chronische rekurrierende multifokale Osteomyelitis

Schilling

Eckardt²,

Kessler³

2000

Z Orthop Ihre Grenzgeb

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The aim of this paper is to give a detailed description of the so-called "chronic recurrent multifocal osteomyelitis" (CRMO). The clinical, radiological and histopathological results of an analysis of 29 cases (15 children/adolescents and 14 adults) are presented and correlated to current data from the literature. We could delinate the following points: 1. CRMO is a systemic aseptic inflammation of the bone marrow (Osteitis), it can occur polytopically and association with pustulous dermatologic symptoms is possible. 2. It is not a rare disease 3. Osteomyelitis is probably "reactive" and a plasma-cell sclerotic process with ist own characteristic histologic three-phase course. 4. We could observe 5 specific types of localization which can be documented by X-ray or bone scan. 5. Accompanying arthritis os often present, especially "sympathetic coxitis". 6. The use of drugs in treatment of CRMO (i.e. azithromycin, calcitonin, and bisphosphonates) is discussed. In conclusion we want to point out, that 1. 99mTC bone scan should always be performed when there is suspicion for CRMO to reveal the pattern of affection, 2. the rheumatologist and dermatologist should be contacted, 3. operation is normally not necessary for treatment of the mostly self-limitin disease, and 4. the term "SAPHO syndrome" should be avoided, further differentiation of the diagnosis is necessary.

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Chronic Sclerosing Osteomyelitis (Garr??)

Cited by 60 publications

References 0 publications

Sclerosing osteomyelitis of Garré: management of femoral pain by intramedullary nailing

Sclerosing osteomyelitis of Garré: management of femoral pain by intramedullary nailing

Chronic multifocal osteomyelitis: Is infectious causation a moot point?

Die chronische rekurrierende multifokale Osteomyelitis

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