Chronic sclerosing panencephalitis

Haltia, Matti; Sourander, Patrick; Svennerholm, Lars

doi:10.1007/bf00685784

Cited by 7 publications

References 16 publications

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On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis

Jakumeit-Morgott

Woelk

1975

J. Neurol.

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The effect of phospholipase A1 of human brain on 1,2-diacyl-sn-glycero-3-phosphorylcholine, -ethanolamine and -serine, specifically labelled with different fatty acids at either the 1 or 2 position, was determined in subacute sclerosing panencephalitis. An increase of approximately 40% in the specific activity of phospholipase A1 could be observed for all substrates investigated during the demyelinating disorder. On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine.

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On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis

Jakumeit-Morgott

Woelk

1975

J. Neurol.

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Centrale pontine Myelinolyse

Okeda

1974

Acta Neuropathol

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Indication of peripheral nerve hyperexcitability in adult-onset subacute sclerosing panencephalitis (SSPE)

Schreurs¹,

Stålberg

Punga

2008

Neurol Sci

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Subacute sclerosing panencephalitis (SSPE) is a rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection of immune-resistant measles virus. Diagnostic hallmarks include widespread cortical dysfunction on EEG, myoclonus, white matter abnormalities on neuroradiological examination and the presence of IgG anti-measles antibodies in the cerebrospinal fluid. We present the first case of SSPE with signs of peripheral nerve hyperexcitability, observed as extra discharges following the compound motor action potential at motor nerve stimulation. In addition we demonstrate the importance of SSPE in the differential diagnosis of adult patients with psychiatric and neurological symptoms.

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Chronic sclerosing panencephalitis

Cited by 7 publications

References 16 publications

On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis

On the effect of brain phospholipase A1 on specifically labelled glycerophospholipids in the course of subacute sclerosing panencephalitis

Centrale pontine Myelinolyse

Indication of peripheral nerve hyperexcitability in adult-onset subacute sclerosing panencephalitis (SSPE)

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