Chronic Sinopulmonary Inflammatory Diseases in Adults with Undetectable Serum IgE in Inner-City Chicago: A Preliminary Observation

Famuyiwa, Funlola; Rubinstein, Israel

doi:10.1007/s00408-012-9375-y

Cited by 7 publications

(8 citation statements)

References 24 publications

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“…We found that bronchiectasis was present in 30.7% of our SIgED patients, which is a percentage similar to that reported in CVID, which is an observation that suggests that the lack of IgE has a significant negative impact on the immune defense mechanisms of the lung. In contrast to our findings, bronchiectasis is not even mentioned in the few studies reporting the clinical manifestations present in SIgED patients, which is most probably due to the lack of CT scan evaluation in patients with frequent respiratory infections [ 23 , 24 , 25 , 26 ].…”

Section: Discussioncontrasting

confidence: 99%

“…studies have reported that an SIgED may be the biomarker of an immunodeficiency with a significant clinical impact that has been overlooked until now [23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

“…The possibility of an immunodeficiency associated only with an SIgED is not considered in the classification. However, a few studies have reported that an SIgED may be the biomarker of an immunodeficiency with a significant clinical impact that has been overlooked until now [ 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, most of the patients included in these studies were selected from allergy units [ 23 , 26 ] or were patients having any allergy-related symptoms and/or requesting antiallergy medications [ 25 ], which is a bias that could have limited the spectrum of diseases found associated with SIgED. Despite these limitations, it is worth noting that these studies show that individuals with a low level of IgE, with normal values for the other immunoglobulins, present recurrent respiratory infections, suffer from autoimmune diseases, and upper and lower airway diseases [ 23 , 24 , 25 , 26 ], similar to those described in patients with CVID [ 6 , 7 , 8 ], IgGSD [ 9 ] or with SIgGD [ 8 ], SIgAD [ 11 , 12 ], and SIgM D [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency

Picado

Landazuri

Vlagea

et al. 2021

JCM

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Background: Selective IgE deficiency (SIgED) has been previously evaluated in selected patients from allergy units. This study investigates the effects of SIgED on the entire population in a hospital setting and sought to delineate in detail the clinical aspects of SIgED. Methods: A retrospective study of the data obtained from electronic medical records of 52 adult patients (56% female) with a mean age of 43 years and IgE levels of <2.0 kU/L with normal immunoglobulin (Ig) IgG, IgA, and IgM levels, seen at our hospital, without selection bias, from 2010 to 2019. Results: Recurrent upper respiratory infections were recorded in 18 (34.6%) patients, pneumonia was recorded in 16 (30.7%) patients, bronchiectasis was recorded in 16 (30.7%) patients, and asthma was recorded in 10 (19.2%) patients. Eighteen patients (34.6%) suffered autoimmune clinical manifestations either isolated (19%) or combining two or more diseases (15%), Hashimoto’s thyroiditis being the most frequent (19%), which was followed by arthritis (10%) and thrombocytopenia and/or neutropenia (5.7%). Other less frequent associations were Graves’ disease, primary sclerosing cholangitis, Sjögren’s syndrome, and autoimmune hepatitis. Eczematous dermatitis (15.3%), chronic spontaneous urticaria (17.3%), and symptoms of enteropathy (21%) were also highly prevalent. Thirty percent of patients developed malignancies, with non-Hodgkin lymphomas (13.4%) being the most prevalent. Conclusions: The clinical manifestations of SIgED encompass a variety of infectious, non-infectious complications, and malignancy. Since it cannot be ruled out that some type of selection bias occurred in the routine assessment of IgE serum Ievels, prospective studies are required to better characterize SIgED and to determine whether it should be added to the list of antibody deficiencies.

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Section: Discussioncontrasting

confidence: 99%

“…studies have reported that an SIgED may be the biomarker of an immunodeficiency with a significant clinical impact that has been overlooked until now [23][24][25][26].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency

Picado

Landazuri

Vlagea

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…First, immunoglobulin deficiencies other than IgAGMD might not have been addressed or were excluded (ie, IgG1-3D, IgE deficiency, and SAD). 44,45 Second, IgM deficiency was not reported in 3 studies, as mentioned above. [26][27][28] Because we assumed for this meta-analysis that there was no IgM deficiency in these 3 studies, which only described drug-resistant CRS, the prevalence of IgAGMD could have been underestimated in the metaanalysis, particularly in the drug-resistant CRS subgroup but not in the difficult-to-treat CRS subgroup.…”

Section: Meta-analysismentioning

confidence: 99%

Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of the literature and meta-analysis

Schwitzguébel¹,

Jandus²,

Lacroix

et al. 2015

Journal of Allergy and Clinical Immunology

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Immunoglobulin deficiency is a frequent condition in patients with CRS. An even higher prevalence of atopy was observed in patients with recurrent CRS. Therefore immunoglobulin titers and accurate allergy diagnostic workups are strongly recommended in these patients to provide specific treatments for symptom alleviation. However, there is a need for larger prospective studies addressing the effect of specific therapeutic interventions for CRS.

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Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis

et al. 2014

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Numerous studies have investigated association of interleukin-13 (IL-13) G+2044A polymorphism with COPD susceptibility; however, the results were inconsistent and inconclusive. To evaluate the association between the IL-13 G+2044A polymorphism and susceptibility to COPD, a meta-analysis of published case-control studies was performed. Based on PubMed and Chinese database, this research selected studies that examined the association of the IL-13 G+2044A polymorphism with COPD. A genetic model-free approach was used to assess whether the combined data showed this association. Then a subgroup analysis was also performed, with stratifications for race, study design, and sample size. Six studies (total 1,213 COPD patients and 801 control subjects) for the IL-13 G+2044A polymorphism with COPD were included in the meta-analysis (G- vs A-allele: OR 1.12, 95 % CI 0.96-1.32, P = 0.15; genotypes GG+GA vs genotype AA: OR 0.99, 95 % CI 0.49-2.00, P = 0.98; genotype GG vs genotypes GA+AA: OR 1.18, 95 % CI 0.97-1.44, P = 0.09; genotype GA vs genotypes GG+AA: OR 0.85, 95 % CI 0.70-1.04, P = 0.11). This meta-analysis demonstrates that the IL-13 G+2044A polymorphism does not confer susceptibility to COPD. More detailed data about individual and environment, larger sample sizes with unbiased genotyping methods and matched controls in different populations are required.

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Chronic Sinopulmonary Inflammatory Diseases in Adults with Undetectable Serum IgE in Inner-City Chicago: A Preliminary Observation

Abstract: Chronic rhinosinusitis and asthma are present in adult patients with undetectable serum total IgE who reside in inner-city Chicago. Whether this represents a biomarker of distinct chronic rhinosinusitis and asthma phenotypes in this population remains to be determined.

Cited by 7 publications

References 24 publications

Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency

Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency

Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of the literature and meta-analysis

Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis

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