Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia

Newman, Leonard S.; Platts-Mills, Thomas A.E.; Phillips, C. Douglas; Hazen, Kenneth C.; Gross, C. W.

doi:10.1001/jama.271.5.363

Cited by 234 publications

(233 citation statements)

References 22 publications

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“…These results confirm previous published evidence that clinical symptom scores are not predictive of either the presence or extent of sinus disease in most cases. [6][7][8]16 This is not surprising insofar as many of the symptoms that are used to evaluate sinus disease such as headache, posterior pharyngeal drainage, purulent nasal drainage, nasal congestion, and toothache are not specific for this disease. These symptoms are more reflective of the presence of nasal disease including all of the causes of perennial rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Peters¹,

Hatley²,

Crater³

et al. 2003

Annals of Allergy, Asthma & Immunology

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Section: Discussionmentioning

confidence: 99%

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Peters¹,

Hatley²,

Crater³

et al. 2003

Annals of Allergy, Asthma & Immunology

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“…For more than 80 years, the coexistence of asthma and chronic rhinosinusitis has been noted in the medical literature (51)(52)(53). The debate still remains as to whether chronic rhinosinusitis is a precipitating factor for bronchial asthma.…”

Section: Epidemiologic Studiesmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

170

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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“…20,21 Elevated total IgE is a risk factor for the presence of severe CS 22 and both sensitivity to multiple allergens and sensitivity to perennial allergens (e.g., dust mites) are independently associated with increased likelihood of having CS. 23 Together, these studies support the concept that CS could be an atopic disease driven by IgE sensitization to aeroallergens.…”

Section: Epidemiology Of Allergy In Csmentioning

confidence: 99%

Chronic sinusitis pathophysiology: The role of allergy

Kennedy

Borish

2013

Am J Rhinol�Allergy

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Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia

Cited by 234 publications

References 22 publications

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Chronic sinusitis pathophysiology: The role of allergy

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Chronic sinusitis. Relationship of computed tomographic findings to allergy, asthma, and eosinophilia

Cited by 234 publications

References 22 publications

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Chronic sinusitis pathophysiology: The role of allergy

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Product

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper